Catalogue of the archive of Sir Edward Penley Abraham FRS, (1913-1999), biochemist

Bodleian Library, University of Oxford

Original catalogue by Simon Coleman and Peter Harper; EAD 2002 version by Lawrence Mielniczuk
2018



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Table of Contents

Introduction
A   Biographical 1925-2000, n.d.
    A.1   Autobiographical and biographical 1957-1990s
    A.2   Career, honours and awards 1925-2000
    A.3   School and undergraduate notebooks 1928-1936, n.d.
    A.4   Diaries 1963-1992
    A.5   E.P. Abraham Trusts 1979-1989
    A.6   Charities and appeals 1975-1997, n.d.
    A.7   History of Science 1976-1998, n.d.
    A.8   Archives and books 1986-2000
    A.9   Personal correspondence 1973-1998, n.d.
    A.10   Publications list n.d.
B   University of Oxford 1954-1998, n.d.
    B.1   Sir William Dunn School of Pathology 1954-1994
    B.2   Lincoln College 1960-1996, n.d.
    B.3   Other Colleges and University organisations 1969-1998, n.d.
C   Research 1935-1995, n.d.
    C.1   Early research and research on penicillin 1935-1950, n.d.
    C.2   Laboratory notebooks and papers 1946-1983, n.d.
    C.3   Medical Research Council 1949-1985, n.d.
    C.4   National Research Development Corporation (NRDC) (British Technology Group (BTG) 1952-1995, n.d.
    C.5   Other organisations 1946-1994, n.d.
    C.6   Scientific correspondence 1955-1983
    C.7   Bacilysin research 1957-1991
    C.8   Legal cases 1978-1989
    C.9   Cephalosporin C history 1948-1995, n.d.
    C.10   Miscellaneous papers 1945-1991, n.d.
D   Publications 1939-1996, n.d.
    D.1   Drafts 1939-1996, n.d.
    D.2   Editorial correspondence 1949-1988
E   Lectures and broadcasts 1942-1993, n.d.
    E.1   Lectures associated with teaching 1942-1973, n.d.
    E.2   Public lectures and broadcasts 1960-1993, n.d.
F   Visits and conferences 1955-1995
G   Societies and organisations 1957-1998
H   Correspondence 1944-1998, n.d.
    H.1   Scientific correspondence 1944-1998
    H.2   Scientific correspondence 1946-1995
    H.3   Shorter scientific correspondence 1944-1998, n.d.
    H.4   References and recommendations 1958-1996
I   Non-text material 1930-1995, n.d.
    I.1   Photographs 1930-1995, n.d.
    I.2   Slides and videos 1978-1990, n.d.


Archive of Sir Edward Penley Abraham

1925-2000

Abstract:
Correspondence and papers of Sir Edward Penley Abraham FRS, (1913-1999), biochemist.

Extent: 28.65 linear metres, 191 physical shelfmarks
Language(s) of Material: English

Full range of shelfmarks:

MSS. Abraham 1-191 (Former reference: NCUACS 103/2/02/A.1 - NCUACS 103/2/02/J.43)

Biographical History

Edward Penley Abraham was born at Southampton on 10 June 1913 and educated at the King Edward VI School. He won an exhibition to Queen's College Oxford, taking a First in chemistry and acquiring a particular interest in organic chemistry. At the Dyson Perrins Laboratory in Oxford he undertook research on peptides and studied for a D.Phil. under Robert Robinson. His work included an important contribution to the study of lysozyme which was also being investigated by Howard Florey and Ernst Chain at the Sir William Dunn School of Pathology. After taking his doctorate in 1938, Abraham was able to develop his increasing interest in biochemistry at the Biokemiska Institut, Stockholm, which he attended as a Rockefeller Travelling Fellow. He returned to England the following year and in January 1940 took up a post at the Sir William Dunn School of Pathology at Florey's invitation.

During their investigations of naturally occurring antibiotic substances, Florey and Chain had turned their attention to penicillin in 1938. After experiments on mice in the summer of 1940 yielded encouraging results, Abraham joined the work on the purification and chemistry of penicillin. In the course of this research he and Chain observed that the antibiotic was destroyed by an enzyme produced in a strain of E-coli. The discovery of this enzyme, named penicillinase, proved to be of great importance to future studies of micro-organisms and antibiotic resistance. Following the first successful clinical trial of penicillin on humans in February 1941, Abraham played a significant role in the elucidation of its chemical structure and in 1943, with Chain, proposed the novel B-lactam structure with a fused two ring system. This theory was strongly opposed by Abraham's former supervisor, Robinson, who favoured an alternative structure. The issue was settled in 1945 when X-ray crystallographic study by Dorothy Hodgkin and Barbara Low confirmed the B-lactam structure.

Although the astonishing clinical impact of penicillin would overshadow all subsequent breakthroughs in antibiotics, the discovery of Cephalosporin C by Abraham and Guy Newton led to the appearance of a new group of B-lactam antibiotics of equal importance to medicine and of greater commercial value. A culture of the cephalosporium fungus, whose antibiotic properties were first discovered in Sardinia by Giuseppe Brötzu in 1945, reached the Sir William Dunn School of Pathology in September 1948. After initial experiments by N.G. Heatley, the production of culture fluids was turned over to the Medical Research Council's Antibiotics Research Station at Clevedon in July 1949. Abraham and his colleagues succeeded in isolating a number of antibiotic substances from the culture fluids, the one producing the results originally observed by Brötzu given the name 'Cephalosporin N'. The discovery of Cephalosporin C, a substance detected in minute quantities in partially purified Cephalosporin N in September 1953, was epoch making. It was active against certain bacteria unaffected by penicillin, while being resistant to penicillinase and of very low toxicity. Cephalosporin N was shown to be a new form of penicillin and was re-named 'Penicillin N'.

Despite the combined efforts of Oxford, Clevedon, and the Glaxo Group there proved to be many difficulties with the production of Cephalosporin C by fermentation and it took until 1959 for Abraham and Newton to determine its chemical structure. Later that year they showed that subtle mutations of the Cephalosporin C molecule could lead to the production of more potent antibiotics which would still be resistant to penicillinase. Work aimed at producing higher yields of the nucleus of the molecule (7-aminocephalosporanic acid or 7-ACA) continued during the early 1960s, with Glaxo and other pharmaceutical laboratories licensed by the National Research Development Corporation (NRDC) collaborating with the Dunn School. The successful outcome of this painstaking work enabled studies of semi-synthetic cephalosporins to proceed, with the drugs cephalothin and cephaloridine being introduced into medicine in 1964. The NRDC's worldwide patenting and licensing scheme covering the cephalosporins eventually yielded huge royalties, for many years the chief source of income for the corporation. Abraham diverted the greater part of his royalty income into two trusts, the E.P. Abraham Research Fund and the E.P.A. Cephalosporin Fund, which he set up to support medical, biological and chemical research, especially at Oxford.

After 1964 Abraham continued to conduct research on B-lactam antibiotics, including the biosynthesis and enzyme inactivation of penicillins and cepahlosporins, while also investigating other antibiotics such as bacilysin. He maintained a strong interest in antibiotics research abroad, and travelled extensively to visit research laboratories and give lectures such as the Rennebohm Lecture at the University of Wisconsin (1966-1967) and the Squibb Lecture at Rutgers University (1972).

Abraham was elected a Fellow of the Royal Society in 1958 and became Professor of Chemical Pathology in 1964. In addition to his knighthood in 1980, his outstanding contributions in the antibiotics field brought him numerous awards, including the Royal Medal of the Royal Society (1973), a CBE (1973), the Mullard Prize of the Royal Society (1980), and several honorary degrees. Abraham also contributed to academic life in Oxford as a Fellow of Lincoln College from 1948 to 1980 (an Honorary Fellow from 1980) and as an Honorary Fellow of a number of other colleges.

A man of exceptional modesty, Abraham was affectionately regarded by his colleagues at all levels. He remained on good terms with both Florey and Chain after their acrimonious breach and later wrote well-received articles on both scientists for Biographical Memoirs of Fellows of the Royal Society.

He married Absbjörg Harung, a Norwegian, in 1939 and they had a son. Abraham died on 8 May 1999.

Scope and Content

The material is presented in the order given above.

Section A, Biographical, includes a variety of material reflecting many aspects of Abraham's personal and professional life. A number of his school notebooks survive, along with eighteen undergraduate notebooks. There are letters of congratulation on his election to the Fellowship of the Royal Society, 1958, and on his receipt of the Royal Medal of the Royal Society in 1973, and correspondence and papers relating to other honours and awards. Included also are correspondence concerning the history of antibiotics (mostly 1990s), correspondence and papers relating to his support of various charities and appeals later in his life, appointments diaries (1963-1992), and a sequence of personal correspondence, 1974-1998.

Section B, University of Oxford, is short. The material includes correspondence and papers relating to the business of Lincoln College (1960-1996), of which Abraham was a Fellow, and building work and administration at the Sir William Dunn School of Pathology (1954-1994). Other papers, chiefly concerning social and fundraising events, reflect his associations with other Oxford colleges and organisations, sometimes through donations by the Abraham Trusts.

Section C, Research, presents extensive and diverse material spanning some sixty years of Abraham's biochemical research. There are notebooks, correspondence, publications and other papers, chiefly relating to research on cephalosporins and related substances by Abraham's team and other organisations. There are a few of his notebooks dating from his period at the Dyson Perrins Laboratory and his early years at the Sir William Dunn School of Pathology; one survives from his year in Stockholm (1938/1939) as a Rockefeller Travelling Fellow. The early Dunn School notebooks include details of experiments on penicillin from 1940. There is significant coverage of the collaborative research with the Antibiotics Research Station of the Medical Research Council on the cephalosporium culture fluids in the 1950s, the work that led to the isolation of Cephalosporin C and the determination of its chemical structure. A large body of correspondence and papers relates to the involvement, through to the 1990s, of the National Research Development Corporation in the on-going research on the cephalosporin antibiotics and their commercial exploitation, the participation of licensed pharmaceutical companies such as Squibb, and legal cases concerning cephalosporin patents in which Abraham provided expert opinion. Experimental work by Abraham's team on a range antibiotics and related compounds, including Cephalosporin C, Bacilysin and B-lactamases, is documented by a large group of laboratory notebooks dating from 1946 to 1983. They are mostly the work of Abraham's research assistants, though a few are in his hand. A small body of correspondence and papers relates to research on bacilysin from 1957, and there is also some scientific correspondence of a more general nature.

Section D, Publications, comprises Abraham's drafts of scientific papers, book reviews and other articles, dating from 1956 to 1998, and editorial correspondence. Of particular interest are the drafts and correspondence relating to his Biographical Memoirs of Fellows of the Royal Society articles for Howard Florey (1971) and Ernst Chain (1983). The correspondence highlights the sensitive issues Abraham had to negotiate in the preparation and drafting of the Memoirs. There are also drafts of other obituaries he wrote for Florey and Chain.

Section E, Lectures and broadcasts, principally comprises drafts and correspondence relating to public lectures given by Abraham from c.1960 to 1993. Most lectures are on the origin and development of B-lactam antibiotics; one given at the National Portrait Gallery in 1993 surveys the discoveries of Sir Alexander Fleming. A small amount of lecture material used by Abraham for teaching is included. The papers relating to broadcasts is slight, chiefly concerning Abraham's contributions to various television and radio programmes on penicillin, the cephalosporins and the work of Howard Florey, dating from 1962 to 1991.

Section F, Visits and conferences, covers the period 1955 to 1995. The material chiefly covers Abraham's participation in symposia and conferences on chemotherapy, antibiotics, and, in some cases, specifically B-lactam antibiotics. On longer stays abroad he sometimes combined attendance at symposia with lectures at universities and visits to pharmaceutical laboratories. Among the visits and conferences for which significant documentation survives are the International Congresses of Chemotherapy held in Vienna, 1967 and 1983; the Interscience Conferences on Antimicrobial Agents and Chemotherapy held in Chicago, 1967 and 1981; and a visit to India in January 1985, which included the Asian Congress of Pharmacology in New Delhi. Included are drafts of papers given by Abraham at symposia.

Section G, Societies and organisations, presents material covering Abraham's involvement in many British scientific organisations, including the Biochemical Society, the Chemical Society, the Society for General Microbiology, and the Royal Society. Overseas organisations are represented by the American Academy for Arts and Sciences and the Australian National University (John Curtin School of Medical Research). Much of the correspondence in this section is general in nature, though there is material relating to lectures and addresses given by Abraham, such as the 5th L.P. Garrod Lecture for the British Society for Antimicrobial Chemotherapy in 1986.

Section H, Correspondence, principally consists of scientific correspondence, 1944-1998, arranged by individual or country. The correspondents include some colleagues of Abraham, such as Norman Heatley, Henry Harris, and Guy Newton, research assistants and workers in Abraham's laboratory, and scientists in other institutions. The correspondence arranged by country reflects Abraham's strong interest in antibiotics research overseas, and documents visits to many countries for participation in conferences and meetings. There is also a short sequence of material concerning references and recommendations.

Section J, Non-text material, largely consists of photographs of Abraham, with a few of colleagues such as Guy Newton, dating from 1930-1995. Included are school photographs, portraits from Abraham's early career, and several showing him with colleagues and fellow scientists taken at conferences or functions. There are also a few lecture slides and videotapes, one recording an event at the Sir William Dunn School of Pathology, at which Abraham spoke, celebrating the 50th anniversary of the published paper on the therapeutic application of penicillin.

Arrangement

Section A: Biographical (MSS. Abraham 1-7)

Section B: University of Oxford (MSS. Abraham 8-13)

Section C: Research (MSS. Abraham 14-116)

Section D: Publications (MSS. Abraham 117-133)

Section E: Lectures and broadcasts (MSS. Abraham 134-138)

Section F: Visits and conferences (MSS. Abraham 139-145)

Section G: Societies and organisations (MSS. Abraham 146-152)

Section H: Correspondence (MSS. Abraham 153-188)

Section J: Non-text material (MSS. Abraham 189-191)

Restrictions on Access

Some material is closed.

Acquisition

The papers were received from the Sir William Dunn School of Pathology, University of Oxford, with additional biographical material from Mrs. T. Mayes, Sir Edward Abraham's niece, in the summer of 2000.

Preferred Form of Citation

Oxford, Bodleian Library [followed by shelfmark and folio or page reference, e.g. MS. Abraham 1, folder A.7].

Subject(s)

Biochemistry
Antibiotics

A   Biographical 1925-2000, n.d.

A.1   Autobiographical and biographical 1957-1990s

Full range of shelfmarks:

MS. Abraham 1/A.1 - MS. Abraham 1/A.10

Personal records
Date: 1957
Shelfmark: MS. Abraham 1/A.1
Language(s) of Material: English
Extent: 1 folder

Scope and Content

'Personal records' prepared for the Royal Society. (Abraham was elected to the Fellowship of the Royal Society in 1958.)

Autobiographical account
Date: 1980
Shelfmark: MS. Abraham 1/A.2
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Autobiographical account for McGraw-Hill Modern Scientists and Engineer.

NRDC publication
Date: 1980 (or later)
Shelfmark: MS. Abraham 1/A.3
Language(s) of Material: English
Extent: 1 folder

Scope and Content

'Sir Edward Abraham and the cephalosporin and penicillin stories', an NRDC [National Research Development Corporation] publication' The article was written by J.C. Cain, Managing Director, NRDC.

Biography and Portrait
Date: 1980s
Shelfmark: MS. Abraham 1/A.4
Language(s) of Material: English
Extent: 1 folder

Scope and Content

'Biography' for Central Office of Information, 1981.

'New antibiotic from another happy accident', a portrait of Abraham, Oxford Times, 13 December 1985.

Article about Abraham
Date: 1990
Shelfmark: MS. Abraham 1/A.5
Language(s) of Material: English
Extent: 1 folder

Scope and Content

'Edward Abraham: A major figure in antibiotics', The Biochemist.

Biographical details
Date: 1990s
Shelfmark: MS. Abraham 1/A.6
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Description of Abraham's career at Oxford for the University's External Relations Office, 1991.

Brief biographical details for meeting of Oxford University's Chancellor's Court of Benefactors, 1998.

A tribute to Abraham
Date: 5 December 1991
Shelfmark: MS. Abraham 1/A.7
Language(s) of Material: English
Extent: 1 folder

Scope and Content

'Chance favours the prepared mind. A tribute to the work of Sir Edward Abraham and his distinguished colleagues at the Sir William Dunn School of Pathology'.

Tribute to Abraham
Date: 1993
Shelfmark: MS. Abraham 1/A.8
Language(s) of Material: English
Extent: 1 folder

Scope and Content

'Sir Edward Abraham: An Eightieth Birthday Tribute', Lincoln College Record.

Entries for biographical directories
Date: 1971-1997
Shelfmark: MS. Abraham 1/A.9-A.10
Language(s) of Material: English
Extent: 2 folders

A.2   Career, honours and awards 1925-2000

Full range of shelfmarks:

MS. Abraham Abraham 1/A.11 - MS. Abraham 2/A.40

King Edward VI School, Southampton
Date: 1925-1926
Shelfmark: MS. Abraham 1/A.11
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Swimming certificates. (Abraham attended the school, 1925-1932. He was subsequently a major benefactor.)

Oxford & Cambridge Schools Examination Board Certificate
Date: 1929
Shelfmark: MS. Abraham 1/A.12
Language(s) of Material: English
Extent: 1 folder

Correspondence
Date: 1991-1998
Shelfmark: MS. Abraham 1/A.13-A.16
Language(s) of Material: English
Extent: 4 folders

Scope and Content

Correspondence with Chairman of Governors, Headmaster and others.

The Queen's College, Oxford
Date: 1931-1934
Shelfmark: MS. Abraham 1/A.17
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence and papers, including a letter of 20 November 1931 from the College informing Abraham of his election to an Exhibition.

Rockefeller Travelling Fellowship, University of Stockholm
Date: 1939
Shelfmark: MS. Abraham 1/A.18
Language(s) of Material: English
Extent: 1 folder

Scope and Content

One letter only from the head of the institute, H. von Euler.

Nuffield (Penicillin) Research Fellowship, Lincoln College, Oxford
Date: 1948
Shelfmark: MS. Abraham 1/A.19
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Typescript note from the Rector on the terms of the Fellowship.

Election to the Fellowship of the Royal Society
Date: 1958
Shelfmark: MS. Abraham 1/A.20-A.22
Language(s) of Material: English
Extent: 3 folders

Scope and Content

Letters of congratulations, in alphabetical order:

Certificates
Date: 1966-1967
Shelfmark: MS. Abraham 1/A.23
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Rennebohm Lecturer of the University of Wisconsin School of Pharmacy, 1966-1967.

Honorary membership American Pharmaceutical Association Academy of Pharmaceutical Sciences, 1967.

Appointed Commander of the Order of the British Empire (C.B.E.)
Date: 1972-1973
Shelfmark: MS. Abraham 1/A.24
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Official notification and letters of congratulations, A-H.

Appointed Commander of the Order of the British Empire (C.B.E.)
Date: 1972-1973
Shelfmark: MS. Abraham 1/A.25
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Official notification and letters of congratulations, J-Z and unidentified, first names only.

Honorary Fellowship, Queen's College, Oxford
Date: 1973
Shelfmark: MS. Abraham 1/A.26
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Letters from the Provost and others regarding election to the Honorary Fellowship.

Award of Royal Medal of the Royal Society
Date: 1973-1974
Shelfmark: MS. Abraham 1/A.27
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence with the Royal Society.

Award of Royal Medal of the Royal Society
Date: 1973
Shelfmark: MS. Abraham 1/A.28
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Letters of congratulation, A-M.

Award of Royal Medal of the Royal Society
Date: 1973
Shelfmark: MS. Abraham 1/A.29
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Letters of congratulation, N-W and unidentified, first names only

Knighthood
Date: 1980
Shelfmark: MS. Abraham 2/A.30
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Newspaper-cutting only.

Honorary degree, University of Exeter
Date: 1980
Shelfmark: MS. Abraham 2/A.31
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence regarding arrangements and manuscript notes of a speech by Abraham.

Dinner in Abraham's honour at Lincoln College, Oxford
Date: 1980
Shelfmark: MS. Abraham 2/A.32
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Photocopy of manuscript notes for Abraham's speech.

Mullard Award of the Royal Society
Date: 1980-1981
Shelfmark: MS. Abraham 2/A.33
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence with the Royal Society.

Proposed nominations of Abraham for Nobel Prize
Date: 1981, 1983, and 1997
Shelfmark: MS. Abraham 2/A.34
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence regarding proposed nominations of Abraham for Nobel Prize.

Honorary Fellowships of Oxford Colleges
Date: 1983, 1986
Shelfmark: MS. Abraham 2/A.35
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Honorary Fellowship, St Peter's College, Oxford, 1983. Letter of congratulations only.

Honorary Fellowship, Keble College, Oxford, 1986. This invitation was declined by Abraham: 'But some time ago I began to feel embarrassed by the number of my Honorary Fellowships and decided that I should not allow the list to grow if the possibility of its doing so were to arise'.

Honorary degree, Oxford University
Date: 1983-1984
Shelfmark: MS. Abraham 2/A.36
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Letters of congratulation and brief correspondence regarding arrangements.

Honorary degree, University of Strathclyde
Date: 1988-1989
Shelfmark: MS. Abraham 2/A.37
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence regarding arrangements.

Honorary degree, Harvard University
Date: 1996-1997
Shelfmark: MS. Abraham 2/A.38
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence and papers.

Opening of the Oxford University Pathology Support Building
Date: 1997
Shelfmark: MS. Abraham 2/A.39
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Abraham officially opened the building to which he had 'contributed so generously', 10 October 1997.

Funeral and memorial service
Date: 1999-2000
Shelfmark: MS. Abraham 2/A.40
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Includes memorial address by H. Harris as published in Oxford Magazine, Nougth Week, Hilary Term, 2000.

Draft of obituary by L.D. Sabbath.

A.3   School and undergraduate notebooks 1928-1936, n.d.

Full range of shelfmarks:

MS. Abraham 2/A41 - MS. Abraham 4/A.66

King Edward's School notebook
Date: 1928
Shelfmark: MS. Abraham 2/A.41
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with label 'King Edward's School, Southampton' on front cover with pupil's name 'E. Abraham', the subject 'Physics' and the date 'Oct. 1928'.

Used for experimental work. A list of experiments is on the first lined page at the front.

King Edward's School notebook
Date: n.d.
Shelfmark: MS. Abraham 2/A.42
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with label 'King Edward's School, Southampton' on front cover with pupil's name 'E. Abraham', the subject 'Physics'.

Used for experimental work.

King Edward's School notebook
Date: n.d.
Shelfmark: MS. Abraham 2/A.43
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with label 'King Edward's School, Southampton' on front cover with pupil's name 'E. Abraham' and the subject 'Physics. Heat & light sound'.

Used for experimental work.

King Edward's School notebook
Date: n.d.
Shelfmark: MS. Abraham 2/A.44
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with label 'King Edward's School, Southampton' on front cover with pupil's name 'E. Abraham' and the subject 'Physics' [the rest of the label torn but probably indicated that the particular areas of the subject covered were magnetism and electricity].

Used for experimental work

King Edward's School notebook
Date: n.d.
Shelfmark: MS. Abraham 2/A.45
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with label 'King Edward VI. School, Southampton' on front cover with pupil's name 'E.P. Abraham' and the subject 'Physics'.

Used for notes on the 'Properties of Matter'.

King Edward's School notebook
Date: n.d.
Shelfmark: MS. Abraham 2/A.46
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with label 'King Edward VI. School, Southampton' on front cover with pupil's name 'E.P. Abraham' and the subject 'Physics'.

Used for notes on the 'Properties of Matter'.

King Edward's School notebook
Date: n.d.
Shelfmark: MS. Abraham 2/A.47
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with label 'King Edward VI. School, Southampton' on front cover with pupil's name 'E.P. Abraham' and the subject 'Physics II'.

Used for notes on magnetism and electricity.

King Edward's School notebook
Date: 1930
Shelfmark: MS. Abraham 2/A.48
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with label 'King Edward VI. School, Southampton' on front cover with pupil's name 'E.P. Abraham'.

Used for essays. The first essay on pragmatism is dated at the end 'Essay Club Winter Term 1930'.

The Queen's College, Oxford, undergraduate notebook
Date: 1931?
Shelfmark: MS. Abraham 2/A.49
Language(s) of Material: English
Extent: 1 volume

Scope and Content

King Edward VI. School, Southampton, notebook with school label on front cover obscured with new blank label inscribed 'The Phase Rule'. 'E.P. Abraham' inscribed inside front cover.

Used for undergraduate notes.

The Queen's College, Oxford, undergraduate notebook
Date: 1932
Shelfmark: MS. Abraham 3/A.50
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham Queen's College Oxford' inscribed inside front cover.

Used for essays on chemistry? 'The composition of water and the relative atomic weights of oxygen and hydrogen' is dated 'Nov. 1st 1932'.

The Queen's College, Oxford, undergraduate notebook
Date: 1933
Shelfmark: MS. Abraham 3/A.51
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham Queen's College Oxford' inscribed inside front cover.

Used for chemistry notes. First page headed 'The methods for the determination of vapour density'. Latest date in the text 1933 (in note on the hydrogen isotope).

The Queen's College, Oxford, undergraduate notebook
Date: 1934
Shelfmark: MS. Abraham 3/A.52
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham The Queen's College [Oxford] 1934' inscribed inside front cover.

Used from the front for notes on 'Isomerism'.

The Queen's College, Oxford, undergraduate notebook
Date: 1934
Shelfmark: MS. Abraham 3/A.53
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham The Queen's College Oxford 1934' inscribed inside front cover.

Used from the front for notes on 'The kinetic theory of gases'.

The Queen's College, Oxford, undergraduate notebook
Date: 1934
Shelfmark: MS. Abraham 3/A.54
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham 1934' inscribed on the front cover.

Used from the front for notes on 'The lesser known elements' and from the back for notes on 'Inorganic compounds'.

The Queen's College, Oxford, undergraduate notebook
Date: 1934
Shelfmark: MS. Abraham 3/A.55
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham 1934' inscribed on the front cover.

Used from the front for notes on 'Corrosion, Passivity and the Protection of Metals'.

The Queen's College, Oxford, undergraduate notebook
Date: 1934
Shelfmark: MS. Abraham 3/A.56
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham The Queen's College [Oxford] 1934' inscribed inside front cover.

Used for notes on 'Oxidation and Reduction in Organic Chemistry' from the front and on 'Mechanism of Reactions' from the back.

The Queen's College, Oxford, undergraduate notebook
Date: 1934
Shelfmark: MS. Abraham 3/A.57
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham The Queen's College [Oxford] 1934' inscribed inside front cover.

Used from the front for notes on 'Acids and bases (continued)'.

The Queen's College, Oxford, undergraduate notebook
Date: 1935
Shelfmark: MS. Abraham 3/A.58
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham' inscribed inside front cover.

Used for notes on 'Rubber', 'Ketenes', 'The basic properties of oxygen', etc.

The Queen's College, Oxford, undergraduate notebook
Date: 1936
Shelfmark: MS. Abraham 4/A.59
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham The Queen's College [Oxford]' inscribed inside front cover.

Used from the front for notes on 'Relativity', 'The Alkaloids', 'Structure and Synthesis', and 'Carbohydrates'.

The Queen's College, Oxford, undergraduate notebook
Date: n.d.
Shelfmark: MS. Abraham 4/A.60
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'Essays E.P. Abraham The Queen's [College Oxford]' inscribed inside front cover.

There are essays on 'Fermentation', 'The Constitution of Alcohol and Ether', 'Aldehydes', 'Nitrification', 'The fixation of Nitrogen'.

The Queen's College, Oxford, undergraduate notebook
Date: n.d.
Shelfmark: MS. Abraham 4/A.61
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham The Queen's College [Oxford]' inscribed inside front cover.

First page headed 'Essays'. However, contents may be summary notes of contents of earlier notebooks perhaps prepared for revision purposes.

The Queen's College, Oxford, undergraduate notebook
Date: 1934
Shelfmark: MS. Abraham 4/A.62
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham 1934' inscribed inside front cover.

Used for notes regarding practical work. First page headed 'Quantitative Analysis'.

The Queen's College, Oxford, undergraduate notebook
Date: 1934
Shelfmark: MS. Abraham 4/A.63
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham The Queen's College Oxford 1934' inscribed inside front cover.

Used for notes regarding practical work. First page headed 'Organic Preparations etc.'

The Queen's College, Oxford, undergraduate notebook
Date: n.d.
Shelfmark: MS. Abraham 4/A.64
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham The Queen's College [Oxford]' inscribed inside front cover.

Used for notes regarding practical work. First page headed 'Points in Physical Chemistry'.

The Queen's College, Oxford, undergraduate notebook
Date: n.d.
Shelfmark: MS. Abraham 4/A.65
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham The Queen's College [Oxford]' inscribed inside front cover.

Used from both ends for notes regarding practical work. First page at front headed 'Potassium iodate'. First page at back headed 'Gas Manipulation'.

The Queen's College, Oxford, undergraduate notebook
Date: n.d.
Shelfmark: MS. Abraham 4/A.66
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with 'E.P. Abraham The Queen's College [Oxford]' inscribed inside front cover.

Used for notes regarding practical work. First page headed 'Tetrahydrocarbazole'.

A.4   Diaries 1963-1992

Full range of shelfmarks:

MS. Abraham 4/A.67 - MS. Abraham 6/A.96

Appointment Diary
Date: 1963
Shelfmark: MS. Abraham 4/A.67
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1964
Shelfmark: MS. Abraham 4/A.68
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1965
Shelfmark: MS. Abraham 4/A.69
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1966
Shelfmark: MS. Abraham 4/A.70
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1967
Shelfmark: MS. Abraham 4/A.71
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1968
Shelfmark: MS. Abraham 4/A.72
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1969
Shelfmark: MS. Abraham 4/A.73
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1971
Shelfmark: MS. Abraham 5/A.74
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1972
Shelfmark: MS. Abraham 5/A.75
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1973
Shelfmark: MS. Abraham 5/A.76
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1974
Shelfmark: MS. Abraham 5/A.77
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1975
Shelfmark: MS. Abraham 5/A.78
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1976
Shelfmark: MS. Abraham 5/A.79
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1977
Shelfmark: MS. Abraham 5/A.80
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1978
Shelfmark: MS. Abraham 5/A.81
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1978
Shelfmark: MS. Abraham 5/A.82
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1979
Shelfmark: MS. Abraham 5/A.83
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1980
Shelfmark: MS. Abraham 5/A.84
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1981
Shelfmark: MS. Abraham 5/A.85
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1982
Shelfmark: MS. Abraham 5/A.86
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1983
Shelfmark: MS. Abraham 5/A.87
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1984
Shelfmark: MS. Abraham 6/A.88
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1985
Shelfmark: MS. Abraham 6/A.89
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1986
Shelfmark: MS. Abraham 6/A.90
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1987
Shelfmark: MS. Abraham 6/A.91
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1988
Shelfmark: MS. Abraham 6/A.92
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1989
Shelfmark: MS. Abraham 6/A.93
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1990
Shelfmark: MS. Abraham 6/A.94
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1991
Shelfmark: MS. Abraham 6/A.95
Language(s) of Material: English
Extent: 1 volume

Appointment Diary
Date: 1992
Shelfmark: MS. Abraham 6/A.96
Language(s) of Material: English
Extent: 1 volume

A.5   E.P. Abraham Trusts 1979-1989

Scope and Content

Abraham established a number of charitable trusts with funds arising from the development of the cephalosporin antibiotics.

Full range of shelfmarks:

MS. Abraham 6/A.97 - MS. Abraham 6/A.98

E.P. Abraham Trusts
Date: 1979
Shelfmark: MS. Abraham 6/A.97
Language(s) of Material: English
Extent: 1 item

Scope and Content

Letter from E.P. Abraham regarding cephalosporin funds in reply to an enquiry from G. Wilkinson, February 1979.

E.P. Abraham Trusts
Date: 1989
Shelfmark: MS. Abraham 6/A.98
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Letter from Kidsons chartered accountants, 20 February 1989, enclosing photocopies of Deeds of Trust in respect of the E.P. Abraham Research Fund, 17 March 1967, the Guy Newton Research Fund, 17 March 1967, and the E.P.A. Cephalosporin Fund, 18 May 1970.

A.6   Charities and appeals 1975-1997, n.d.

Full range of shelfmarks:

MS. Abraham 6/A.99 - MS. Abraham 6/A.101

Charities and appeals
Date: 1975-1980
Shelfmark: MS. Abraham 6/A.99
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence and papers regarding charities and appeals supported by Abraham.

Charities and appeals
Date: 1990-1994
Shelfmark: MS. Abraham 6/A.100
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence and papers regarding charities and appeals supported by Abraham.

Charities and appeals
Date: 1997, n.d.
Shelfmark: MS. Abraham 6/A.101
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence and papers regarding charities and appeals supported by Abraham.

A.7   History of Science 1976-1998, n.d.

Full range of shelfmarks:

MS. Abraham 7/A.102 - MS. Abraham 7/A.103

Correspondence with historians
Date: 1976, 1994, 1996, 1997
Shelfmark: MS. Abraham 7/A.102
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence with historians and others regarding the history of antibiotics, biographies of scientists etc.

Correspondence with historians
Date: 1997, 1998, n.d.
Shelfmark: MS. Abraham 7/A.103
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence with historians and others regarding the history of antibiotics, biographies of scientists etc.

A.8   Archives and books 1986-2000

Full range of shelfmarks:

MS. Abraham 7/A.104 - MS. Abraham 7/A.105

Archives and books
Date: 1986-1989
Shelfmark: MS. Abraham 7/A.104
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence and papers regarding arrangements made for Abraham's archives and books and related matters.

Archives and books
Date: 1997-2000
Shelfmark: MS. Abraham 7/A.105
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence and papers regarding arrangements made for Abraham's archives and books and related matters. The item from 2000 is a list of the books transferred from Abraham's home to Lincoln College, Oxford.

A.9   Personal correspondence 1973-1998, n.d.

Full range of shelfmarks:

MS. Abraham 7/A.106 - MS. Abraham 7/A.109-114

Personal correspondence
Date: 1974-1976
Shelfmark: MS. Abraham 7/A.106
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Personal correspondence, including replies to Abraham's letters of congratulation.

Personal correspondence
Date: 1979-1993
Shelfmark: MS. Abraham 7/A.107
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Personal correspondence, including replies to Abraham's letters of congratulation.

Personal correspondence
Date: 1995-1998, n.d.
Shelfmark: MS. Abraham 7/A.108
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Personal correspondence, including replies to Abraham's letters of congratulation.

Personal correspondence
Date: 1973-1977, n.d.
Shelfmark: MS. Abraham 7/A.109-114
Language(s) of Material: English
Extent: 6 folders

Scope and Content

Correspondence and papers with B.L. Parry and others.

Restrictions on Access:

Closed.


A.10   Publications list n.d.

Full range of shelfmarks:

MS. Abraham 7/A.115

Publications list
Date: n.d.
Shelfmark: MS. Abraham 7/A.115
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Typescript chronological list of Abraham's publications.

B   University of Oxford 1954-1998, n.d.

B.1   Sir William Dunn School of Pathology 1954-1994

Full range of shelfmarks:

MS. Abraham 8/B.1 - MS. Abraham 10/B.37

Invoices
Date: 1954
Shelfmark: MS. Abraham 8/B.1-B.19
Language(s) of Material: English
Extent: 19 folders

Scope and Content

Invoices, etc., for equipment and supplies purchased by the William Dunn School.

School extension
Date: 1964-1975, 1980
Shelfmark: MS. Abraham 9/B.20-B.35
Language(s) of Material: English
Extent: 16 folders

Scope and Content

Correspondence and papers regarding the building of a major extension to the School.

Minutes of Departmental Committee Meetings etc.
Date: 1992-1994
Shelfmark: MS. Abraham 10/B.36
Language(s) of Material: English
Extent: 1 folder

Miscellaneous correspondence and papers
Date: 1992-1994
Shelfmark: MS. Abraham 10/B.37
Language(s) of Material: English
Extent: 1 folder

B.2   Lincoln College 1960-1996, n.d.

Scope and Content

Abraham was a Fellow of Lincoln College, 1948-1980, and a member of the College's Finance Committee.

Full range of shelfmarks:

MS. Abraham 10/B.38 - MS. Abraham 11/B.61

Various committee papers and other papers regarding general College business
Date: 1960-1965, n.d.
Shelfmark: MS. Abraham 10/B.38
Language(s) of Material: English
Extent: 1 folder

Lincoln College Appeal
Date: 1972-1993
Shelfmark: MS. Abraham 10/B.39-B.47
Language(s) of Material: English
Extent: 9 folders

Scope and Content

Correspondence etc. The College organised an appeal in 1972 for the conversion of a church into a new library and later sought funds for other projects.

Correspondence and papers regarding general business and activities of the College
Date: 1962-1964, 1974-1996
Shelfmark: MS. Abraham 11/B.48-B.57
Language(s) of Material: English
Extent: 10 folders

Scope and Content

Included are invitations to functions and papers relating to College and committee meetings (Abraham was a member of the Finance Committee).

Restrictions on Access:

Folders B.48 & B.55 closed.


National Research Development Corporation
Date: 1979
Shelfmark: MS. Abraham 11/B.58
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Letter from National Research Development Corporation, with related papers.

Junior Research Fellowships
Date: 1975
Shelfmark: MS. Abraham 11/B.59-B.61
Language(s) of Material: English
Extent: 3 folders

Scope and Content

Copies of papers regarding Junior Research Fellowships at Lincoln College, including accounts of research projects or proposed research.

B.3   Other Colleges and University organisations 1969-1998, n.d.

Full range of shelfmarks:

MS. Abraham 12/B.62 - MS. Abraham 13/B.92

Ashmolean Club
Date: 1990-1998
Shelfmark: MS. Abraham 12/B.62
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence, mostly notices for meetings. Abraham was a Supernumerary Member.

Green College
Date: 1993-1998
Shelfmark: MS. Abraham 12/B.63-B.64
Language(s) of Material: English
Extent: 2 folders

Scope and Content

Correspondence and papers regarding Advisory Council meetings and various events and functions. Abraham was on the College Advisory Council.

Keble College
Date: 1992-1996
Shelfmark: MS. Abraham 12/B.65
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence, etc. regarding appointments of EPA Junior Research Fellows.

Lady Margaret Hall
Date: 1978-1997
Shelfmark: MS. Abraham 12/B.66
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence, etc. regarding Abraham's election to an Honorary Fellowship, invitations to functions, grants to the college by EPA trusts and other matters. Abraham was elected an Honorary Fellow of the college in 1978.

Linacre College
Date: 1983-1996
Shelfmark: MS. Abraham 12/B.67-B.68
Language(s) of Material: English
Extent: 2 folders

Scope and Content

Correspondence, etc. regarding invitations to functions and general business. Abraham was an Honorary Fellow of the college. The EPA Cephalosporin Fund made a donation towards a new residential building at the college.

Natural Sciences Club
Date: 1969-1988
Shelfmark: MS. Abraham 12/B.69-B.71
Language(s) of Material: English
Extent: 3 folders

Scope and Content

Papers and correspondence regardinng meetings, functions and general business. Abraham was a member.

Pembroke College
Date: 1988-1995
Shelfmark: MS. Abraham 12/B.72
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence, etc. regarding invitations to functions and general business. Abraham was a Friend of Pembroke. One or both of the Abraham Trusts donated money to the college.

The Queen's College
Date: 1977-1996
Shelfmark: MS. Abraham 12/B.73-B.74
Language(s) of Material: English
Extent: 2 folders

Scope and Content

Correspondence regarding functions and general business. Abraham was an Honorary Fellow.

St. Cross College
Date: 1983-1990
Shelfmark: MS. Abraham 12/B.75
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence, etc. regarding invitations to functions and other business. One or more of the Abraham trusts appears to have been a benefactor of the college.

St. Hilda's College
Date: 1984-1994
Shelfmark: MS. Abraham 12/B.76
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence, etc. mostly regarding funding of academic posts and functions. Both Abraham trusts were benefactors of the college.

St. Hugh's College / St. Anne's College
Date: 1995, 1997
Shelfmark: MS. Abraham 12/B.77
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Correspondence, mostly regarding invitations to functions. At least one of the Abraham trusts was a benefactor of St. Hugh's College.

St. Peter's College
Date: 1987-1997
Shelfmark: MS. Abraham 12/B.78-B.79
Language(s) of Material: English
Extent: 2 folders

Scope and Content

Correspondence, etc. regarding functions and general business. Abraham was an Honorary Fellow. The EPA Cephalosporin Fund made a donation to the college to help endow an existing Biological Sciences Fellowship.

University Registry and other offices
Date: 1958-1998, n.d.
Shelfmark: MS. Abraham 13/B.80-B.85
Language(s) of Material: English
Extent: 6 folders

Scope and Content

Correspondence, etc. with the Registrar and other offices and individuals within the University.

Topics covered include funding for the Sir William Dunn School of Pathology, Abraham's receipt of an honorary Doctor of Science degree from the University in June 1983, and various events and functions.

University Registry
Date: 1977-1988
Shelfmark: MS. Abraham 13/B.86-B.87
Language(s) of Material: English
Extent: 2 folders

Scope and Content

Correspondence regarding fundraising, events, and general matters.

Safety
Date: 1989-1992
Shelfmark: MS. Abraham 13/B.88
Language(s) of Material: English
Extent: 1 folder

Scope and Content

Papers and correspondence, mostly with the University of Oxford Safety Office, regarding safety procedures associated with work with micro-organisms.

Wolfson College
Date: 1982-1995
Shelfmark: MS. Abraham 13/B.89-B.90
Language(s) of Material: English
Extent: 2 folders

Scope and Content

Correspondence, mostly regarding fundraising and functions. Abraham was an Honorary Fellow of the College and a Patron of its Appeal. The EPA Cephalosporin Fund made a donation to the college.

Miscellaneous correspondence
Date: 1993-1997
Shelfmark: MS. Abraham 13/B.91-B.92
Language(s) of Material: English
Extent: 2 folders

Scope and Content

Correspondence with various Oxford colleges, including Linacre College, and individuals regarding fundraising, donations by the EPA Cephalosporin Fund, and other matters.

C   Research 1935-1995, n.d.

Scope and Content

This section documents a variety of research by Abraham and his colleagues at the Sir William Dunn School of Pathology and by a number of other organisations. The greater part of the material relates to the work on Cephalosporin C and related compounds and the development of marketable cephalosporin antibiotics, though research on penicillin (from 1940), bacilysin and other antibiotics is also covered.

Papers relating to the cephalosporins is dispersed through most of the sub-sections listed below. The correspondence covering the stages of the collaborative research from the late 1940s to the introduction of the first cephalosporin drug in 1964 is chiefly found in the sub-sections 'Medical Research Council', 'National Research Development Corporation' and 'Other Organisations'.

C.1   Early research and research on penicillin 1935-1950, n.d.

Full range of shelfmarks:

MS. Abraham 14/C.1 - MS. Abraham 32/C.206

Dyson Perrins Laboratory notebook
Date: October 1935-c. June 1936
Shelfmark: MS. Abraham 14/C.1
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Mostly regarding experiments involving Undecylenic acid.

Dyson Perrins Laboratory notebook
Date: n.d.
Shelfmark: MS. Abraham 14/C.2
Language(s) of Material: English
Extent: 1 volume

Scope and Content

From front, notes on various experiments; from back, notes on experiments involving lysozyme.

Dyson Perrins Laboratory notebook
Date: n.d.
Shelfmark: MS. Abraham 14/C.3
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Abstracts from papers on various experiments, with references at the end.

Dyson Perrins Laboratory notebook
Date: 1938
Shelfmark: MS. Abraham 14/C.4
Language(s) of Material: English
Extent: 1 volume

Scope and Content

General notes on various compounds and reactions.

Rockefeller Foundation Travelling Fellowship (Stockholm)
Date: 1938-1939
Shelfmark: MS. Abraham 14/C.5
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook detailing experiments involving various enzymes.

Dunn School notebook
Date: January-October 1940
Shelfmark: MS. Abraham 14/C.6
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook detailing experiments involving various substances, including enzymes and intestinal mucosa, and early experiments on penicillin.

Dunn School notebook
Date: November 1940-August 1942
Shelfmark: MS. Abraham 15/C.7
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook detailing various experiments on penicillin and its purification.

Dunn School notebook
Date: August 1942-November 1947
Shelfmark: MS. Abraham 15/C.8
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook detailing experiments on penicillin and related compounds (including penicillanimine), and experiments unrelated to penicillin.

Dunn School notebook
Date: May 1941-1943, October 1949
Shelfmark: MS. Abraham 15/C.9
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook with heading 'Penicillin Analyses' on the first page. From the front: brief notes relating to experimental results on various compounds; from the back: similar notes on compounds, including cephalosporins.

Dunn School notebook
Date: 1941-1946?
Shelfmark: MS. Abraham 15/C.10
Language(s) of Material: English
Extent: 1 volume

Scope and Content

From the front: notes on 'Penicillin Purifications', September 1941 - February 1943 (some later notes may not relate to the heading); from the back: notes regarding experiments on penicillin and related compounds, November 1941-July 1942; notes following the heading 'Penicillin: Mode of Action etc. 10.1.45', January-April 1945; notes following the heading 'Proactinomycin', April-September 1945; 1 further page of notes, January [?1946].

Dunn School notebook
Date: July 1944-May 1945
Shelfmark: MS. Abraham 15/C.11
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook inscribed 'Spiraca and Arctium' on the cover. Partly in Abraham's hand, partly in another's hand. Notes on various experiments.

Dunn School notebook
Date: 1945-1949
Shelfmark: MS. Abraham 15/C.12
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook inscribed 'Abstracts' on the inside cover. Notes on various compounds.

Dunn School notebook
Date: 1945-1949
Shelfmark: MS. Abraham 15/C.13
Language(s) of Material: English
Extent: 1 volume

Scope and Content

General notes headed 'Use of moulds in primitive medicine'. Included at the back is a letter to Abraham regarding arrangements for his lecture on 'Penicillin Chemistry', Oslo, 9 April 1946.

Dunn School notebook
Date: 1948-1950
Shelfmark: MS. Abraham 15/C.14
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notebook (cover missing) entitled 'Penicillin Abstracts'. Notes on penicillin and on various other compounds and processes.

Penicillin reports
Date: n.d.
Shelfmark: MS. Abraham 16/C.15-C.16
Language(s) of Material: English
Extent: 2 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) report; 3 copies of the index to the series, 2 copies include manuscript annotations.

Penicillin reports
Date: January-June 1944
Shelfmark: MS. Abraham 16/C.17-C.26
Language(s) of Material: English
Extent: 10 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 1-106.

Penicillin reports
Date: January-June 1944
Shelfmark: MS. Abraham 17/C.27-C.37
Language(s) of Material: English
Extent: 11 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 107-207.

Penicillin reports
Date: March-October 1944
Shelfmark: MS. Abraham 18/C.38-C.44
Language(s) of Material: English
Extent: 7 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 208-299.

Penicillin reports
Date: March-October 1944
Shelfmark: MS. Abraham 19/C.45-C-56
Language(s) of Material: English
Extent: 12 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 208-299.

Penicillin reports
Date: September 1944-February 1945
Shelfmark: MS. Abraham 20/C.57-C.64
Language(s) of Material: English
Extent: 8 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 300-399.

Penicillin reports
Date: September 1944-February 1945
Shelfmark: MS. Abraham 21/C.65-C.77
Language(s) of Material: English
Extent: 13 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 300-399.

Penicillin reports
Date: December 1944-May 1945
Shelfmark: MS. Abraham 22/C.78-C.88
Language(s) of Material: English
Extent: 11 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 400-502.

Penicillin reports
Date: December 1944-May 1945
Shelfmark: MS. Abraham 23/C.89-C.99
Language(s) of Material: English
Extent: 11 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 400-502.

Penicillin reports
Date: April-August 1945
Shelfmark: MS. Abraham 24/C.100-C.109
Language(s) of Material: English
Extent: 10 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 503-599.

Penicillin reports
Date: April-August 1945
Shelfmark: MS. Abraham 25/C.110-C.121
Language(s) of Material: English
Extent: 12 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 503-599.

Penicillin reports
Date: July 1945-May 1946
Shelfmark: MS. Abraham 26/C.122-C.134
Language(s) of Material: English
Extent: 13 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 600-698.

Penicillin reports
Date: July 1945-May 1946
Shelfmark: MS. Abraham 27/C.135-C.147
Language(s) of Material: English
Extent: 13 folders

Scope and Content

Committee for Penicillin Synthesis (CPS) reports: nos. CPS 600-698.

Papers relating to meetings of the Committee for Penicillin Research.

Penicillin reports
Date: January 1941-July 1945
Shelfmark: MS. Abraham 28/C.148-C.161
Language(s) of Material: English
Extent: 14 folders

Scope and Content

Incomplete series of reports numbered PEN.1 - PEN.150. Some later reports are stamped 'property of the Therapeutic Research Corporation of Great Britain Ltd'.

Penicillin reports
Date: 1942-1945
Shelfmark: MS. Abraham 29/C.162-C.177
Language(s) of Material: English
Extent: 16 folders

Scope and Content

Folders C.162-C.168: Incomplete series of reports numbered PEN.X.1 - PEN.X.54. Some reports are stamped 'property of the Therapeutic Research Corporation of Great Britain'.

Folders C.169-C.177: Incomplete series of reports (copies), numbered PEN.C.3 - PEN.C.107. These reports are mostly by official bodies, such as the National Research Council, and include conference reports.

Penicillin reports
Date: 1942-1945
Shelfmark: MS. Abraham 30/C.178-C.186
Language(s) of Material: English
Extent: 9 folders

Scope and Content

Folders C.178-C.183: Copies of reports entitled 'Ministry of Supply, Penicillin Production Control...Technical Papers Received from USA', 1942-1945. The material includes various different series of reports which were found in a mostly disarranged state. Sequences have been re-constructed where identification was possible.

Included at C.179 is a carbon copy of a typescript by Ernst Chain entitled 'Brief account of the circumstances which led to the discovery of the chemotherapeutic properties of penicillin at the Sir William Dunn School of Pathology, Oxford.

Folders C.184 and C.185: Typescript papers, mostly minutes, etc., regarding the business of the General Penicillin Committee, 1942-1944.

Folder C.186: Correspondence between Sir Robert Robinson and the Therapeutic Research Corporation of Great Britain, October 1942-December 1943; papers regarding meetings on penicillin research, 1942-1943.

Penicillin reports
Date: 1942-1945
Shelfmark: MS. Abraham 31/C.187-C.201
Language(s) of Material: English
Extent: 16 folders

Scope and Content

Miscellaneous reports and other papers, with brief correspondence. The material is mostly typescript, with manuscript papers in an unidentified hand. At C.197 is a letter (1943) from Sir Robert Robinson to Ernst Chain.

Penicillin reports
Date: 1942-1943
Shelfmark: MS. Abraham 32/C.202-C.206
Language(s) of Material: English
Extent: 5 folders

Scope and Content

Contents of a file inscribed 'Penicillin History..Pen Reports..Oxford University'. Copies of typescript reports, 1942-1944. Most of the reports are from the 'PEN.C' series. Included at C.205 is brief correspondence between Sir Robert Robinson and Sir Edward Mellanby, 1943.

C.2   Laboratory notebooks and papers 1946-1983, n.d.

Scope and Content

Binders and notebooks containing manuscript notes, etc., by Abraham and his research assistants at the Sir William Dunn School of Pathology. The material principally documents experiments relating to the development of the cephalosporins and other antibiotics and includes tables of results, graphs, and photographs. The notes are chiefly by research assistants, though many of the binders and notebooks contain notes in more than one hand. 'Cephalosporin' is abbreviated to 'Ceph' on the dividers found in the binders.

Full range of shelfmarks:

MS. Abraham 32/C.207 - MS. Abraham 59/C.286

Notebook
Date: January 1946-July 1948
Shelfmark: MS. Abraham 32/C.207
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notes in an unidentified hand: mostly regarding experiments involving B. Subtilis and ayfivin; a few other notes from back regarding experiments on an antibiotic produced by Staphaur[?eus].

Notebook
Date: July-December 1948
Shelfmark: MS. Abraham 32/C.208
Language(s) of Material: English
Extent: 1 volume

Scope and Content

Notes in the same hand as MS. Abraham 32/C.207. Mostly regarding experiments involving ayfivin, continued from MS. Abraham 32/C.207; a few other notes from the back; 1 loose page of notes the at front dated June 1946.

Large binder
Date: December 1948-November 1953
Shelfmark: MS. Abraham 33/C.209
Language(s) of Material: English
Extent: 1 box

Scope and Content

Notes mostly in Abraham's hand; the remainder in an unidentified hand.

Separated into sections by dividers labelled as follows: 'Alvein' (one page dated February 1949); 'Bacilysin' ([c. April]-May 1949); 'Ayfivin' (December 1948-November 1953); 'Pu[?m]ulin' (February 1951); 'Ageritin' (December 1952); 'Nisin' (June 1950-January 1952); 'Micrococcin' (October [?1951]-January 1952); 'Techniques' (pages dated September 1949, February-March 1950).

Large binder
Date: June 1949-February 1957
Shelfmark: MS. Abraham 34/C.210
Language(s) of Material: English
Extent: 1 box

Scope and Content

Notes partly in Abraham's hand and partly in an unidentified hand.

Separated into sections by dividers labelled as follows: 'Cephalosporin' (June-October 1949); 'Cephalosporin N' (November 1949'-'June 1954); 'Methionine C.14' (June-August 1954); 'Synnematin B' (October 1954); 'Bacitracin' (1955, 1956); 'Ceph N / C14' (September 1955); 'Ceph P' (December 1949-1952, 1957); 'Nonin' (February 1957).

Notebooks
Date: 1949-1953, n.d.
Shelfmark: MS. Abraham 35/C.211-C.212A, C.214
Language(s) of Material: English
Extent: 4 volumes

Scope and Content

C.211: Notebook inscribed 'Margaret Ann Keren Pill', June 1949-March 1950. Notes regarding experiments on various compounds including ayfavin, penicillin and cephalosporins, with index and further notes from back.

C.212: Notebook inscribed 'Ann Pill', 1950-1951. Notes mostly regarding experiments on Cephalosporin N, with index from opposite end.

C.212A: Notebook in the hand of Ann Pill, undated. Headed 'Methods and preparations' on the first page. Brief notes, probably for reference purposes.

C. 214: Paperback notebook inscribed 'M. Read' on the cover, May-October 1953. Contains experimental data (details of the nature of experiments are not given), and general notes on chemistry and human anatomy.

Large binder
Date: 1951-1962
Shelfmark: MS. Abraham 36/C.213
Language(s) of Material: English
Extent: 1 box

Scope and Content

Notes mostly in Abraham's hand; the remainder in an unidentified hand. Separated into sections by dividers labelled as follows:

Notebooks
Date: 1954-1958
Shelfmark: MS. Abraham 37/C.215-C.217
Language(s) of Material: English
Extent: 3 volumes

Scope and Content

C.215: Notebook inscribed 'M.L. Read' on the cover, July 1954 - September 1955. Notes regarding experiments involving various compounds including penicillinase, synnematin and Cephalosporins C and N.

C.216: Notebook inscribed 'M.L. Read' on the cover, October 1955 - October 1956. Notes regarding experiments involving various compounds including penicillinase and Cephalosporins C and N.

C.217: Notebook inscribed 'Mary L. Read' on the cover, October 1956 - January 1958. Notes regarding experiments involving various compounds including secretin, Cephalosporin C, bacitracin and penicillinase.

Notebooks
Date: 1958-1960
Shelfmark: MS. Abraham 38/C.218-C.219
Language(s) of Material: English
Extent: 2 volumes

Scope and Content

C.218: Notebook inscribed 'Mary L. Read' on the cover, January 1958 - December 1958. Notes mostly regarding experiments involving Cephalosporin C.

C.219: Notebook in the hand of Mary L. Read, December 1958-March 1960. Notes mostly regarding experiments involving Cephalosporin C.

Notebooks
Date: 1960-1962
Shelfmark: MS. Abraham 39/C.220-C.221
Language(s) of Material: English
Extent: 2 volumes

Scope and Content

C.220: Notebook inscribed 'M. Loveridge' on the inside cover, March 1960-November 1961. Notes mostly regarding experiments involving Cephalosporin C.

C.221: Notebook inscribed 'M. Loveridge' on the inside cover, November 1961-February 1962. Notes mostly regarding Cephalosporins C and G.

Large binder
Date: 1955-1958
Shelfmark: MS. Abraham 40/C.222
Language(s) of Material: English
Extent: 1 box

Scope and Content

Notes in unidentified hand. Notes mostly regarding experiments involving penicillin and Cephalosporins C and N.

Large binder
Date: 1960-1962
Shelfmark: MS. Abraham 41/C.223
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder labelled 'Ceph C D[ ? ]s 1961', October 1960-July 1962. Notes in an unidentified hand.

At the beginning, there are notes regarding experiments involving various compounds, including α-aminoadipic acid and Cephalosporin C. It is then separated into sections by dividers labelled as follows:

Large binder
Date: 1961-1963
Shelfmark: MS. Abraham 42/C.224, C226
Language(s) of Material: English
Extent: 1 box

Scope and Content

C.224: Notebook inscribed M.L.R. Sharp, September 1961-April 1962. Notes regarding experiments on various compounds including acetic acid, carboxylic acids and Cephalosporin C.

C.226: Notebook in unidentified hand, May-August 1963. Notes mostly regarding the 'Pyo Enzyme Experiment' and the 'X-Press Experiment'.

Large binder
Date: 1962-1963
Shelfmark: MS. Abraham 43/C.225
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder inscribed 'M.L.R. Sharp' on spine, March 1962-December 1963. Separated into sections by dividers labelled as follows:

Large binder
Date: 1963-1965
Shelfmark: MS. Abraham 44/C.227
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder inscribed 'JMT' on spine, October 1963-August 1965. Separated into sections by dividers labelled as follows:

Large binder
Date: 1964-1968
Shelfmark: MS. Abraham 45/C.228
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder inscribed 'GFN Peptides' and 'Takano-san' on the cover and 'G.F. Newton' on the inside cover. The label 'Paul appears on the spine. October 1964-December 1968.

Separated into sections by dividers labelled as follows:

Loose pages of notes and one notebook
Date: 1964-1966
Shelfmark: MS. Abraham 46/C.229-C.233
Language(s) of Material: English
Extent: 1 box

Scope and Content

C.229-C.232: Loose pages of notes, originally from a binder, 1964-1965. Contents of a file inscribed 'Joan Roscoe'. Separated into sections by dividers labelled 'A-H'. Included among numerous topics and experiments are the following:

C.233: Notebook inscribed 'LDS [Leon D. Sabath] Rabbit Expts' on the cover, February 1965-January 1966. Notes regarding the study of penicillin antibodies in rabbits.

Large binder
Date: 1965-1972
Shelfmark: MS. Abraham 47/C.234
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder, January 1965-April 1972, with one page dated 1964. Separated into sections by dividers labelled as follows:

Large binder
Date: 1968-1972
Shelfmark: MS. Abraham 48/C.235
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder labelled 'P.B.[Bronwen] Loder' on the spine. Separated into sections by dividers labelled as follows:

Large binder
Date: 1965-1982
Shelfmark: MS. Abraham 49/C.236
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder labelled 'T.J.B.' on the spine. Notes in Abraham's hand. Separated into sections by dividers labelled as follows:

Large binder
Date: 1966-1969
Shelfmark: MS. Abraham 50/C.237
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder labelled 'J. Walker Bacilysin. Production expts. Early purification expts' on the spine. Separated into sections by dividers labelled as follows:

Large binder
Date: 1968, 1969
Shelfmark: MS. Abraham 51/C.238
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder labelled 'J.E. Walker Bacilysin. Sephadex A25. Large scale purificatn. Compounds P1, P2, P3. Tyrosine. CrCl2 redn'. Separated into topics by dividers labelled as follows:

Laboratory notes
Date: 1968-1970
Shelfmark: MS. Abraham 52/C.239-C.240, C.243-C.250
Language(s) of Material: English
Extent: 10 folders

Scope and Content

C.239 - C.240: 'Amino acid analyses - bacilysin J.E. Walker', contents of a file so inscribed. Chromatogram graphs from experiments by J.E. Walker, with a few accompanying data sheets, 1968, 1969.

C.243 - C.250: Loose pages of notes, originally from a binder, 1968-1970. Contents of a box labelled 'Jeremy and Anne'. Separated into sections by dividers labelled as follows:

Large binder
Date: 1966-1968
Shelfmark: MS. Abraham 53/C.241
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder labelled 'Sylvia Main Book I' on the spine, 1966-1968, with a few notes dated 1965. Separated into sections by dividers labelled as follows:

Large binder
Date: 1967-1968
Shelfmark: MS. Abraham 54/C.242
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder labelled 'Sylvia Main Book II' on the spine'. Separated into sections by dividers labelled as follows:

Loose notes
Date: 1978-1980
Shelfmark: MS. Abraham 55/C.251-C.264
Language(s) of Material: English
Extent: 14 folders

Scope and Content

C.251-C.254: Loose notes, October 1978-November 1980. Contents of a file inscribed 'Synthesis of ISON and conversion of ISON [arrow] Pen[icillin] N by an [?epimerase]. Paginated 1-78, 4 folders. Numerous references indicate that this material was the work of Dr. J.S. Jayatilake.

C.255-C264: Loose notes, 1979, 1980. These notes appear to be a continuation of the material in C.251-C.254. Paginated 78-161 (some material is unpaginated), 10 folders. Separated into sections by dividers labelled as follows:

Loose notes
Date: 1979, 1982-1983
Shelfmark: MS. Abraham 56/C.265-C.267, C.269-C.276
Language(s) of Material: English
Extent: 11 folders

Scope and Content

C.265-C.267: Loose notes, October 1982-February 1983. Contents of a file inscribed 'Synthesis of "cold" & "hot" ACG Attempted labelling expts'. 3 folders.

C.269-C.276: Loose notes, originally from a binder, 1979. Separated into sections by dividers labelled as follows:

Large binder
Date: 1981-1982
Shelfmark: MS. Abraham 57/C.268
Language(s) of Material: English
Extent: 1 box

Scope and Content

Large binder labelled 'GSJ 4 Penicillin chrysogenum. Prepn of extract & experiments'. Separated into sections by dividers labelled as follows:

Loose notes
Date: 1979, 1982-1983
Shelfmark: MS. Abraham 58/C.277-C.282, C.284
Language(s) of Material: English
Extent: 7 folders

Scope and Content

C.277-C.282: Loose notes, 1979. Separated into sections by dividers labelled as follows:

C.284: Notebook inscribed 'C.P. Pang Analytical PAGE Isopenicillin N syn[?e]thetase', June 1982-November 1983. Title on the first page is 'Gel electrophoresis'. This topic appears to cover all the notes in the book.

Notes
Date: 1979, n.d.
Shelfmark: MS. Abraham 59/C.283, C.285- C.286
Language(s) of Material: English
Extent: 3 folders

Scope and Content

C.283: Binder inscribed 'Henry Chmara Amidotransfer' on the cover, 1979 (with a few notes dated 1978 near the back). Topics covered include:

C.285: Notebook in Abraham's hand. From the front: notes regarding visits to universities and institutions in the USA and regarding various chemical processes. From the back: notes on atomic physics, isotopes, and various biochemical processes. References to published sources indicate a possible date of 1948.

C.286: Manuscript numerical data, possibly relating to experiments, n.d.

C.3   Medical Research Council 1949-1985, n.d.

Scope and Content

In July 1949 the MRC's Antibiotics Research Station at Clevedon began to produce culture fluids from the cephalosporium fungus for study by the Sir William Dunn School of Pathology. In early 1952 Abraham's colleague Guy Newton was sent to Clevedon to help speed up the supply of Cephalosporin N. The improved supply enabled Abraham's team to isolate almost pure Cephalosporin N. In 1957, following Glaxo's difficulties in producing sufficient quantities of Cephalosporin C for the Dunn School's requirements, Clevedon workers discovered a mutant strain of the fungus which gave significantly higher yields.

Abraham served on the Scientific Steering Committee to oversee the work of the Antibiotics Research Station, Clevedon.

The majority of the papers relate to the work of the Antibiotics Research Station and its collaboration with the Sir William Dunn School of Pathology.

Full range of shelfmarks:

MS. Abraham 60/C.287 - MS. Abraham 63/C.357

Correspondence
Date: 1949-1961
Shelfmark: MS. Abraham 60/C.287-C.307
Language(s) of Material: English
Extent: 21 folders

Scope and Content

C.287-C.292: Correspondence between Abraham and C.W. Hale of the Antibiotics Research Station, regarding research on cephalosporin, October 1949-December 1952. Included are copies of typescript reports by scientists at the Antibiotics Research Station and the Sir William Dunn School of Pathology. 6 folders.

C.293-C.307: Correspondence, mostly carbon copies of letters from Abraham to B.K. Kelly and G.W. Hale at Clevedon; included also is correspondence between Abraham, the National Research Development Corporation and Glaxo Laboratories Ltd. 1949-1961. 15 folders.

Correspondence, drafts of papers, and reports
Date: 1951-1973, n.d.
Shelfmark: MS. Abraham 61/C.308-C.327
Language(s) of Material: English
Extent: 20 folders

Scope and Content

C.308: Letters by Guy Newton to Abraham, c.[March- May] 1952.

C.309: 1p copy of a typescript abstract of a paper entitled 'Properties of some derivatives of cephalosporin C and heterocyclic tertiary bases', by C.W. Hale, Abraham and G.G.F. Newton, Supplement to International Abstracts of Biological Sciences (IV International Congress of Biochemistry, Vienna, September 1958); letter from Hale, 1958.

C.310: 'The Influence of Methionine on the Biosynthesis of Cephalosporin N', by C.W. Hale, Abraham and G.G.F. Newton. 18pp copy of a typescript draft with manuscript revisions; 2 letters regarding the content and possible publication of the paper, December 1958.

C.311: 'The Cephalosporin C Nucleus (7-Aminocephalosporanic acid)', by G.G.F. Newton and Abraham. Probably published under this title followed by the additional words 'and some of its derivatives', by Bronwen Loder, G.G.F. Newton and Abraham, in Biochemical Journal 79, 1961. 13pp copy of a typescript, with draft figures etc., with the first of the above titles and authors.

C.312: 'Formation of the cephalosporin C nucleus (7-ACA) by enzymic hydrolysis of an N-acyl derivative of 7-ACA' by G.G.F. Newton and Abraham. 5pp copy of a typescript draft with manuscript revisions.

C.313: Copies of typescript appendices, possibly to the papers described in C.309 and C.310.

C.314: 'The Separation of Cephalosporin N and Cephalosporin C', by G.G.F. Newton and Abraham. 8pp copy of a typescript draft with manuscript corrections.

C.315-C.316: Copies of 5 typescripts detailing various experiments, mostly regarding Cephalosporin C, with manuscript revisions and annotations.

C.317: Typescript report by C.W. Hale, December 1956; data and photographic prints (some mounted onto cards).

C.318: Reports by C.W. Hale entitled 'The Extraction of antibiotics produced by Malayan actinomycete', January-March 1951.

C.319-C.320: Various reports, 1957-1959, 1961, n.d.

C.321: Correspondence and committee papers regarding the setting up and business of the Scientific Steering Committee for the work of the Antibiotics Research Station, April 1956-October 1957. (Abraham was a member of the Committee which was formed in May 1956 to act as an advisory body to the Antibiotics Research Station.)

C.322: Miscellaneous correspondence and papers regarding the work of the Antibiotics Research Station, 1956-1958.

C.323-C.327: Correspondence with the National Institute for Medical Research, 1950-1957, regarding various research on antibiotics and the preparation of papers for publication. Correspondents include Martin Pollock.

Correspondence, typescripts, and manuscript notes
Date: 1953-1978
Shelfmark: MS. Abraham 62/C.328-C.341
Language(s) of Material: English
Extent: 14 folders

Scope and Content

C.328-C.333: Correspondence with the National Institute for Medical Research, 1958-1978, regarding various research on antibiotics and the preparation of papers for publication. Correspondents include Martin Pollock.

C.334: Miscellaneous typescripts and manuscript notes and diagrams regarding experiments, some possibly for use in the preparation of publications, 1965, 1968, n.d. Inscriptions on some of the pages indicate collaboration with Glaxo Ltd.

C.335-C.341: Correspondence and papers regarding applications for research grants by Abraham to the Medical Research Council and correspondence arising, 1953-1970. Included is correspondence with other organisations and scientists regarding research topics.

Correspondence and papers
Date: 1971-1985
Shelfmark: MS. Abraham 63/C.342-C.357
Language(s) of Material: English
Extent: 16 folders

Scope and Content

Correspondence and papers regarding applications for research grants by Abraham to the Medical Research Council and correspondence arising. Included is correspondence with other organisations and scientists regarding research topics.

C.4   National Research Development Corporation (NRDC) (British Technology Group (BTG) 1952-1995, n.d.

Scope and Content

In 1949 the NRDC became involved in the research on Cephalosporin, helping to coordinate the results of the work done at Oxford and Clevedon. Following the isolation of Cephalosporin C in 1953, the NRDC persuaded Glaxo Research Laboratories to join the collaboration. After the elucidation of the chemical structure of Cephalosporin C in 1959 the NRDC took steps to exploit the commercial value of the antibiotic by devising a worldwide patenting and licensing strategy. With the subsequent granting of extensions to some of the patents, sales of cephalosporin antibiotics earned the corporation a total of £152 million in royalties which was shared with inventors.

In order to find methods of producing the Cephalosporin C nucleus (7-ACA) in quantity, the NRDC granted options on licences to the pharmaceutical companies Glaxo, Eli Lilly, Squibb, Smith Kline and French, Merck and Pfizer (USA), Ciba and Farmitalia (Europe) and, later, Fujisawa (Japan). With funding from the Corporation new methods were discovered for the large-scale production of 7-ACA and for the conversion of the penicillin to the cephalosporin ring system, enabling a number of different cephalosporins to be produced.

In 1958 Abraham accepted a consultancy position with the NRDC.

The NRDC later combined with the National Enterprise Board to form the British Technology Group.

Full range of shelfmarks:

MS. Abraham 64/C.358 - MS. Abraham 81/C.605

Correspondence
Date: 1952-1960
Shelfmark: MS. Abraham 64/C.358-C.372
Language(s) of Material: English
Extent: 15 folders

Scope and Content

Correspondence, mostly letters to Abraham from the NRDC and patent agents. Included is correspondence regarding Abraham's acceptance of the consultancy position.

Correspondence
Date: 1952-1960
Shelfmark: MS. Abraham 65/C.373-C.392
Language(s) of Material: English
Extent: 20 folders

Scope and Content

Correspondence, etc., mostly carbon copies of letters by Abraham.

Correspondence
Date: 1968-1972
Shelfmark: MS. Abraham 66/C.393-C.413
Language(s) of Material: English
Extent: 21 folders

Scope and Content

Included is correspondence regarding the patent extension granted to the NRDC in 1972. Included are a few letters to, or by, other individuals and companies, and draft affadavits by Abraham, mostly in connection with the patent extension referred to above.

Correspondence
Date: 1973-1975
Shelfmark: MS. Abraham 67/C.414-C.423
Language(s) of Material: English
Extent: 10 folders

Scope and Content

Correspondence, etc. Included are reports on various research topics.

Correspondence
Date: 1976-1977
Shelfmark: MS. Abraham 68/C.424-C.438
Language(s) of Material: English
Extent: 15 folders

Scope and Content

Correspondence, etc. Included are reports on various research topics.

Correspondence
Date: 1978-1980
Shelfmark: MS. Abraham 69/C.439-C.449
Language(s) of Material: English
Extent: 11 folders

Scope and Content

Correspondence, etc. Included are reports on various research topics. Included at C.448 is material relating to a dinner held in honour of Abraham on the occasion of his retirement.

Correspondence
Date: 1981-1983
Shelfmark: MS. Abraham 70/C.450-C.460
Language(s) of Material: English
Extent: 11 folders

Scope and Content

Correspondence, etc. Included are reports on various research topics.

Correspondence
Date: 1958-1995
Shelfmark: MS. Abraham 71/C.461-C.480
Language(s) of Material: English
Extent: 20 folders

Scope and Content

Correspondence, etc.

Correspondence
Date: 1962-1966
Shelfmark: MS. Abraham 72/C.481-C.503
Language(s) of Material: English
Extent: 23 folders

Scope and Content

Correspondence, etc.

Correspondence
Date: 1965-1968
Shelfmark: MS. Abraham 73/C.504-C.519
Language(s) of Material: English
Extent: 16 folders

Scope and Content

Correspondence, etc.

Correspondence, assignments, and agreements
Date: 1954-1988
Shelfmark: MS. Abraham 74/C.520-C.532
Language(s) of Material: English
Extent: 13 folders

Scope and Content

C.520-C.523: Miscellaneous correspondence. etc., with BTG, 1983-1985, 1988.

C.524-C.532: Copies of assignments and agreements (involving Abraham, Guy Newton, the NRDC and others), with related papers and correspondence, 1954-1967.

Accounts, patent specifications, and reports
Date: 1959-1963
Shelfmark: MS. Abraham 75/C.533-C.545
Language(s) of Material: English
Extent: 13 folders

Scope and Content

C.533-C.534: Accounts produced in accordance with the cephalosporin revenue sharing agreements, with related papers and correspondence, 1959-1963.

C.535-C.540: Copies of draft patent specifications for applications filed by Abraham, Guy Newton and the NRDC, 1959-1962.

C.541-C.545: Copies of typescript reports, some co-authored by Abraham, on developments in Cephalosporin C research, with other papers concerning patents, 1959-1962.

'Cephalosporin C Dossier'
Date: 1959-1964, n.d.
Shelfmark: MS. Abraham 76/C.546-C.557
Language(s) of Material: English
Extent: 12 folders

Scope and Content

Copies of numbered typescript reports by scientists at the Sir William Dunn School of Pathology (including Abraham) and the MRC's Antibiotics Research Station.

'Cephalosporin C Dossier'
Date: 1957-1966, n.d.
Shelfmark: MS. Abraham 77/C.558-C.569
Language(s) of Material: English
Extent: 12 folders

Scope and Content

Copies of numbered typescript reports by scientists at the Sir William Dunn School of Pathology (including Abraham) and the MRC's Antibiotics Research Station.

Typescript research reports
Date: 1969-1973
Shelfmark: MS. Abraham 78/C.570-C.583
Language(s) of Material: English
Extent: 14 folders

Scope and Content

C.570-C.574: Copies of typescript 'Reports to the NRDC on Biochemical Studies Relating to Cephalosporins and Penicillins' by the Sir William Dunn School of Pathology, one with manuscript revisions by Abraham, 1969-1973.

C.575-C.583: Copies of typescript research reports on the cephalosporins and B-lactamases by Abraham and others, 1969.

Patents
Date: 1953-1971, n.d.
Shelfmark: MS. Abraham 79/C.584-C.591
Language(s) of Material: English
Extent: 8 folders

Scope and Content

C.584: Copy of a legal brief relating to a dispute over patents between Dr. H.S. Burton and his ex-colleagues at the Sir William Dunn School of Pathology, 1961.

C.585-C.587: Schedules of patents and patent applications concerning Cephalosporin C, 1960-1971.

C.588-C.591: Miscellaneous papers and correspondence, mostly regarding patents. 1953-1958, n.d.

Patents
Date: 1959-1992, n.d.
Shelfmark: MS. Abraham 80/C.592-C.604
Language(s) of Material: English
Extent: 13 folders

Scope and Content

Miscellaneous papers and correspondence, mostly regarding patents.

'Cephalosporin Analogue 87/4'
Date: c.1964-1970
Shelfmark: MS. Abraham 81/C.605
Language(s) of Material: English

Scope and Content

'Cephalosporin Analogue 87/4', a large printed document so entitled, produced by Glaxo Group Ltd., containing detailed experimental results and technical information.

C.5   Other organisations 1946-1994, n.d.

Scope and Content

Correspondence and papers, mostly relating to the various stages in the research on Cephalosporin C and other work on B-lactam antibiotics. The organisations are mostly pharmaceutical companies.

Arrangement

Arranged alphabetically by organisation.


Full range of shelfmarks:

MS. Abraham 82/C.606 - MS. Abraham 103/C.963

Beecham-Distillers
Date: 1946-1994, n.d.
Shelfmark: MS. Abraham 82/C.606-C.624
Language(s) of Material: English
Extent: 19 folders

Scope and Content

C.606-C.614: Beecham Group plc., 1970-1991, n.d. Beecham was a manufacturer of semi-synthetic penicillins. In 1959 the company succeeded in isolating the penicillin nucleus '6-APA'.

Correspondence, mostly regarding requests for chemical samples for research and exchanges of information. Included are correspondence and papers regarding the Beecham Colloquium (September 1981): at C.612 is a copy of a transcript of a discussion at the colloquium 'The Control of Antibiotic-resistant bacteria', in which Abraham participated; and a proof, with manuscript corrections, of a paper 'The Design of New Antibiotics and Bacterial Resistance' by Abraham, probably given at the colloquium. Also included at C.614 is correspondence regarding Abraham's assistance to Beecham in patent litigation.

C.615: Bristol-Myers Company (USA), 1973, 1978-1987. Correspondence regarding studies on B-lactam antibiotics.

C.616-C.620: CIBA Ltd., 1961-1966, 1973-1975. CIBA was one of the companies granted a licence by the NRDC in the 1960s to research methods of producing the Cephalosporin C nucleus. Correspondence and papers: included at C.618 and C.619 are manuscript and typescript drafts (some incomplete) of Abraham's lecture entitled, 'Preliminary Experiments on the Biosynthesis of Cephalosporin C', with related correspondence. Also at C.619 is a copy of a 3pp typescript of a talk by Abraham entitled 'Gordon Conference'.

C.621-C.624: The Distillers Company Ltd., 1949, 1953-1963. In the 1950s Distillers produced quantities of cephalosporin for use by the Sir William Dunn School of Pathology. The company reached an agreement with the NRDC (1959) for research into Cephalosporin C. Correspondence etc.: included is material relating to a patent dispute between Beecham Research Laboratories Ltd. and Distillers.

Dyson Perrins-Eli Lilly
Date: 1954-1991
Shelfmark: MS. Abraham 83/C.625-C.642
Language(s) of Material: English
Extent: 18 folders

Scope and Content

C.625-C.632: Dyson Perrins Laboratory (Oxford), 1971, 1978-1991. The 1970s and 1980s saw various collaborative projects on the biosynthesis of penicillins and cephalosporins involving the Dyson Perrins Laboratory, the Sir William Dunn School of Pathology and Eli Lilly (see C.633-C.881).

Correspondence and papers: included is correspondence with Jack Baldwin regarding research on biosynthesis of penicillins and cephalosporins and related articles. Some correspondence relates to appointments to research and other posts, including refereeing. At C.628-C.630 are manuscript and typescript drafts of an article by Abraham and Baldwin 'The Biosynthesis of Penicillins and Cephalosporins', Natural Products Reports 5 (Royal Society of Chemistry), 1988, with correspondence regarding publication.

C.633-C.642: Eli Lilly and Company.

Eli Lilly signed an agreement with the NRDC in January 1959 for a research programme aimed at producing substances related to Cephalosporin C (including its nucleus). This project was unsuccessful, but in early 1960 the NRDC granted the company an option on a licence allowing it to research processes of converting Cephalosporin C to its nucleus (7-ACA). It was the only licensee to achieve a breakthrough in this area, paving the way for large-scale production of the nucleus. Eli Lilly introduced its first cephalosporin antibiotic in 1964. In the following years Eli Lilly funded collaborative research projects on the biosynthesis of penicillins and cephalosporins involving the Sir William Dunn School of Pathology and the Dyson Perrins Laboratory (see C.625-C.632).

Correspondence, 1954, 1957-1962. Some correspondence, 1957-1959, relates to the preparation of crude secretin.

Restrictions on Access:

Folder C.626 closed.


Eli Lilly (continued)
Date: 1965-1971
Shelfmark: MS. Abraham 84/C.643-C.662
Language(s) of Material: English
Extent: 20 folders

Scope and Content

Correspondence, with related papers, mostly regarding research on cephalosporins. Included at C.653-C.659 are manuscript and typescript drafts, some incomplete and disarranged (with proof at C.661), of a paper entitled 'Cephalosporin C' by Abraham and P.B. Loder in Cephalosporins and Penicillins: Chemistry and Biology, ed. by E.H. Flynn, New York 1972. Related correspondence is at C.649-652 and C.660-C.662.

Eli Lilly (continued)
Date: 1972-1985
Shelfmark: MS. Abraham 85/C.663-C.686
Language(s) of Material: English
Extent: 24 folders

Scope and Content

Correspondence, with related papers, mostly regarding research on cephalosporins. At C.683 is a copy of a typescript of Abraham's introduction to Chemistry and Biology of B-lactam Antibiotics (Volume 1), edited by Robert B. Morin and Marvin Gorman, New York and London, 1982. At C.684 is a proof with corrections of 'Biosynthesis of Penicillins and Cephalosporins', a chapter by Abraham in Beta-Lactam Antibiotics for Clinical Use, Clinical Pharmacology 4, edited by Sherry F. Queener et al., New York 1986.

Eli Lilly (continued)
Date: 1986-1990
Shelfmark: MS. Abraham 86/C.687-C.697
Language(s) of Material: English
Extent: 11 folders

Scope and Content

C.687-C.694: Correspondence, with related papers, mostly regarding research on cephalosporins, 1986-1990.

C.695-C.697: Drafts and copy of an agreement, December 1985, between Eli Lilly, the University of Oxford, Abraham and Jack Baldwin relating to co-operation on the B-lactam Biosynthesis Project, with correspondence, etc., regarding the agreement and related matters, 1985, 1986.

Eli Lilly (continued)
Date: 1975-1979
Shelfmark: MS. Abraham 87/C.698-C.714
Language(s) of Material: English
Extent: 17 folders

Scope and Content

Experimental notes, separated by dividers labelled as follows:

Eli Lilly (continued)
Date: 1975-1979
Shelfmark: MS. Abraham 88/C.715-C.724
Language(s) of Material: English
Extent: 10 folders

Scope and Content

Experimental notes, separated by dividers labelled as follows:

Eli Lilly (continued)
Date: 1975-1978
Shelfmark: MS. Abraham 89/C.725-C.734
Language(s) of Material: English
Extent: 10 folders

Scope and Content

Experimental notes, separated by dividers labelled as follows:

Eli Lilly (continued)
Date: 1975-1976
Shelfmark: MS. Abraham 90/C.735-C.746
Language(s) of Material: English
Extent: 12 folders

Scope and Content

Experimental notes, separated by dividers labelled as follows:

Eli Lilly (continued)
Date: 1975-1976
Shelfmark: MS. Abraham 91/C.747-C.757
Language(s) of Material: English
Extent: 11 folders

Scope and Content

Experimental notes, separated by dividers labelled as follows:

Eli Lilly (continued)
Date: 1975-1978
Shelfmark: MS. Abraham 92/C.758-C.778
Language(s) of Material: English
Extent: 21 folders

Scope and Content

Experimental notes, separated by dividers labelled as follows:

Included at C.758 are a few letters to Abraham from Douglas Young of Sussex University, 1975-1977.

Included at C.759 is copy of a 9pp draft of paper entitled 'The Stereochemistry of B-lactam Formation in Cephalosporin Biosynthesis', by Abraham, Joyce A. Huddleston et. al., Biochemical Journal 169, 1978

Eli Lilly (continued)
Date: 1976-1979
Shelfmark: MS. Abraham 93/C.779-C.793
Language(s) of Material: English
Extent: 15 folders

Scope and Content

Experimental notes, separated by dividers labelled as follows:

Eli Lilly (continued)
Date: 1975-1978
Shelfmark: MS. Abraham 94/C.794-C.811
Language(s) of Material: English
Extent: 18 folders

Scope and Content

Experimental notes, separated by dividers labelled as follows:

Eli Lilly (continued)
Date: 1977-1979
Shelfmark: MS. Abraham 95/C.812-C.824
Language(s) of Material: English
Extent: 13 folders

Scope and Content

Experimental notes, separated by dividers labelled as follows:

Eli Lilly (continued)
Date: 1977-1978
Shelfmark: MS. Abraham 96/C.825-C.833
Language(s) of Material: English
Extent: 9 folders

Scope and Content

Experimental notes, separated by dividers labelled as follows:

Eli Lilly (continued)
Date: 1985-1989
Shelfmark: MS. Abraham 97/C.834-C.849
Language(s) of Material: English
Extent: 16 folders

Scope and Content

C.834: 'Isolation, sequence determination and expression in Escherichia coli of the Isopenicillin N-synthetase gene from Cephalosporium acremonium', by Abraham et al., Nature 318, 1985. 2 copies of typescripts, one headed 'working copy' with manuscript revisions, the other headed 'final copy' and a letter regarding publication.

C.835-C.849: Drafts and copies of various reports and papers regarding the exchange of information between Eli Lilly and Oxford, 1985-1989. None of the reports appear to be by Abraham, though his manuscript revisions are found on some.

Eli Lilly (continued)
Date: 1985-1989
Shelfmark: MS. Abraham 98/C.850-C.865
Language(s) of Material: English
Extent: 16 folders

Scope and Content

Drafts and copies of various reports and papers regarding the exchange of information between Eli Lilly and Oxford, 1985-1989. None of the reports appear to be by Abraham, though his manuscript revisions are found on some.

Eli Lilly (continued)
Date: 1961-1994
Shelfmark: MS. Abraham 99/C.866-C.881
Language(s) of Material: English
Extent: 16 folders

Scope and Content

C.866: 'Acyl coenzyme A: 6-aminopenicillanic acid acyltransferase from penicillin chrysogenum and aspergillus nidulans', by Abraham et al., FEBS Letters 262, 1990. 6pp copy of a typescript of paper.

C.867-C.874: 'Isolation of deacetoxycephalosporin C from fermentation broths of penicillium chrysogenum transformants: construction of a new fungal biosynthetic pathway', by Abraham et al., Proceedings of the Royal Society B 248, 1992. Correspondence regarding preparation and publication of the paper, September 1991-December 1992. Included are typescript drafts, some with manuscript revisions by Abraham. Also includes material printed out from a floppy disc found with the papers.

C.875: 2pp manuscript draft by Abraham, entitled 'The Production of Cephalosporins by a Transformant of Penicillium chrysogenum', of an introduction for a paper, with a revised typescript version and a further 1p typescript draft. Possibly early drafts of the paper 'Production of deacetoxycephalosporin C by transformants of Penicillium chrysogenum: antibiotic pathway engineering', by Abraham et al., Industrial Microorganisms (possibly a publication by the American Society of Microbiology), [?1993].

C.877-C.879: Miscellaneous correspondence, with reports, regarding progress of research, 1988-1991, 1994.

C.880-C.881: Miscellaneous typescript reports, etc., by the Lilly Research Laboratories, 1961, 1962, 1971.

Glaxo Group, Ltd.
Date: 1957-1968
Shelfmark: MS. Abraham 100/C.882-C.897
Language(s) of Material: English
Extent: 16 folders

Scope and Content

In 1956 the NRDC arranged for Glaxo to join in the research on Cephalosporin C, chiefly to find ways of increasing the yields of the antibiotic from strains of the cephalosporium fungus. This was achieved after much painstaking work involving repeated mutations of the mould. Glaxo's huge investment in the research bore fruit in 1964, with the introduction of its drug 'Ceporin' ('cephaloridine') into medicine.

C.882-C.889: Correspondence regarding cephalosporin nomenclature, 1957-1964.

C.890-C.897: Included at C.891 and C.892 are a draft and a later copy of the script of a Glaxo film entitled 'Antibiotic from the sea'. Abraham assisted in the production of the script and appeared in the film, though not as a speaker. Also included is correspondence regarding the Conference on Cephalosporidine at New College Oxford, 13-16 March 1967, which Abraham attended; at C.895 is a copy of a typescript of an introductory talk given by Abraham at the conference entitled 'Cephaloridine. Historical Remarks'.

Glaxo Group, Ltd. (continued) / Imperial Chemical Industries Ltd. (ICI)
Date: 1953-1988
Shelfmark: MS. Abraham 101/C.898-C.921
Language(s) of Material: English
Extent: 24 folders

Scope and Content

C.898-C.905 (Glaxo): Included is correspondence, etc., regarding the International Conference on Cephalosporins, Brighton, 11-13 May 1970, in which Abraham participated. At C.901 is a copy of a typescript draft of a review of the conference by Abraham and P.B. Loder: 'Cephalosporins', Postgraduate Medical Journal, Supplement vol. 46, October 1970. (1969-1972)

C.906-C.913 (Glaxo): Included is correspondence regarding a proposal by Glaxo to enter into a collaborative research project (which the company would finance) with the Sir William Dunn School of Pathology. (1973-1985)

C.914-C.921 (ICI): Abraham held a consultancy position with ICI, 1955-1958. Scientific correspondence regarding research on the cephalosporins and other antibiotics, 1953-1963, 1970, 1981-1988. Mostly 1953-1963.

Merck & Co. Inc. / Microbiological Research Station / Pfizer Inc. (Chas. Pfizer & Co. Inc.)
Date: 1948-1992
Shelfmark: MS. Abraham 102/C.922-C.943
Language(s) of Material: English
Extent: 22 folders

Scope and Content

C.922-C.928 (Merck & Co. Inc.): Merck was one of the companies licensed by the NRDC in the early 1960s to work on the production of the Cephalosporin C nucleus. Correspondence regarding research on Cephalosporin C and other antibiotics, 1950, 1953, 1958-1981.

C.929-C.940 (Microbiological Research Station, Porton Down): The station supplied microorganisms and microbial products to research workers. In 1961 it began a Cephalosporin C production project to assist with the research programme overseen by the NRDC. Correspondence, with copies of reports, regarding work on Cephalosporin C and B-lactamases, 1948, 1950, 1956-1978, 1992. Mostly 1959-1978.

C.941-C.943 (Chas. Pfizer & Co. Inc.): Pfizer was one of the companies licensed by the NRDC in the early 1960s to work on the production of the Cephalosporin nucleus. Correspondence regarding research on Cephalosporin C and other antibiotics, 1960-1962, 1977, 1978, 1985, 1986. Mostly 1960-1962.

Smith, Kline & French Laboratories / Squibb Institute of Medical Research / Upjohn Co.
Date: 1946-1983
Shelfmark: MS. Abraham 103/C.944-C.963
Language(s) of Material: English
Extent: 20 folders

Scope and Content

C.944-C.945 (Smith, Kline & French Laboratories): Smith Kline & French was one of the companies licensed by the NRDC in the early 1960s to work on the production of the Cephalosporin C nucleus. Correspondence etc, mostly regarding research on Cephalosporin C, 1960-1962, 1972-1975.

C.946-C.962 (Squibb Institute of Medical Research): Squibb was one of the companies licensed by the NRDC in the early 1960s to work on the production of the Cephalosporin C nucleus.

C.946-C.949: Correspondence and papers regarding Cephalosporin C and proposed visits and conferences, etc., 1946, 1957-1966. Included is correspondence regarding arrangements for Abraham's participation in the Sixth Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Philidelphia, USA, October 1966.

C.950-C.951: Correspondence. etc., chiefly regarding a legal case involving E.R. Squibb and Sons Inc, 1971. Included is a draft of an affadavit by Abraham in connection with this case.

C.952-C.960: Lectures by Abraham: the Squibb Lectures for 1972 at Rutgers University, New Jersey, 20, 21 September; and at the annual meeting of the Infectious Diseases Society of America, Atlantic City, 25-27 September 1972.

C.952: Correspondence regarding arrangements for both events and correspondence arising, 1971, 1972.

C.953: 'Biosynthesis of Penicillins and Cephalosporins', first Squibb lecture. In the published version the title of the lecture is 'Aspects of the Biosynthesis of Penicillins and Cephalosporins'. 26pp manuscript draft with revisions and a copy of the revised typescript version with addenda.

C.954-C.957: 'B-lactamases and their Role in Resistance to B-lactam Antibiotics', second Squibb Lecture. 58pp typescript draft, with manuscript revisions, and figures etc., and a copy of proof with corrections.

C.958: Lecture given at the annual meeting of the Infectious Diseases Society of America as a contribution to the topic 'Enzymic Degradation of Antibiotics'. 47pp manuscript draft with revisions entitled 'Enzymic Degradations of the Penicillins and Cephalosporins', with 4 further pages, possibly part of another draft version; typescript tables and data, etc., probably relating to the lecture.

C.959-C.960: Correspondence arising from the lectures, chiefly regarding the publication of the Squibb Lectures, October 1972-March 1974.

C.961-C.962: Correspondence, etc., regarding general matters, 1974-1983.

C.963 (Upjohn Co.): Correspondence in connection with the company's research on antibiotics, 1954, 1959-1968, 1973.

C.6   Scientific correspondence 1955-1983

Scope and Content

Correspondence, and related material, between Abraham and scientists in British universities regarding research on B-lactamases and various antibiotics. Included is correspondence of a more general nature, including some regarding appointments, etc.

Full range of shelfmarks:

MS. Abraham 104/C.964 - MS. Abraham 104/C.989

Scientific correspondence
Date: 1955-1983
Shelfmark: MS. Abraham 104/C.964-C.989
Language(s) of Material: English
Extent: 24 folders

Scope and Content

C.964-C.964 University of Cambridge: Correspondence with scientists, chiefly in the School of Biochemistry and the Medical Research Council Unit for Chemical Microbiology, regarding various research on antibiotics, 1955-1965. The principal correspondent is Ernest F. Gale.

C.966-C.967 University of Cambridge: General and scientific correspondence, 1971-1981. Included is correspondence regarding arrangements for the Roche Symposium on 'Aspects of Peptides and Protein Chemistry', 29 November 1971, attended by Abraham.

C.968-C.972 University of Edinburgh: Correspondence regarding research on B-lactamases, 1965-1981. The principal correspondent is Martin Pollock. General correspondence is included.

C.973-C.976 University of Newcastle-upon-Tyne: Correspondence, chiefly with R.J. Stoodley of the School of Chemistry, regarding research on B-lactamases, 1974-1983. Includes correspondence regarding arrangements for a lecture by Abraham at the University, November 1974, and a B-lactamase workshop, April 1979.

C.977-C.986 University of Sheffield: Correspondence and papers regarding research on actinonin, 1962-1968, 1974. Almost all the material is 1962-1968. The NRDC funded work on actinonin undertaken jointly by Abraham's department and chemists at the University of Sheffield working under David Ollis, Professor of Organic Chemistry.

C.987-C.988 University of Surrey: Correspondence regarding biosynthesis of penicillins and other research on B-lactam antibiotics, 1972, 1973, 1979-1981. The principal correspondent is Robert Thomas. Included is a typescript draft with manuscript corrections (in a hand other than Abraham's) of a paper entitled 'The Interaction of Nocardicins with B-Lactamase II', by Abraham et al. (publication details unknown).

C.989 University of Sussex: Correspondence mostly regarding research involving chiral cysteines, 1973-1982. The principal correspondent is Douglas Young of the School of Molecular Sciences.

Restrictions on Access:

Folders C.965 & C.971 closed.


C.7   Bacilysin research 1957-1991

Scope and Content

The antibiotic bacilysin, produced by a number of strains of Bacilus subtilis, was first encountered by Abraham and his co-workers in 1946. Preliminary work on the production and purification of bacilysin was carried out by Abraham and Guy Newton, but the work ended in 1948 due to insufficient resources and the Dunn School's increasing interest in cephalosporins. Abraham and his colleagues returned to research on this antibiotic in the early 1960s.

Full range of shelfmarks:

MS. Abraham 105/C.990 - MS. Abraham 105/C.1016

Bacilysin research
Date: 1957-1991
Shelfmark: MS. Abraham 105/C.990-C.1016
Language(s) of Material: English
Extent: 27 folders

Scope and Content

C.990-C.995: Correspondence, etc., regarding research on bacilysin and related substances, 1957, 1962-1975, 1981-1991. The correspondents comprise Abraham's colleagues and other scientists working in various countries.

C.996-C.1009: Published papers, 1965-1970 or [?after].

C.996-C.997: 'Production and Purification of Bacilysin', by Abraham, G.G.F. Newton and H.J. Rogers, Biochemical Journal 97, 1965. 13pp manuscript draft with revisions; later typescript draft with manuscript revisions (including draft figures). Proof with manuscript corrections; offprint with manuscript annotations.

C.998-C.999: 'Observations on the Structure of Bacilysin' by Abraham et al., Biochemical Journal 97, 1965. 24pp typescript draft, with manuscript revisions, and draft figures, and proof.

C.1000: 'Experiments relating to the Biosynthesis of Bacilysin', by Abraham and J. Roscoe, Biochemical Journal 99, 1966. 21pp manuscript draft with revisions; later incomplete 2pp typescript draft with manuscript revisions; offprint.

C.1001: 'Isolation of Bacilysin and a New Amino Acid from Culture Filtrates of Bacillus subtilis', by Abraham and J.E. Walker, Biochemical Journal 118, 1970. Copy of 11pp typescript and figures, etc; proof.

C.1002-C.1003: 'The Structure of Bacilysin and Other Products of Bacillus subtilis', by Abraham and J.E. Walker, Biochemical Journal 118, 1970. 15pp typescript draft, with manuscript revisions, and legends for figures etc. Copy of revised typescript and proof.

C.1004: 'Antibiotic Production and Sporulation in B. subtilis', by Abraham and J.E. Walker, [?1970 or after]. Publication details unknown. 7pp typescript draft with manuscript revisions.

C.1005: 'Effect of Bacilysin on Certain Fungi and Yeasts', by Abraham and J.E. Walker, [?1970 or after]. Publication details unknown. 2pp typescript draft, possibly incomplete, with manuscript revisions; copy of typescript revised version, with photographs for figures.

C.1006: 'Carbobenzoxy Derivative of Bacilysin', by Abraham and J.E. Walker, [?1970 or after]. Publication details unknown. Copy of 2pp typescript and photographs for figures.

C.1007: 25pp untitled manuscript draft of paper regarding experiments on bacilysin, with revisions, [?1970 or later].

C.1008-C.1009: Untitled drafts of paper regarding experiments on bacilysin, [?1970 or after]. 35pp typescript draft of main text with manuscript revisions. Part of another typescript draft of the paper with manuscript revisions; copy of typescript draft, with manuscript revisions, of captions for figures etc, with photographs.

C.1010-C.1011: Correspondence with various scientists and organisations regarding research on bacilysin, 1962-1965. A few letters relate to the preparation of some of the papers in C.996-C.1009.

C.1012-C.1014: Reports, experimental results and research programmes, etc., regarding studies on bacilysin compiled by Abraham and his co-workers, 1962-1965, c.1966. Mostly typescript, some with manuscript annotations.

C.1015, C.1016: Miscellaneous notes and data, mostly manuscript, some possibly relating to the preparation of the papers in C.996-C.1009.

C.8   Legal cases 1978-1989

Scope and Content

Papers and correspondence relating to Abraham's involvement in legal cases between pharmaceutical companies in the USA. The disputes concerned patents for cephalosporin antibiotics.

Full range of shelfmarks:

MS. Abraham 106/C.1017 - MS. Abraham 108/C.1037

Eli Lilly and Company v Premo Pharmaceutical Laboratories
Date: 1978-1980
Shelfmark: MS. Abraham 106/C.1017-C.1025
Language(s) of Material: English
Extent: 9 folders

Scope and Content

The dispute was over an alleged infringement of an Eli Lilly patent relating to cephalexin. Abraham appeared in court as an expert witness for Eli Lilly. Correspondence and copies of documents relating to the case. Documents include affadavits by Abraham and a copy of his testimony.

Legal cases
Date: 1978-1980, 1986-1989
Shelfmark: MS. Abraham 107/C.1026-C.1035
Language(s) of Material: English
Extent: 10 folders

Scope and Content

C.1026-C.1030: Eli Lilly and Company v Premo Pharmaceutical Laboratories, 1978-1980. Correspondence and copies of documents relating to the case.

C.1031: Material for draft of unidentified paper: mostly photographs mounted onto pieces of paper, with captions, and loose photographs. Found with the papers in C.1017-C.1030.

C.1032-C.1035: Correspondence and papers regarding legal disputes concerning a patent for crystalline cefadroxil monohydrate belonging to the Bristol-Myers Company, 1986-1989. The material chiefly relates to the case Bristol-Myers Company v Biocroft Laboratories Inc., 1987. Abraham sent a declaration on behalf of Bristol-Myers.

Exhibits
Date: 1986
Shelfmark: MS. Abraham 108/C.1036-C.1037
Language(s) of Material: English
Extent: 2 folders

Scope and Content

'Exhibits to the Declaration of Sir Edward P. Abraham' and 'Exhibits to the Declaration of Jack E. Baldwin'.

C.9   Cephalosporin C history 1948-1995, n.d.

Full range of shelfmarks:

MS. Abraham 109/C.1038 - MS. Abraham 110/C.1067

Cephalosporin C history
Date: 1948-1964
Shelfmark: MS. Abraham 109/C.1038-C.1053
Language(s) of Material: English
Extent: 16 folders

Scope and Content

C.1038-C.1041: Correspondence and papers mostly relating to the early years of the Sir William Dunn School of Pathology's research on antibiotics from the cephalosporium fungus, 1948-1949, 1952, 1961. Included is correspondence between Howard Florey and Dr. Blythe Brooke, who in 1948 was asked by Professor Giuseppe Brötzu to notify scientists in Britain of the latter's work on cultures from cephalosporium; correspondence between Florey and Brötzu; and detailed report and summary of work done by the Dunn School from December 1948-March 1949.

C.1042-C.1048: Correspondence between Abraham and various organisations and individuals covering the different stages of the research on Cephalosporin C, with related papers, 1952-1964. Correspondents include Guy Newton, the NRDC, and the Antibiotics Research Station of the Medical Research Council.

C.1049-C.1053: Papers relating to a petition by the NRDC, c. 1958-1960, to the Comptroller of Patents for him to require Dr. H.S. Burton to join other inventors in assigning the Cephalosporin N patent to the NRDC. Burton was formerly a junior colleague of Abraham who worked on Cephalosporin P and during the early research on Cephalosporin N. He subsequently claimed that his contribution to the work on Cephalosporin N should have entitled him to inclusion in patents other than Letters Patent Number 745208.

C.1049-C.1050: Contents of a file labelled 'Statement, counterstatement and evidence on behalf of Sir Howard Florey and others'. Copies of declarations, statements, etc,, with other documents used for reference, 1952-1959.

C.1051-C.1052: Contents of a file inscribed 'Evidence in reply on behalf of Sir Howard Florey and others', 1949-1960.

C.1053: Copy of 'Comptroller's Report on the application of NRDC to direct H.S. Burton to join with others in assigning the Cephalosporin N (Penicillin N) patent to NRDC', 1962; newspaper cutting relating to this application or a case closely connected with it.

Cephalosporin C history
Date: 1952-1995, n.d.
Shelfmark: MS. Abraham 110/C.1054-C.1067
Language(s) of Material: English
Extent: 14 folders

Scope and Content

C.1054: 'A New Type of Penicillin from a Species of Cephalosporium', by Abraham and Guy Newton, VI International Congress of Microbiology, Rome 1953, Riassunti delle Communicazioni, Vol. 1. 3pp typescript draft of the paper with manuscript revisions.

C.1055: 'Isolation of Penicillamic Acid and D-α-aminoadipic acid from Cephalosporin N', by Abraham and Guy Newton, Nature 172, 1953.

C.1056: 'Cephalosporin N: a New Type of Penicillin', by Abraham et al., Nature 629. Proof of article, n.d.

C.1057: 2 typescript reports on Cephalosporin N research at the Sir William Dunn School and the Antibiotics Research Station, with manuscript annotations or corrections, 1952-c.1958.

C.1058: Brief correspondence regarding Abraham's requests for chemical samples from overseas universities, 1953.

C.1059: Typescript lecture programme on Bacteriology and Immunity at the Sir William Dunn School of Pathology, Trinity Term, 1959.

C.1060-C.1062: Correspondence and papers, including a copy of an affadavit by Abraham (and copy of his affadavit for an earlier petition), regarding the petition of the NRDC to extend the term of a patent (Letters Patent No. 953695), 1976. The patent concerned the Cephalosporin C nucleus (7-ACA). The petition was successful, the term being extended for four years.

C.1063: Royal Society Conversazione 23 June 1977. 3pp typescript by Abraham and S.G. Waley entitled 'The Development of the Cephalosporin Family of Antibiotics' for exhibit at the Conversazione.

C.1064: 'A Glimpse of the Early History of the Cephalosporins', a speech by Abraham at the Harvard Club dinner, May 1978. Copy of 19pp typescript of speech.

C.1065-C.1067: Miscellaneous correspondence regarding cephalosporin research and the history of Cephalosporin C, 1962-1979, 1995. Included at C.1066 is a script for a BBC External Services radio programme 'Report from Britain no. 151', 1965, which mentions Abraham's work and includes a quote by him.

C.10   Miscellaneous papers 1945-1991, n.d.

Full range of shelfmarks:

MS. Abraham 111/C.1068 - MS. Abraham 116/C.1114

Miscellaneous papers
Date: 1948-1990
Shelfmark: MS. Abraham 111/C.1068-C.1082
Language(s) of Material: English
Extent: 15 folders

Scope and Content

C.1068: Abraham's 'Report to the Rockefeller Foundation on activities in the USA during the tenure of a Fellowship from April to October 1948. Copy of a 19pp typescript draft with manuscript corrections.

C.1069: 'The X-ray analysis of the structure of Cephalosporin C', by Dorothy Crowfoot Hodgkin and E.N. Maslen, c.1961. Copy of a 16pp typescript draft with manuscript revisions by Abraham; referee's comments and response; data found with the article.

C.1070: 'Broadcast for Australia' by Howard Florey, c.1962-1964. Copy of a 9pp incomplete typescript draft of a script inscribed 'HWF' (Florey's initials) on the first page.

C.1071-C.1074: Typescript reports, with some manuscript notes, on experiments by D. Perry. Reports, etc., regarding work on isopenicillin N synthesase, 1983-1985.

C.1075-C.1082: Typescript reports, with some manuscript notes, on experiments by P.A. Whiteman (neé Fawcett). Reports regarding work on penicillin acylase, etc., 1984-1990.

Miscellaneous papers
Date: 1985-1986
Shelfmark: MS. Abraham 112/C.1083-C.1088
Language(s) of Material: English
Extent: 6 folders

Scope and Content

Typescript reports, with some manuscript notes, on experiments by M.S. Thorniley regarding work on E-coli and C. acremonium, etc.

Miscellaneous papers
Date: 1945-1985, 1991, n.d.
Shelfmark: MS. Abraham 113/C.1089-C.1096
Language(s) of Material: English
Extent: 8 folders

Scope and Content

Included are reports, manuscript notes, and experimental data.

Miscellaneous papers
Date: 1945-1985, 1991, n.d.
Shelfmark: MS. Abraham 114/C.1097-C.1100
Language(s) of Material: English
Extent: 4 folders

Scope and Content

Included are reports, manuscript notes, and experimental data.

Miscellaneous papers
Date: 1945-1985, 1991, n.d.
Shelfmark: MS. Abraham 115/C.1101-C.1108
Language(s) of Material: English
Extent: 8 folders

Scope and Content

Included are reports, manuscript notes, and experimental data.

Miscellaneous papers
Date: 1945-1985, 1991, n.d.
Shelfmark: MS. Abraham 116/C.1109-C.1114
Language(s) of Material: English
Extent: 6 folders

Scope and Content

Included are reports, manuscript notes, and experimental data. At C.1114 is a laboratory manual.

D   Publications 1939-1996, n.d.

D.1   Drafts 1939-1996, n.d.

Full range of shelfmarks:

MS. Abraham 117/D.1 - MS. Abraham 132/D.270

Draft articles and reviews
Date: 1955-1995
Shelfmark: MS. Abraham 117/D.1-D.22
Language(s) of Material: English
Extent: 22 folders

Scope and Content

D.1: 'Some Chemical and Biological Properties of New Antibiotics of the Penicillin Group', co-authored with G.G.F. Newton, Chemical Science and Industry USSR I, 1956. 40pp photocopy of a typescript, with manuscript corrections and additions; 1p manuscript notes by another.

D.2-D.3: 'The Antibiotics in Microbiology', Endeavour 18, October 1959. Correspondence regarding publication with corrected proofs of article.

D.4: Review: Recent Progress in Microbiology, edited by G. Tunevall, Oxford 1959. Correspondence regarding publication; 1p photocopy of the typescript draft of the review and a cutting of the printed version.

D.5: Review: 'Antibiotics in Medicine', British Medical Bulletin, 16, No.1, 1960. Letter with a 1p photocopy of the typescript of the review.

D.6: Correspondence regarding publication of an article 'New Penicillins, Cephalosporin C and Penicillinase', with G.G.F. Newton, Endeavour 20, 1961.

D.7: The Molecular Basis of Antibiotic Action, by E.F. Gale et al., Chichester 1972. Letters regarding a review request with a 1p photocopy of the printed version of the review.

D.8: Review: Fifty Years of Antimicrobials: Past Perspectives and Future Trends, edited by P.A. Hunter et al., The Society for General Microbiology, 1995. Correspondence regarding publication; 1p manuscript and 1p typescript drafts of the review, with a corrected version.

D.9: Correspondence regarding an unidentified article by Abraham about Cephalosporin C, February-December 1960. Also includes a letter requesting Abraham to review a book, 1955.

D.10: Correspondence with Endeavour regarding orders for binding cases, 1958-1968.

D.11: 'Antibiotics', Enciclopedia Medica Italiana, 1959 or later. Correspondence regarding publication, 1959; 26pp copy of a typescript draft (with bibliography), with manuscript corrections.

D.12: 'The Chemistry and Classification of Antibiotics', with Guy Newton, British Medical Bulletin 16, 1960. 20pp copy of a typescript draft (with tables and references), with manuscript corrections and additions.

D.13: 'Derivatives of Cephalosporin C formed with certain Heterocyclic Tertiary Bases', with C.W. Hale and G.G.F. Newton, Biochemical Journal 79, 1961. Includes a letter regarding preparation, 1960, a 15pp copy of the typescript draft (with references, etc.), with manuscript corrections, and 3 typescript pages of other drafts and figures, probably related to the article.

D.14 'New Penicillins, Cephalosporin C and Penicillinase', with G.G.F. Newton, Endeavour 20, 1961. 17pp copy of a typescript draft (with references and figures), with manuscript corrections and additions.

D.15-D16: 'The Cephalosporins: history and scientific background', Medical News 48, 1963. Includes correspondence regarding publication, a 7pp copy of a typescript draft, with manuscript revisions, etc., and a copy of the revised version with a figure. Also included is a copy of the published version of the article, with extensive manuscript revisions, and a copy of the revised version with figure, etc., n.d.

D.17: 'Production of a Cephalosporinase by Pseudomonas pyocyanea', with M.Jago and A. Migliacci, Nature 199, 1963. Includes a 4pp copy of the typescript draft with manuscript corrections, a proof with manuscript corrections, a reprint, and a copy of the typescript, with figures, describing experimental results, probably related to the article.

D.18: Review for Nature. Joint review article by Abraham covering a number of publications on antimicrobial agents and chemotherapy (mostly published in 1963), including Antimicrobial Agents and Chemotherapy - 1962. Proceedings of the Second Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Illinois, October 31-November 2 1962, American Society for Microbiology 1963. Includes correspondence regarding review requests, an 8pp photocopy of the review article, and a corrected proof.

D.19: Review for Nature. Antimicrobial Agents and Chemotherapy - 1963. Proceedings of the Third Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington DC, October 18-30 1963, American Society for Microbiology 1963. Includes correspondence regarding publication, a 3pp typescript draft of the review with manuscript corrections and copy of later typescript draft, and a corrected proof.

D.20: Review for Nature. Antimicrobial Agents and Chemotherapy - 1964. Proceeding's of the Fourth Interscience Conference on Antimicrobial Agents and Chemotherapy, New York, October 26-28 1964, American Society for Microbiology, ?1965. Includes a 4pp copy of the typescript draft of the review, proof, and a copy of the typescript probably relating to one of the reviews in D.18-D.20.

D.21: Obituary of Professor Donald Devereux Woods, British Medical Journal 2, 1964. A 2pp copy of the typescript obituary and a cutting from the off-print.

D.22: 'The Cephalosporin Story', New Scientist 24, No. 217, 1964. A 6pp copy of the typescript draft, with manuscript corrections and figures, and a letter regarding publication.

Draft articles and reviews
Date: 1964-1967
Shelfmark: MS. Abraham 118/D.23-D.32
Language(s) of Material: English
Extent: 10 folders

Scope and Content

D.23: 'The Chemistry of New Antibiotics', The American Journal of Medicine 39, 1965. 21pp copy of a typescript draft (including references and figures) with manuscript corrections, and a letter regarding publication.

D.24: Correspondence regarding an article which Abraham contributed to a 1963 volume dedicated to von Euler on the occasion of his 90th birthday (apparently later published in the Biochemical Journal), October-November 1962.

D.25-D.26: 'Enzymic Behaviour of the Cephalosporins', with L.D. Sabath, Enzymologia 29 (memorial volume to Professor H. von Euler), 1965. Correspondence regarding publication, with a 1p copy of the typescript 'summary' of the article and a copy of a typescript article for the 1963 volume (see D.24). 1965, 1966.

D.27: 'The Cephalosporins', with G.G.F. Newton, Advances in Chemotherapy 2, 1965. Proof with manuscript corrections and revisions, and correspondence regarding publication. See C.562 and C.563 for a draft of this paper.

D.28: Review for Nature (published in 1965): Advances in Drug Research, London 1964. Includes letters regarding publication, a 2pp copy of the typescript of the review, and a proof.

D.29-D.30: 'Experiments relating to the Biosynthesis of Bacilysin', with Joan Roscoe, Biochemical Journal 99, 1966. D.29 contains a 21pp copy of a typescript draft (with references and figures) with manuscript revisions. D.30 contains a later copy of a typescript draft with manuscript corrections.

D.31: Review for British Medical Journal: Biochemical Studies of Antimicrobial Drugs, Cambridge University Press 1966. Includes correspondence regarding publication and a 2pp copy of the typescript of the review, with manuscript corrections.

D.32: 'The Cephalosporin C Group', Chemical Society Quarterly Reviews 21, No. 2, 1967. Proof with manuscript corrections.

Howard Florey material
Date: 1968-1971
Shelfmark: MS. Abraham 119/D.33-D.57
Language(s) of Material: English
Extent: 25 folders

Scope and Content

D.33: Appreciation of Florey in an obituary notice by various writers, The Lancet, 2 March 1968. A letter of thanks, 1p of typescript message of appreciation, and an off-print.

D.34: Appreciation of Florey in an obituary notice by various writers, British Medical Journal, 2 March 1968. 1p copy of a typescript message of appreciation with manuscript corrections. photocopy of an off-print, and a letter of thanks.

D.35: Obituaries for Oxford Magazine, 31 May 1968, and ?[Lincoln College Magazine]. Abraham's obituary for ?[Lincoln College Magazine] was a revised version of the one he wrote for Oxford Magazine. Contains correspondence regarding obituary for Oxford Magazine, with corrected proof and a copy of a re-print with manuscript revisions and 2 copies of typescript drafts (8pp and 9pp) of obituary for ?[Lincoln College Magazine] with manuscript corrections.

D.36: 'Lord Florey', Chemistry in Britain 4, No. 9, May 1968. Letters regarding a 3pp typescript draft with manuscript corrections and a 2pp copy of a

D.37: 2pp manuscript draft, with revisions, of obituary, a copy of the typescript-corrected version, and an off-print. Publication unknown. ?1968.

D.38: 1p untitled typescript draft of obituary with manuscript corrections by Abraham and another, ?1968. Publication unknown.

D.39: Short account of Florey's life, Sunday Times Magazine, 1969. Correspondence regarding publication, May 1969 and a 1p copy of the typescript draft, with manuscript corrections.

D.40-D.89: 'Howard Walter Florey, Baron Florey of Adelaide and Marston 1898-1968', Biographical Memoirs of Fellows of the Royal Society 17, November 1971.

In March 1968 Abraham was asked to write the Royal Society Memoir for which he undertook a great deal of research into Florey's life in Australia and at Oxford. Despite having to negotiate some sensitive issues, he produced an article considered by most to be authoritative and very interesting.

D.40-D.57: Correspondence and papers regarding Abraham's preparation of the memoir, 1968-1971. Correspondents include individuals and organisations with access to documentary records, former colleagues of Florey and his family, and acquaintances.

Howard Florey: Biographical Memoirs of Fellows of the Royal Society
Date: 1939-1954, 1968-1974, n.d.
Shelfmark: MS. Abraham 120/D.58-D.76
Language(s) of Material: English
Extent: 19 folders

Scope and Content

D.58-D.64: Correspondence arising from publication of the memoir, mostly letters of thanks from fellow scientists in receipt of copies, with congratulations and comments, September 1971-1972, 1974.

D.65: Copy of an off-print of the memoir.

D.66-D.69: Correspondence between Florey and the Medical Research Council regarding grants and assistance provided by the latter for research on penicillin, 1939-1946.

D.70-D.71: Carbon copies of extracts of letters by Florey, Lady (Ethel) Florey and Norman Heatley to John F. Fulton and Lucia Fulton, 1940-1945.

D.72: Photocopies of letters by Florey to John F. Fulton, 1947-1954.

D.73: Photocopies of correspondence relating to Florey's fact-finding tour to Australia and New Zealand in 1944 to visit medical establishments, and a photocopy of his report of the tour, 1945.

D.74: Letters to Abraham from Florey, with related material, 1953-1968.

D.75: Miscellaneous correspondence of Florey, mostly photocopies, with related papers, 1945-1968.

D.76: Correspondence regarding Florey's life, 1957-1969.

Howard Florey material
Date: n.d.
Shelfmark: MS. Abraham 121/D.77-D.89
Language(s) of Material: English
Extent: 13 folders

Scope and Content

Miscellaneous printed and typescript material, manuscript notes by Abraham, and correspondence relating to Florey's life. Photographs in D.79.

Howard Florey material
Date: 1950-1996
Shelfmark: MS. Abraham 122/D.90-D.114
Language(s) of Material: English
Extent: 25 folders

Scope and Content

D.90-D.91: Article on Florey in A Biographical Dictionary of Scientists, London 1974. 8pp manuscript draft and 2 typescript drafts, all with manuscript revisions. Also includes correspondence regarding publication

D.92: Review for Nature 282, No. 5735 (Autumn Books Supplement, November 1979) entitled 'Florey's creative power' of the book Howard Florey: The Making of a Great Scientist, by Gwyn Macfarlane, Oxford University Press 1979. Includes correspondence regarding publication, an 11pp copy of of the typescript of the review, and a proof with manuscript corrections.

D.93: Revised notice for Florey in Dictionary of National Biography, 1986-1990, Oxford 1996. Copy of proof with manuscript revisions.

D.94-D.99: Other obituaries and articles on Florey written before his death, 1950-1968.

D.100: B.B.C. radio broadcast: 'Obituary on Lord Florey', by Abraham, recorded 1 March 1965. Correspondence regarding script, with contract, and a 2pp typescript draft script with manuscript corrections, inscribed 'Oxford studio'.

D.101: 'Portrait of Lord Florey', B.B.C. Radio Four, 28 March 1969. Abraham contributed an interview to the programme. The other speakers were Dr. C.M. Fletcher, Dr Sanders, John Prestwich, and Norman Heatley.

D.102: Correspondence regarding plans for a possible archival film featuring Florey, Abraham and/or Norman Heatley, 1966, 1967.

D.103: Miscellaneous correspondence with members of Florey's family regarding obituaries of Florey by Abraham, and other matters connected with his death, 1966-1969.

D.104-D.105: Miscellaneous correspondence and papers, mostly regarding publications (by individuals other than Abraham) and broadcasts on Florey and the history of penicillin, 1968-1989.

D.106-D.113: Correspondence and papers regarding fundraising for a memorial stone to Florey in Westminster Abbey (unveiled 2 November 1981) and preparations for the unveiling ceremony, with correspondence arising, 1980-1983. A few photographs are included.

D.114: Obituary of Mary Ethel Hayter Florey, Lady Florey, by Abraham, British Medical Journal, 1966 or 1967. 2pp copy of the typescript obituary and a letter regarding publication, October 1966.

Articles and papers
Date: 1969-1978, n.d.
Shelfmark: MS. Abraham 123/D.115-D.130
Language(s) of Material: English
Extent: 16 folders

Scope and Content

D.115-D.116: 'Behaviour of alpha-Aminoadipoyl and Glutamylcysteines in the Presence of Intact and Disrupted Mycelium of a Cephalosporium sp.', with P. Bronwen Loder and G.G.F. Newton, Biochemical Journal 112, 1969. This paper appears to have included another paper, 'Synthesis and Some Properties of alpha-Aminoadipoyl and Glutamy Cysteines', with P. Bronwen Loder, which was initially written separately.

D.117: 'Some Properties of Two Cell-bound Beta-Lactamases from Bacillus cereus 569/H', with S. Kuwabara, Biochemical Journal 115, 1969. 2 copies of typescript drafts with manuscript revisions, and correspondence regarding publication.

D.118: 'Biosynthesis of Peptides containing alpha-Aminoadipic Acid and Cysteine in Extracts of a Cephalosporium sp.', with P. Bronwen Loder, Biochemical Journal 123, 1971.

D.118A: 'Specificities of Haemagglutinating Antibodies Evoked by Members of the Cephalosporin C Family and Benzylpenicillin', with J.M.T. Hamilton-Miller, Biochemical Journal 123, 1971. Proof with manuscript corrections.

D.119: Review for an unknown publication: Yeast Mould and Plant Protoplasts, edited by J.R. Villanueva et al., New York 1973. 2pp typescript draft with manuscript corrections.

D.120: Draft paper with the draft title 'On the (role/involvement) of microbial penicillin- and cephalosporin- acylases and/in the biosynthesis (mechanism) of beta-Lactam antibiotics'. The authors were originally given as Abraham and E.J. Vandamme, though Abraham's name has been crossed out. Inscribed 'summer '73 Oxford Univ'. Copy of the 37pp manuscript (in a hand other than Abraham's) and a typescript draft, with manuscript revisions by Abraham.

D.121-D.123: Articles contributed by Abraham to Methods in Enzymology, Vol. 30, New York 1974: 'Acetyl Esterase, a Citrus Enzyme, with Patricia Fawcett, and 'δ-(α-Aminoadipyl)cysteinylvaline Synthetase', with Patricia Fawcett. Includes correspondence regarding publication.

D.124: 'Biosynthesis and Enzymic Hydrolysis of Penicillins and Cephalosporins', University of Tokyo Press 1974. Paper resulting from an E.R. Squibb Lecture. 35pp copy of the typescript with references and figures.

D.125: 'Synthesis of Tritium-labelled Isopenicillin N, Penicillin N and 6-Aminopenicillanic Acid', with J.J. Usher and P. Bronwen Loder, Biochemical Journal 151, 1975.

D.126: 'Behaviour of Tritium-labelled Isopenicillin N and 6-Aminopenicillanic Acid as Potential Penicillin Precursors in an Extract of Penicillium chrysogenum', with Patricia A. Fawcett and J.J. Usher, Biochemical Journal 153, 1975.

D.126A: 'Biosynthesis of Penicillins and Cephalosporins', with Patricia A. Fawcett, Biosynthesis IV: The Chemical Society Specialist Periodical Reports.

D.127: 'Synthesis of δ-(α-Aminoadipyl) cysteinylvaline and its Role in Penicillin Biosynthesis', with Patricia A. Fawcett, John J. Usher, Joyce A Huddleston, Roger C. Bleaney, and Judith J. Nesbitt, Biochemical Journal 157, 1976.

D.128: Review for The Times Literary Supplement entitled 'Bad news for bacteria', 17 December 1976: Penicillin in Perspective, by David Wilson, London 1976.

D.129: Review for The Times Literary Supplement entitled 'The Molecular Key', 12 August 1977: New Worlds in Chemistry, London 1976.

D.130: 'The Stereochemistry of B-Lactam Formation in Cephalosporin Biosynthesis', with Joyce A. Huddleston et al., Biochemical Journal 169, 1978.

Ernst Boris Chain material
Date: 1979-1983, n.d.
Shelfmark: MS. Abraham 124/D.131-D.141
Language(s) of Material: English
Extent: 11 folders

Scope and Content

D.131: Chain obituary for the Biochemical Society Bulletin, Vol.1, no.5, 1979.

D.132: Correspondence regarding Chain obituary by Abraham for The International Journal of Environmental Studies, September-October 1979.

D.133: 2 copies of typescript Chain obituaries, probably by Abraham, one with annotations by him, for unknown publications.

D.134: Article on Chain in A Biographical Dictionary of Scientists, London 1982.

D.135-C.141: Ernst Boris Chain', Biographical Memoirs of Fellows of the Royal Society, 29, 1983. Correspondence, etc., regarding preparation and drafting of the memoir, 1979-July 1983.

Ernst Boris Chain material
Date: 1979?-1988
Shelfmark: MS. Abraham 125/D.142-D.163
Language(s) of Material: English
Extent: 22 folders

Scope and Content

D.142-D.145: Extensive and detailed manuscript notes on Chain's life and career extracted from cited correspondence and other documentary sources.

D.146-D.148: Early manuscript draft of 'Ernst Boris Chain', apparently incomplete, with extensive revisions, (paginated 1-98, with gaps).

D.149-D.152: Typescript draft of 'Ernst Boris Chain' inscribed '1st Draft', with manuscript revisions.

D.153-D.158: Copy of a later typescript draft of 'Ernst Boris Chain', with bibliography etc.; probably the draft circulated to various individuals for comment.

D.159: A few typescript and manuscript pages from a draft (or drafts), different to those described in D.146-D.158, drafts of figures' and a few miscellaneous manuscript notes.

D.160: Offprint of the Memoir.

D.161-D.163: Correspondence arising from the publication of the Memoir, mostly letters of thanks from members of the scientific community and friends in receipt of a copy, with congratulations and comments, 1983, 1984, and with a few letters 1985-1988.

Ernst Boris Chain material
Date: 1969-1979
Shelfmark: MS. Abraham 126/D.164-D.177
Language(s) of Material: English
Extent: 14 folders

Scope and Content

D.164: Correspondence between Abraham and Chain mostly in connection with the former's preparation of the Royal Society Biographical Memoir of Florey, 1969.

D.165: Copies of Chain correspondence, 1969-1976. Letters by Chain to Sir Bernard Katz in which Chain complains of lack of recognition in Britain, 1969. Correspondence with Government ministers and leading scientists regarding issues in biochemical and general scientific research, 1971-1976. Correspondence with Sir Robert Robinson, mostly regarding the history of penicillin, March-May 1974.

D.166: Correspondence, mostly between Abraham and Sir Robert Robinson, concerning claims made by Chain about his role in the development of penicillin, April 1974-January 1975; 2 unrelated letters by Abraham and Chain (copy), 1969, 1979.

D.167-D.170: Miscellaneous typescript and printed material (some photocopies) and manuscript notes by Abraham relating to Chain's career and the development of penicillin.

D.171: Stock obituary of Chain for The Times.

D.172-D.177: 'Biologically Active Substances - exploration and exploitation', a symposium to mark Chain's 70th birthday held at the Royal Society, 15-16 June 1976. Correspondence regarding arrangements, with programme and a few letters arising, 1975, 1976. 'The Biosynthesis of B-lactam Antibiotics', Abraham's paper. 14pp manuscript draft with revisions, 2 typescript drafts, one incomplete, with manuscript revisions, and a copy of a 2pp typescript outline. Correspondence regarding publication of Abraham's paper in Biologically Active Substances - Exploration and Exploitation, edited by D.A. Hems, Wiley 1977.

Restrictions on Access:

Folder D.165 closed.


Articles and papers
Date: 1978-1981, n.d.
Shelfmark: MS. Abraham 127/D.178-D.196
Language(s) of Material: English
Extent: 19 folders

Scope and Content

D.178: 'Transport and Metabolism of Bacilysin and Other Peptides by Suspensions of Staphylococcus aureus', with David Perry, Journal of General Microbiology 115, 1979. Proof with manuscript corrections.

D.179: 'Incorporation of 3H from δ-(L-α-Amino[4,5-3H]adipyl-L-cysteinyl-D-[4,4-3H]valine into Isopenicillin N', with Joseph O'Sullivan, Roger C. Bleaney, and Joyce A. Hudleston, Biochemical Journal 184, 1979.

D.180: Review for Endeavour, ?1979: 'Antibiotics: isolation, separation and purification', Journal of Chromatography Library Vol. 15, edited by M.J. Weinstein and G.H. Wagman, ?1978.

D.181: 'A Spectroscopic Study of Metal Ion and Ligand Binding to B-Lactamase II', with Graham S. Baldwin, Alphonse Galdes, H. Allen O. Hill, and Stephen G. Waley, Journal of Inorganic Biochemistry 13, no.3, 1980.

D.182: 'Penicillin Biosynthesis: Conversion of Deuterated δ-(L-α-Aminoadipyl) - L - Cysteinyl - D - Valine to Isopenicillin N by a Cell-free Extract of Cephalosporium acremonium', with Jack E. Baldwin et al., Chemical Communications, 1981.

D.183-D.189: 'The B-Lactam Antibiotics', Scientific American 244, No.6, 1981.

D.190: 'Conversion of Isopenicillin N into Penicillin N in Cell-free Extracts of Cephalosporium acremonium', with G.S. Jayatilake and J.A. Huddleston, Biochemical Journal 194 (part 2), 1981.

D.191-D.195: 'Biosynthesis of B-Lactam Antibiotics', with J. O'Sullivan, in Antibiotics IV: 'Biosynthesis', ed. by J.W. Corcoran, Berlin 1981.

D.196: 'Biosynthesis of Penicillins and Cephalosporins in Cell-free Systems', with J. O'Sullivan and J.A. Huddleston, for Philosophical Transactions of the Royal Society, ?1980.

Articles and papers
Date: 1978-1984
Shelfmark: MS. Abraham 128/D.197-D.213
Language(s) of Material: English
Extent: 17 folders

Scope and Content

D.197-D.208: 'Isolation and Properties of an Inducible and a Constitutive B-Lactamase from Pseudomonas aeruginosa', with M. Berks and K. Redhead, Journal of General Microbiology, 1982.

D.209: 'Inhibition of Glucosamine Synthetase by Bacilysin and Anticapsin', by Henryk Chmara, Journal of General Microbiology, ?1984. The paper was revised by Abraham prior to publication.

D.210: 'Stoichiometry of Oxygen Consumption in the Biosynthesis of Isopenicllin N from a Tripeptide', with Robert L. White et al., Biochemical Journal 203, 1982.

D.211: 'Penicillin Biosynthesis: Oxygen Stoichiometry of Isopenicillin N Synthesis in a Cell-free System', with Robert L. White et al., on which is inscribed the same publication reference as for the paper described in D.210. The texts of the articles are different; the authors are the same.

D.212: 'Penicillin Biosynthesis. Dual Pathways from a Modified Substrate', with Robert M. Adlington et al., Journal of Chemical Studies: 'Chemical Communications', 1983.

D.213: 'Conversion of 17O/18O Labelled δ-(L-α-Aminoadipyl)-L-cysteinyl-D-valine to 17O/18O Labelled Isopenicillin N in a Cell-free Extract of Cephalosporium acremonium', with Robert M. Adlington et al., Tetrahedron 39, 1983.

Articles, papers, and reviews
Date: 1979-1991
Shelfmark: MS. Abraham 129/D.214-D.234
Language(s) of Material: English
Extent: 21 folders

Scope and Content

D.214-D.215: 'Stereochemistry of the Incorporation of the Methyl Groups of 'Chiral Methyl Valine' into Methylene Groups in Cephalosporin C', with Chi-Pui Pang et al., Journal of Chemical Studies: 'Chemical Communications', 1983.

D.216-D.220: 'History of B-Lactam Antibiotics', a chapter in Handbook of Experimental Pharmacology, Vol. 67/1: Antibiotics Containing the Beta-Lactam Structure, Part 1, edited by A.L. Demain and N.A. Solomon, Berlin 1983.

D.221-D.222: 'Purification of Isopenicillin N Synthetase', with C.P. Pang et al., Biochemical Journal 222, 1984.

D.223: 'Stereochemistry of the Incorporation of Valine Methyl Groups into Methylene Groups in Cephalosporin C', Chi-Pui Pang et al., Biochemical Journal 222, 1984.

D.224: Review article entitled 'Benefactors' Benefactor' for The Times Literary Supplement, 27 January 1984: The Legacy of Alfred Nobel: The Story Behind the Nobel Prizes, by Ragnar Sohlman, London 1983.

D.225-D.226: Review entitled 'The Shooter and the Shot': Alexander Fleming: The Man and the Myth, by Gwyn Macfarlane, London 1984. The review was published in a special supplement by Nature, 'Spring Books', April 1984.

D.227: Review for FEBS Letters, ?May 1984: 'The Target of Penicillin. The Murein Sacculus of Bacterial Cell Walls'. Architecture and Growth, edited by R. Hakenbeck et al., Berlin 1983.

D.228-D.230: Notice for Ernst Chain in Dictionary of National Biography 1971-1980, Oxford 1986.

D.231-D.232: Notice for Sir Harry Jephcott in Dictionary of National Biography 1971-1980, Oxford 1986.

D.233: Correspondence regarding a proposed book on penicillin by Abraham, 1979, 1980. No definite plans for the book emerge from this correspondence.

D.234: Miscellaneous correspondence, etc., 1985-1991. This correspondence relates to Abraham's advisory role in various publications, including the History of the University of Oxford, Oxford 1992.

Papers, etc.
Date: 1984-1990
Shelfmark: MS. Abraham 130/D.235-D.246
Language(s) of Material: English
Extent: 12 folders

Scope and Content

D.235-D.240: Chapter for a proposed book The Cephalosporin Antibiotics. The title of Abraham's chapter was 'Cephalosporins 1945-1985'. The publishers, Adis Press Ltd. (New Zealand), eventually abandoned publication of the book. The material was published instead in a special supplement to Adis Press's international supplement Drugs, 1987.

D.241: 'Purification and Initial Characterization of an Enzyme with Deacetoxycephalosporin C Synthetase and Hydroxylase Activities', with Jack E. Baldwin et al., Biochemical Journal 245, 1987.

D.242-D.245: 'Factors Affecting the Isopenicillin N Synthetase Reaction', with D. Perry and J.E. Baldwin, Biochemical Journal 255, 1988.

D.246: 'Acyl Coenzyme A: 6-aminopenicillinanic Acid Acyltransferase from Penicillium chrysogenum and Aspergillus nidulans, with P.A Whiteman et al., FEBS Letters 262, 1990.

Papers, etc.
Date: 1990, n.d.
Shelfmark: MS. Abraham 131/D.247-D.258
Language(s) of Material: English
Extent: 12 folders

Scope and Content

D.247-D.250: 'Selective Reminiscences of B-Lactam Antibiotics. Early Research on Penicillin and Cephalosporins', for 'Roots' column, BioEssays: Advances in Molecular, Cellular and Developmental Biology, Vol. 12, No. 12, December 1990. (The 'Roots' column presented first-hand accounts of key discoveries or breakthroughs in the biological sciences.) Correspondence, drafts, etc.

D.251-D.252: Review for Nature: Miracle Cure. The Story of Antibiotics, by Milton Wainwright, Blackwell, 1990. Correspondence, drafts, etc.

D.253: 'Possible Intermediates in the Biosynthesis of Cephalosporin', with G.G.F. Newton. Copy of an 11pp typescript draft so entitled, with manuscript corrections.

D.254: 'The Cephalosporins'. Copy of an 8pp typescript draft with manuscript revisions.

D.255: 'Enzymes Involved in the Biosynthesis of Cephalosporin C'. Copy of a 7pp typescript draft, so entitled, with manuscript corrections.

D.256: 'Biosynthesis of Penicillins and Cephalosporins', with G.G.F. Newton. Copy of a 40pp typescript draft, with manuscript corrections, and index of subjects.

D.257-D.258: 'B-Lactamases and their Rôle in Resistance to B-Lactam Antibiotics'. 58pp copy of a typescript draft so entitled, with figures.

Papers, etc.
Date: n.d.
Shelfmark: MS. Abraham 132/D.259-D.270
Language(s) of Material: English
Extent: 12 folders

Scope and Content

D.259-D.265: Untitled manuscript and typescript draft of a book on antibiotics, with extensive manuscript revisions. The draft is divided into sections or chapters on particular antibiotics.

D.266-D.270: Miscellaneous material relating to unidentified publications, or possible publications, by Abraham. The material mostly consists of parts of manuscript and typescript drafts and notes.

D.2   Editorial correspondence 1949-1988

Scope and Content

Correspondence and papers regarding refereeing of papers intended for publication, general editorial business, and publications by Abraham. Shorter correspondence is at MS. Abraham 133/D.284-D.288.

Full range of shelfmarks:

MS. Abraham 133/D.271-D.288

Editorial correspondence
Date: 1949-1988
Shelfmark: MS. Abraham 133/D.271-D.288
Language(s) of Material: English
Extent: 18 folders

Scope and Content

D.271-D.274: The Biochemical Journal. Abraham served on the Editorial Board, c.1955-1960. Included is correspondence re publication of papers by Abraham in the Journal found with the editorial correspondence.

D.275-D.276: Elsevier Publishing Company, 1960-1964. Correspondence, including re-prints, mostly with Elsevier Publishing Company, regarding Comprehensive Biochemistry, edited by Marcel Forkin and Elmer H. Stotz, Elsevier 1962. Abraham wrote a chapter for Volume 2.

D.277-D.281: The Journal of Antibiotics, 1988-1998. Abraham was an Emeritus Member. The papers are mostly regarding the business of the Editorial Board.

D.282: Pharmacological Reviews, 1960-1962. Correspondence mainly regarding a review by Abraham of a book The Cephalosporins for Pharmacological Reviews 14, 1962.

D.283: Sherry F. Queener, 1983-1987. Correspondence, etc., mostly with Sherry F. Queener regarding Beta-Lactam Antibiotics for Clinical Use, edited by Queener et al., New York 1986. Abraham contributed a chapter to the book.

D.284-D.288: Shorter correspondence, 1948-1998. Arranged chronologically.

E   Lectures and broadcasts 1942-1993, n.d.

E.1   Lectures associated with teaching 1942-1973, n.d.

Full range of shelfmarks:

MS. Abraham 134/E.1 - MS. Abraham 136/E.22

Lecture notes and handouts on pathology
Date: 1942-1971, n.d.
Shelfmark: MS. Abraham 134/E.1-E.8
Language(s) of Material: English
Extent: 8 folders

Scope and Content

E.1-E.2: Copies of lecture or course handouts for students, 1942-1951, n.d.

E.3-E.5: Manuscript and typescript notes and drafts for various lectures, c.1957-c.1971, n.d. Most sets of notes have titles. At E.3 are a page inscribed '1957' and three sets of notes which appear to relate to a card containing a list of lecture titles dated 1962. A few photographs are included at E.4.

E.6: Letters (invitations and acceptance) regarding proposed lectures by Abraham in early 1970 and early 1971.

E.7: Typescript entitled 'Haemostasis and Thrombosis', inscribed 'Pathology 1971 New Class Sheets'.

E.8: Offprints of various lectures and papers by Abraham, 1958-1966, n.d.

'Lectures on General Pathology'
Date: n.d.
Shelfmark: MS. Abraham 135/E.9-E.20
Language(s) of Material: English
Extent: 12 folders

Scope and Content

Copies of typescripts of lectures, most, or all, by Abraham, many with manuscript revisions. A number of the lecture titles correspond to those of some pages of notes and drafts in E.3-E.5. Some of the texts include inserted pages of manuscript notes.

Most of the material shows continuous pagination (with gaps) and division into chapters, indicating that many or all the lectures formed part of a publication.

Lecture notes and arrangements
Date: 1970-1973, n.d.
Shelfmark: MS. Abraham 136/E.21-E.22
Language(s) of Material: English
Extent: 2 folders

Scope and Content

E.21: Hardback notebook containing notes for various lectures, n.d. Inscribed 'E.P Abraham Sir William Dunn School of Pathology Oxford' on the inside cover.

E.22: Correspondence regarding arrangements for 3 University of Bath seminars, 1970-1973.

E.2   Public lectures and broadcasts 1960-1993, n.d.

Full range of shelfmarks:

MS. Abraham 137/E.23 - MS. Abraham 138/E.63

Public lectures and related correspondence
Date: 1960-1993, n.d.
Shelfmark: MS. Abraham 137/E.23-E.45
Language(s) of Material: English
Extent: 23 folders

Scope and Content

E.23-E.25: 'ONR' Lecture (banquet speech) by Abraham at the Annual Meeting of the Society for Industrial Microbiology, Northwestern University, Evanston, Illinois, USA, 19-24 August 1973. The title of the speech was 'Some Aspects of the Development of the Penicillins and Cephalosporins'. E.23 contains correspondence regarding arrangements and arising, May-February 1974. E.24 contains a 29pp typescript draft of the lecture with manuscript revisions and a 22pp copy of the typescript of the lecture. The lecture was published in Developments in Industrial Microbiology, Volume 15. E.25 contains a copy of the Society of Industrial Microbiology Newsletter, July 1973, containing the programme etc., for the Annual Meeting in 1973 and a short biography of Abraham.

E.26-E.28: Lecture by Abraham given at the Technische Universität Berlin, Germany, 4 June 1982. The lecture was within the framework of the University's research branch 'Structure, Function and Biosynthesis of Peptides and Proteins'. E.26 contains correspondence, etc., regarding arrangements and arising, March-June 1982. E.27 an 18pp typescript draft of the lecture, with manuscript corrections, headed 'Berlin' and 2pp of typescript and manuscript notes. E.28 contains other correspondence arising from Abraham's association with the Technische Universität, January-November 1982.

E.29-E.30: Squibb lecture, University of Nottingham, 12 May 1983. E.29 contains correspondence regarding arrangements and arising, July 1982-May 1983. E.30 contains a 2pp incomplete manuscript draft of Abraham's lecture 'The Cephalosporins - origins and future'.

E.31-E.33: Lecture by Abraham given at the Technische Universität Berlin, Germany, 24 June 1983. The lecture was in the framework of the University's research branch 'Structure, Function and Biosynthesis of Peptides and Proteins' E.31 contains correspondence, etc., regarding arrangements and arising, March-November 1983. E.32 contains a 20pp typescript draft with manuscript revisions, a 15pp typescript revised version with manuscript annotations, and a 1p manuscript list of slides. E.33 contains 19pp manuscript notes with copies of figures, probably related to the drafts described in E.32.

E.34: Correspondence regarding invitation and arrangements, February-July 1991, for a lecture given to the Southampton Medical Society, (arranged for) 2 October 1991. The lecture was on the origins and developments of penicillins and cephalosporins.

E.35-E.36: Lecture given at the National Portrait Gallery: 'Alexander Fleming and his Remarkable Discoveries', 31 March 1993. E.35 contains correspondence regarding arrangements and arising, October 1992-April 1993. Also included is correspondence regarding a proposed Fleming Museum in St Mary's Hospital, October 1992-February 1993. E.36 contains a 12pp incomplete manuscript draft with revisions, an incomplete typescript draft with manuscript revisions, and a revised typescript draft with prints and photocopied material used as slides.

E.37: Includes a 20pp typescript draft, with manuscript revisions, entitled 'Mode of Action of Antibiotics', a 9pp typescript draft, with manuscript revisions, headed 'Canberra', a 19pp copy of a typescript entitled 'The Impact of Antibiotics on Medicine, and a revised version of the latter, probably for publication. From a file inscribed Lectures - Australia'. The lectures were probably given at the International Symposium on the Chemistry of Natural Products, Australia, 15-25 August 1960.

E.38: 'Some Aspects of Resistance to Antibiotics', given at a seminar on infectious disease organised by the Oxford Regional Committee for Postgraduate Medical Education and Training, 16 February 1971. Includes correspondence regarding arrangements, August-November 1970, 6pp manuscript notes for thelecture, 17pp typescript draft of lecture, with manuscript revisions, and 4 typescript pages (probably used for slides).

E.39: 3pp incomplete typescript draft, with manuscript revisions, headed 'Orthopaedic Centre March 1st 1975' and 3pp manuscript notes for the remainder of the lecture.

E.40: 'Beta-Lactam Antibiotics: A Brief Modern History', a lecture given at the 9th International Congress of Chemotherapy, Royal Albert Hall, London, 13-19 July 1975. Includes 12pp copy of typescript of the lecture, the programme, etc.

E.41: 25pp typescript of a lecture entitled 'The Cephalosporins', inscribed 'History of Science April 1976', with a 1p manuscript list of slides, and 3pp typescript notes for the lecture with manuscript annotations.

E.42: 21pp copy of typescript of a lecture entitled 'Cephalosporin', inscribed '50th Anniversary April 1977', with 2pp typescript of a speech introducing Abraham.

E.43: 7pp typescript draft with manuscript revisions entitled 'Some British Contributions to Antibiotics and Progress in Chemotherapy', n.d.

E.44: Miscellaneous manuscript and typescript notes and lists of slides etc., with 2 photographs, for unidentified lectures, n.d.

E.45: Miscellaneous correspondence, mostly regarding arrangements and arising, relating to various lectures, 1960-1985; typescript of an article entitled 'The Penicillin Nucleus' and inscribed '14 March 1959', with a letter regarding its publication in the British Medical Journal, 1959.

Undated lectures and broadcasts
Date: 1962-1991, n.d.
Shelfmark: MS. Abraham 138/E.46-E.63
Language(s) of Material: English
Extent: 18 folders

Scope and Content

E.46: Contents of a file entitled 'Lectures - Biochemistry'. Includes Manuscript notes for 2 lectures entitled 'Sequence of Amino Acids in Proteins' and 'Hypertension', n.d.

E.47: 'The Chemistry of the Penicillins'. 24pp copy of typescript with manuscript diagrams, n.d.

E.48-E.51: Contents of a file inscribed 'Ceph-Pen structures photographs, n.d. E.48 contains an incomplete, untitled 11pp manuscript draft with 4pp manuscript diagrams and notes, and an incomplete, untitled 8pp manuscript draft.E.49-E.51 contain figures for slides, etc., (mostly photographs).

E.52: Invitations declined, 1988, 1991.

E.53: BBC interview (Abraham and Guy Newton) on the subject of Cephalosporin for a television programme. Includes Correspondence re arrangements and arising, November 1962-January 1963.

E.54: 4pp copy of a transcription (probably incomplete) of a monologue by Abraham on Howard Florey and the development of penicillin from a BBC radio programme, 17 December 1968.

E.55: Correspondence regarding Abraham's assistance in research for a BBC Open University chemistry programme, June 1977.

E.56: 'Antibiotics - a Failing Weapon?', BBC World Service, 21 September 1977. Abraham spoke about Brötzu's discovery of cephalosporium. 10pp typescript of the programme script and a copy of the contract.

E.57: Correspondence regarding a proposed BBC radio programme on the discovery of penicillin. October 1979.

E.58: 'Breakthrough' No. 4: Howard Florey, broadcast in 1983. A film in a documentary series on great medical figures. Abraham made a brief (non-speaking) appearance in the film and assisted in checking the script and in filming at the Sir William Dunn School of Pathology. Brief correspondence regarding preparation and a draft script with manuscript revisions and annotations by Abraham, August-December 1982.

E.59: Horizon TV documentary about penicillin: 'The Mould, the Myth and the Microbe', 27 January 1986.

E.60: Letters in connection with an interview Abraham gave to Radio Oxford, n.d.

E.61-E.62: 'The Cephalosporins', an educational film apparently made by E.R. Squibb & Sons Ltd. to increase understanding of the cephalosporin group of antibiotics.Abraham assisted in the making of the film and contributed a historical introduction to it. E.61 contains correspondence regarding preparations and arising, with 2 typescript draft scripts of Abraham's introduction and amended version, November 1974-January 1975.

E.63: Brief correspondence regarding arrangements for an interview which Abraham agreed to give to Fulcrum Productions Ltd., April-May 1991.

F   Visits and conferences 1955-1995

Full range of shelfmarks:

MS. Abraham 139/F.1 - MS. Abraham 145/F.88


Visits and conferences
Date: 1955-1967
Shelfmark: MS. Abraham 139/F.1-F.10
Language(s) of Material: English
Extent: 10 folders

Scope and Content

F.1: 3ème Congrès International de Biochimie, Brussels, Belgium, 1-6 August 1955. Abraham, with I.M. Lockhart, gave a lecture 'Hydrogenolysis of bacitracin' and, with Guy Newton, 'Antibacterial peptides related to penicillin. Copy of printed 'Résumés des Communications' (abstracts of the lectures

F.2: International Symposium on the Chemistry of Natural Products, Melbourne, Canberra and Sydney, Australia, 15-25 August 1960. The symposium was organised by the Australian Academy of Science and held under the auspices of the International Union of Pure and Applied Chemistry (IUPAC). Abraham, with Guy Newton, gave a lecture 'Degradation of cephalosporin C'. Includes a copy of the Symposium Handbook interleaved with pages of rough manuscript notes, some in Abraham's hand.

F.3: Conference (Gordon research Conference) on Medicinal Chemistry, Colby Junior College, New London, New Hampshire, USA, 30 July-3 August 1962. Abraham gave a lecture 'Biochemical and Microbiological Studies on Derivatives of 7-Amino-cephalosporanic Acid'. Includes a Programme with manuscript notes by Abraham on a number of pages and a letter arising, July 1962.

F.4: Cephaloridine Conference, New College Oxford, 13-16 March 1967. The conference was arranged jointly by the Fellowship of Postgraduate Medicine and Glaxo Laboratories Ltd. Abraham chaired one session for which he gave a short introductory speech. Contains a letter regarding arrangements, with programmes; a 1p copy of typescript of Abraham's speech entitled 'Cephaloridine - Historical Remarks'; and a 1p copy of a typescript of Guy Newton's speech from the same session.

F.5-F.10: Visit to the USA, April 1967. Abraham was invited to give lectures at the University of Wisconsin (one of a series of Rennebohm Lectures) and at a 'Penicillins and Cephalosporins' symposium held during the annual meeting of the American Academy of Pharmaceutical Sciences in Las Vegas. F.5-F.6 contain material relating to the Rennebohm Lecture by Abraham, University of Wisconsin, 6 April 1967. The title of the lecture was 'Penicillins and Cephalosporins - their chemistry in relation to biological activity'. F.7-F.8 contain material relating to the 'Penicillins and Cephalosporins' symposium, Las Vegas, 9-14 April 1967. The title of Abraham's lecture was 'Penicillins and Cephalosporins - their chemistry in relation to biological properties'. F.9 contains correspondence arising from the two lectures and from the visit to the USA in general, November 1966-September 1967. F.10 contains miscellaneous material found with the papers described above.

Visits and conferences
Date: 1967-1975
Shelfmark: MS. Abraham 140/F.11-F.25
Language(s) of Material: English
Extent: 15 folders

Scope and Content

F.11-F.15: 5th International Congress of Chemotherapy, Vienna, 26 June-1 July 1967. Abraham delivered a lecture 'Synthesis and Semisynthesis of Some Antibiotics'. Includes correspondence regarding arrangements and arising, a 16pp manuscript draft of the lecture, with corrections, and a 13pp corrected typescript version with manuscript annotations.

F.16-F.21: Visit to the USA, October 1967.Abraham delivered lectures at the annual meeting of the Infectious Diseases Society of America and at the Seventh Interscience Conference on Antimicrobial Agents and Chemotherapy, both in Chicago. A provisional title for Abraham's lecture at the Infectious Diseases Society of America is given as 'Penicillinases and Cephalosporinases'. At the Interscience Conference on Antimicrobial Agents and Chemotherapy, Abraham, with Guy Newton and S. Kuwabara, lectured on 'Preliminary observations on the formation and spontaneous breakdown of Cephalosporoic acids and their derivatives'. Includes correspondence regarding arrangements and arising and a printed booklet of abstracts of the papers presented at the conference.

F.22-F.25: Gregynog Natural Products Symposia, 1969-1975. The purpose of the symposia, held in Gregynog Hall, Wales, was to facilitate communication between research workers in industry and academic institutions. In 1971 the event was re-named 'European Symposium on Bio-Organic Chemistry'. Abraham participated in the 1973 and 1975 symposia. F.22-F.23: Abraham agreed to participate in the 1970 Symposium and partly prepared a lecture, but found he was unable to attend due to a mix-up in his diary. Includes a 35pp typescript draft of Abraham's intended lecture, 'Biosynthesis of Some Peptide Antibiotics'. F.24-F.25: European Symposium on Bio-Organic Chemistry Chemistry', 18-21 May 1973 and 16-19 May 1975. Includes correspondence regarding arrangements and arising, with programme etc.

Visits and conferences
Date: 1969-1975
Shelfmark: MS. Abraham 141/F.26-F.37
Language(s) of Material: English
Extent: 12 folders

Scope and Content

F.26-F.31: 8th Italian National Congress of Chemotherapy held by the Società Italiana di Chemioterapia (Italian Society of Chemotherapy), Sardinia, 8-[?9 or 10] May 1970. Abraham was invited to give the opening lecture in a session on cephalosporins. Includes correspondence regarding arrangements and arising, a 12pp typescript draft of the lecture 'Reflections on the Development of the Cephalosporins', with corrections and revisions, a copy of the typescript of the lecture in Italian, a copy of the typescript of edited version with related photographs of chemical structures, and a copy of the galley proof with enclosing letter to Abraham.

F.32: Symposium on Antibiotics, Quebec, Canada, 1-3 March 1971. Organised by The Medicinal Chemistry Division of the Chemical Institute of Canada. Programme listing Abraham as a lecturer on 'Penicillins and Cephalosporins'.

F.33-F.36: FEBS Special Meeting on Industrial Aspects of Biochemistry, Dublin, Ireland, 15-19 April 1973. Abraham delivered a lecture at the symposium on 'Biological Syntheses'. Includes correspondence regarding arrangements and arising, 2pp copy of the typescript abstract of the lecture, an 11pp incomplete typescript draft of the lecture, with manuscript corrections, and a 20pp typescript draft, with manuscript corrections and revisions, entitled 'Penicillins, Cephalosporins and the Biosynthesis of Peptide Antibiotics by Fungi', by Abraham and Patricia Fawcett.

F.37: Penicillinase Workshop, University of Newcastle upon Tyne, 16-18 April 1975. Abraham introduced and chaired a panel discussion. Includes correspondence regrading arrangements, with programme.

Visits and conferences
Date: 1977-1991
Shelfmark: MS. Abraham 142/F.38-F.53A
Language(s) of Material: English
Extent: 17 folders

Scope and Content

F.38-F.41: 5th FEMS Symposium, Basel, Switzerland, 14-16 September 1977. Abraham gave a lecture on 'Developments in the Chemistry and Biochemistry of Beta-lactam Antibiotics'. Includes correspondence regarding arrangements and arising, a 28pp copy of the typescript of the lecture with manuscript corrections and revisions, and correspondence regarding publication of the lecture with corrected proof.

F.42: 'Future Prospects and Past Problems in Antimicrobial Therapy: the Role of Cefoxitin', Harvard Club of Boston, USA, 24 and 25 May 1978. Contains programme listing Abraham as an invited speaker.

F.43-F.44: Table Rondes Roussel Uclaf: 'Mode of Action of Beta-Lactams', Paris, 6 and 7 December 1979. Abraham participated as a moderator. Includes correspondence regarding arrangements, with list of participants, and correspondence with individuals at Division Scientifique Roussel Uclaf and Roussel Laboratories regarding various matters.

F.45-F.47: International Symposium on B-lactam Antibiotics: 'Mode of Action, New Developments and Future Prospects', New York University Post-Graduate Medical School, 29 September-2 October 1980. Abraham gave a lecture entitled 'Discovery, Chemistry and Antibacterial Properties of Cephalosporins'. Includes correspondence regarding arrangements, 1p of manuscript notes for the lecture, a 13pp typescript of the lecture with manuscript revisions, and a 15pp copy of typescript of the published? version of the lecture.

F.48-F.51: 'Launching the Antibiotic Era: Personal Accounts of the Discovery and Use of the First Antibiotics', a symposium held at the Rockefeller University, New York, on 23 October 1989. The symposium was held to celebrate the 50th anniversary of the discovery of Gramicidin by René Dubos. Abraham gave a lecture entitled 'Oxford, Howard Florey and World War II'. Abraham's lecture and the contributions by other speakers appeared in a subsequent Rockefeller University Press publication Launching the Antibiotic Era, New York 1990. Includes correspondence regarding arrangements and publication, 1p of manuscript notes for the lecture, a 12pp typescript draft of the lecture with manuscript corrections, 15pp typescript of the expanded version, and an off-print of the published lecture.

F.52-F.53: 21st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, USA, 4-6 November 1981. The subject of the conference was biosynthesis of B-lactam antibiotics. Abraham gave a lecture probably entitled 'Enzymes Involved in the Biosynthesis of Cephalosporin C'. Includes correspondence regarding arrangements and arising, a 7pp typescript of the lecture with manuscript corrections, and an 8pp typescript of the same with extensive manuscript revisions (probably for publication).

F.53A: First ASEAN Workshop on 'Fermentation Technology applied to the utilization of food waste materials', Kuala Lumpur 22-24 February 1982. Contains typescript copies of 2 lectures given by Abraham entitled 'B-lactam Antibiotics - an Outline' and 'Biosynthesis of B-lactam Antibiotics - an Outline.

Visits and conferences
Date: 1983-1985
Shelfmark: MS. Abraham 143/F.54-F.67
Language(s) of Material: English
Extent: 14 folders

Scope and Content

F.54-F.57: 13th International Congress of Chemotherapy, Vienna, 28 August-2 September 1983. At the conference Abraham was presented with the Hamao Umezawa Award for Chemotherapy by the International Society of Chemotherapy and gave an Award Lecture entitled 'Aspects of the Biosynthesis of B-Lactam Antibiotics'. Includes correspondence regarding arrangements, a 6pp copy of the typescript of the Award Lecture, with brief manuscript annotations, and a few manuscript and typescript notes, and a 14pp manuscript draft, with revisions, of an unidentified lecture (on the biosynthesis of B-lactam antibiotics) headed 'Vienna'.

F.58-F.59: Meeting organised by E.R. Squibb & Sons Inc.: 'Therapeutics for a Changing World', Princeton University, 27 September 1983. Held to commemorate the 125th Anniversary of the founding of E.R. Squibb & Sons Inc. Includes correspondence regarding arrangements and a 9pp untitled manuscript draft of the lecture with revisions.

F.60-F.61: 607th Meeting of the Biochemical Society, Polytechnic of Central London, 19-21 December 1983. Abraham gave a lecture at a colloquium on 'Advances in the Biochemistry and Genetics of Antibiotic Producing Organisms'. Includes correspondence regarding arrangementsand publication of the lecture, a typescript summary of the lecture, and an 8pp copy of the published version of the lecture entitled 'Aspects of the Biosynthesis of B-Lactam Antibiotics', with bibliography and figures for slides.

F.62-F.67: Visit to India, January 1985. The principal reason for Abraham's visit was to participate in the Asian Congress of Pharmacology, New Delhi, 14-19 January 1985. (He also visited 4 other cities, giving 5 seminars.) Includes correspondence regarding arrangements, a 21pp typescript draft of the lecture 'Penicillins and Cephalosporins and Antibiotics of the future' (given at the Asian Congress of Pharmacology), and a 23pp copy of the revised version.

Visits and conferences
Date: 1985-1986
Shelfmark: MS. Abraham 144/F.68-F.74
Language(s) of Material: English
Extent: 7 folders

Scope and Content

F.68-F.71: Hoechst Workshop Conference on 'Regulation of Secondary Metabolite Formation', Schloss Gracht, Germany, 12-16 May 1985. Abraham gave a lecture 'Enzymes Involved in Penicillin and Cephalosporin Formation'. Includes correspondence regarding arrangements and arising, a 3pp incomplete manuscript draft of Abraham's lecture with revisions' and a 14pp typescript of the lecture with additional pages of bibliographic references for possible publication.

F.72-F.74: 17th FEBS Meeting, West Berlin, 24-29 August 1986. Abraham gave a lecture entitled 'Beta lactamases' at one of the Meeting's symposia. Includes correspondence regarding arrangements and arising, a 1p manuscript draft outline of the lecture, an 18pp typescript of the lecture, with manuscript corrections, and additional typescript pages and figures.

Visits and conferences
Date: 1989-1995
Shelfmark: MS. Abraham 145/F.75-F.88
Language(s) of Material: English
Extent: 14 folders

Scope and Content

F.75-F.81: '50 Years of Penicillin Application', a Symposium in Honour of Abraham organized by the Technische Universität Berlin, West Berlin, 9-12 September 1990. Abraham gave a lecture entitled 'From Penicillins to Cephalosporins'. (The lecture was published in a book 50 Years of Penicillin Application - History and Trends, Technische Universität Berlin). Includes correspondence regarding arrangements and arising, 2pp manuscript and 1p typescript notes, 6pp and 2pp incomplete manuscript drafts with revisions, 10pp typescript version with manuscript corrections and 1p manuscript list of references, 11pp typescript final version (for publication), and correspondence regarding publication with expanded typescript version and corrected proofs.

F.82-F.83: Penicillin Symposium, University of Oxford, 28 September 1990. The event was held to mark the 50th anniversary of the publication of the paper on penicillin in the Lancet which described animal experiments. Abraham gave a lecture entitled 'Penicillin F and its B-lactam descendants: chance, motivation and personalities'. Includes correspondence regarding arrangements and arising, 1p of typescript notes for Abraham's lecture, and a 1p typescript entitled 'Extract from the Will of Sir William Dunn'.

F.84-F.85: Science and Medicine Conference, Royal College of Physicians, London, 6 and 7 November 1991. Abraham gave a lecture entitled 'Overview: past history of penicillins and cephalosporins'. Includes correspondence regarding arrangements and arising, an 18pp typescript draft of the lecture, with manuscript corrections and revisions, and drafts for accompanying slides.

F.86-F.87: 'Phenoxymethylpenicillin amidohydrolase from penicillium chrysogenum'. Inscriptions on the drafts in F.86 indicate that the lecture was intended for a FEBS meeting. Includes a 9pp draft with manuscript revisions, inscribed '1st Draft', a draft draft with manuscript corrections, inscribed '2nd Draft - reversibility - 6-APA?', and 3 further drafts, one entitled '4th Draft Oct 1995, with manuscript notes written to Abraham by another.

F.88: 1 page of a manuscript draft of an unidentified lecture, n.d.

G   Societies and organisations 1957-1998

Full range of shelfmarks:

MS. Abraham 146/G.1 - MS. Abraham 152/G.90


American Academy of Arts and Sciences
Date: 1983-1985
Shelfmark: MS. Abraham 146/G.1-G.5
Language(s) of Material: English
Extent: 5 folders

Scope and Content

Abraham was elected a foreign honorary member in 1983. In 1985 he gave an address to the Academy on 'Penicillin and its successors: a personal view'. Includes correspondence and papers regarding honorary membership and address, and manuscript notes and typescript drafts for address.

Australian National University
Date: 1981-1988
Shelfmark: MS. Abraham 147/G.6-G.20
Language(s) of Material: English
Extent: 15 folders

Scope and Content

In 1981 Abraham accepted an invitation to join a newly formed Advisory Board for the John Curtin School of Medical Research. He attended its first meeting in Canberra, 24 September 1982 but does not appear to have attended subsequent meetings. Abraham's correspondent is the Director of the John Curtin School, R. Porter. Includes correspondence, agenda, committee papers and minutes

Biochemical Society / British Association for the Advancement of Science / British Council
Date: 1960-1997
Shelfmark: MS. Abraham 148/G.21-G.32
Language(s) of Material: English
Extent: 12 folders

Scope and Content

G.21-G.26: Biochemical Society. Includes miscellaneous correspondence and papers, 19881-1997. Also includes correspondence and papers regarding Abraham's participation in the Society's programme of video recordings and related matters, 1989-1993. Abraham was recorded in conversation with Professor Robert Thomas at Imperial College London on 1 May 1990. The interview was arranged by the Society's Honorary Archivist, Professor H.F. Bradford (see MS. Abraham 190/J.41 for a videotape of the interview).

G.27-G.29: British Association for the Advancement of Science, 1980, 1986-1988. Includes correspondence and papers regarding Abraham's 53rd Royal Society BAYS [British Association Youth Section] Lecture, 1980. (Abraham delivered the lecture 'Penicillin and after' at Gravesend School for Boys, Kent, 23 October 1980.) Also includes correspondence and papers regarding the 1988 British Association for the Advancement of Science Annual Meeting at Oxford, 1986-1988.

G.30-G.32: British Council, 1960-1975. Includes correspondence and papers regarding Abraham's involvement in British Council activities, including a course on the use and abuse of antibiotics.

British Society for Antimicrobial Chemotherepy / Chemical Society / CIBA Foundation
Date: 1957-1996
Shelfmark: MS. Abraham 149/G.33-G.47
Language(s) of Material: English
Extent: 15 folders

Scope and Content

G.33-G.39: British Society for Antimicrobial Chemistry, 1972-1996. The Society was formed in August 1971 at the VIIth International Congress of Chemotherapy in Prague. Abraham was invited to join the Society in 1972 and became an honorary member in 1979. In 1974 he accepted an invitation to join the Editorial Board of the Society's new journal Antimicrobial Chemotherapy. Abraham delivered the 5th L.P. Garrod Lecture to the Society on 'B-Lactam Antibiotics: motivation, science and luck in their past and future', 21 November 1986. Correspondence and papers, including a typescript draft of Abraham's L.P. Garrod Lecture.

G.40-G.44: Chemical Society, 1965-1979. Correspondence and papers regarding publications, meetings, protein group etc., 1965-1979. Includes papers regarding the symposium 'Recent advances in the chemistry of B-lactam antibiotics', Cambridge, 28-30 June 1976.

G.45-G.47: The CIBA Foundation, 1957-1979. Correspondence and papers regarding symposium on amino-acids and peptides held in March 1958; correspondence and papers regarding a study group on resistance of bacteria to the penicillins, 1961-1962; and miscellaneous correspondence, 1973-1979.

Council for Science and Society
Date: 1985-1986
Shelfmark: MS. Abraham 150/G.48-G.57
Language(s) of Material: English
Extent: 10 folders

Scope and Content

The Council for Science and Society was founded in 1973 and published a number of reports on various social issues connected with science and technology. Abraham accepted an invitation in 1985 to join a study group on access to scientific information. Correspondence and papers regarding the work of the study group.

The Royal Society
Date: 1958-1998
Shelfmark: MS. Abraham 151/G.58-G.73
Language(s) of Material: English
Extent: 16 folders

Scope and Content

Abraham was elected to the Fellowship of the Royal Society in 1958, awarded the Royal Medal in 1973 and the Mullard Medal in 1980). General correspondence and papers, including correspondence, papers and photographs regarding an antibiotics exhibit for the Royal Society Tercentenary Exhibition, 1960, and papers regarding elections, 1959-1995.

Royal Society of Chemistry / Society for General Microbiology / Wellcome Trust
Date: 1957-1997
Shelfmark: MS. Abraham 152/G.74-G.90
Language(s) of Material: English
Extent: 17 folders

Scope and Content

G.74-G.78: Royal Society of Chemistry, 1985-1995. General correspondence and papers, 1985-1995. Correspondence and papers regarding the Centenary Tribute to Sir Robert Robinson at the 1986 Annual Congress 1985-1987. (Abraham talked on 'Sir Robert Robinson and the early history of penicillin'.) Correspondence and papers regarding the article 'The biosynthesis of penicillins and cephalosporins' written with J.E. Baldwin, 1985-1988.

G.79-G.81: Society for General Microbiology, 1963-1997. Abraham became a member in 1948 and resigned from the Society in 1997. Correspondence and papers regarding publications, meetings, and membership.

G.82-G.90: Wellcome Trust: Correspondence and papers regarding Abraham's applications to the Wellcome Trust for grants for equipment, travel and to modernise / extend the chemical pathology section of the Oxford Department of Pathology, 1957-1965. Correspondence with historians at the Wellcome Institute for the History of Medicine, London, 1985-1989.

H   Correspondence 1944-1998, n.d.

H.1   Scientific correspondence 1944-1998

Arrangement

Presented alphabetically by individual.


Full range of shelfmarks:

MS. Abraham 146/G.1 - MS. Abraham 152/G.90

Scientific correspondence: Baker - Betina
Date: 1964-1996
Shelfmark: MS. Abraham 153/H.1-H.20
Language(s) of Material: English
Extent: 20 folders

Scope and Content

H.1: Baker, W.L. Baker was based at the Swinburne College of Technology, Hawthorn, Melbourne, Australia. Correspondence regarding possibility of work on penicillin problems in Abraham's laboratory during sabbatical leave, 1976.

H.2-H.11: Baldwin, G.S. Baldwin came to Abraham's laboratory from the University of Melbourne in 1975 to work for two years as a postdoctoral researcher on the mechanism of enzyme function. He was subsequently based at the University of Adelaide and the Ludwig Institute for Cancer Research, Melbourne Tumour Biology Unit, Australia. Correspondence and papers regarding career, appointments, research and publications. Includes references and recommendations. 1974-1992.

H.12-H.19: Berks, M. (née McPhail). Berks worked in Abraham's laboratory, 1971-1977, first as a research assistant and then as a post-doctoral researcher. Correspondence regarding career, research, publications, and personal news. Includes references and recommendations. 1971-1996.

H.20: Betina, V. Betina was based at the Department of Microbiology and Biochemistry, Slovak Polytechnic University, Bratislava, Czechoslovakia. He met Abraham at the 'Antibiotica Congressus' in Prague, 1964 and subsequently worked in Abraham's Laboratory for a period in 1966 on the antibiotic activity of cyanein supported by a World Health Organization Senior Research Training Grant. Correspondence regarding arrangements for visit, publication, etc. 1964-1972.

Restrictions on Access:

Folders H.2-H.6, H.12-H.19 closed.


Scientific correspondence: Blackwell - Brightwell
Date: 1972-1977
Shelfmark: MS. Abraham 154/H.21-H.37
Language(s) of Material: English
Extent: 17 folders

Scope and Content

H.21: Blackwell, C.M. Blackwell was appointed to a two-year postdoctoral post in Abraham's laboratory in 1977. Correspondence concerns appointment only. Includes recommendations.

H.22-H.29: Bleaney, R.C. Bleaney was a postdoctoral organic chemist appointed to research in Abraham's laboratory on the synthesis of compounds related to penicillins and cephalosporins. Correspondence and papers regarding career, appointments, and research. Includes references and recommendations. 1974-1978

H.30: Brannan, S. Brannan was appointed to a two-year postdoctoral post in Abraham's laboratory, 1977. Correspondence concerns appointment only. Includes references and recommendations.

H.31-H.37: Brightwell, M. Brightwell came to Abraham's laboratory as a research assistant in 1972 to work on the structure and function of members of the penicillinase group of enzymes. Correspondence and papers regarding career, appointments, and research. Includes recommendations. 1972-1975.

Restrictions on Access:

Folders H.21-H.22, H.30-H.32 closed.


Scientific correspondence: Brötzu - Coombe
Date: 1971-1998
Shelfmark: MS. Abraham 155/H.38-H.54
Language(s) of Material: English
Extent: 17 folders

Scope and Content

H.38-H.42: Brötzu, G. Brötzu was Director of the Institute of Hygiene, University of Cagliari, Sardinia, Italy. He discovered the antibiotic properties of the cephalosporium organism in 1945 and provided it for further study to H.W. Florey and Abraham and their colleagues at Oxford University and the Medical Research Council in England which resulted in the development of the cephalosporin antibiotics. Correspondence and papers regarding the award of an honorary degree to Brötzu by Oxford University, 1971, and a reception and dinner given in Brötzu's honour by the National Development Research Council, 1972. Miscellaneous correspondence regarding Brötzu's death. 1971-1981.

H.43: Browne, C.A. Browne was a D.Phil. student in the Sir William Dunn School of Pathology. Recommendations. 1970-1976.

H.44: Brownlee, G.G. In 1980 Brownlee came from the MRC Molecular Biology Laboratory, Cambridge to take up the post of E.P. Abraham Professor of Chemical Pathology at the Sir William Dunn School of Pathology, Oxford. 1979-1980, 1987.

H.45-H.49: Chaudhury, R.R. Chaudhury was an Indian scientist who was a graduate student of Lincoln College, Oxford, 1955-1958. He pursued his career with the World Health Organisation (WHO) with a period at the Postgraduate Institute of Medical Education and Research, Chandigarh, India. Correspondence regarding career, visits, etc. 1971-1993, 1998.

H.50-H.52: Chmara, H. Chmara came from the Department of Pharmacology Technology and Biochemistry of the Technical University, Gdansk, Poland to work for a year, 1978-1979, in Abraham's laboratory on the antibiotic bacilysin. Correspondence and papers regarding arrangements for visit, research, publication, conference, etc. 1978-1984, 1989.

H.53-H.54: Coombe, R.G. Coombe came from the Pharmacy Department, University of Sydney to spend a sabbatical year from December 1971 in Abraham's laboratory. Correspondence and papers regarding arrangements for visit, research etc. Includes research reports. 1971-1977.

Restrictions on Access:

Folders H.43, H.52 closed.


Scientific correspondence: Cornelis - Crout
Date: 1958-1984
Shelfmark: MS. Abraham 156/H.55-H.73
Language(s) of Material: English
Extent: 19 folders

Scope and Content

H.55-H.66: Cornelis, G. Cornelis came from Université Catholique de Louvain, Belgium, to work in Abraham's Laboratory for a few months in 1974. Correspondence and papers regarding visit, research and publications. 1973-1978.

H.67: Crawford, K. Crawford was a Departmental Demonstrator in the Oxford Department, commencing 1 December 1954. Includes the report 'The enzymes inactivating Cephalosporins P and N and Penicillin'. 1958-1959.

H.68-H.73: Crout, D.H.G. Crout was based at the Department of Chemistry, Exeter University. Correspondence and papers regarding research and publications. 1979-1984.

Scientific correspondence: Davies - Fawcett
Date: 1953-1997
Shelfmark: MS. Abraham 157/H.74-H.91
Language(s) of Material: English
Extent: 18 folders

Scope and Content

H.74-H.78: Davies, R.B. Davies was a D.Phil. student of Abraham's from October 1970. Correspondence and papers regarding career, research, and publications. 1969-1974.

H.79: Dougall, D.K. Principally research reports. 1953-1956.

H.80: Duncan, M.J. Duncan was a D.Phil. student in the Sir William Dunn School of Pathology. Includes references and recommendations. 1965-1971.

H.81: Dyke, K.D.G. Correspondence and papers regarding research and career. Includes references and recommendations. 1966-1967.

H.82-H.84: Edwards, G.F. St L. Edwards worked in Abraham's laboratory as a post-doctoral research assistant, 1974-1977. Correspondence and papers regarding career and publication, with research notes and reports. Includes references and recommendations. 1974-1979.

H.85-H.91: Fawcett, P.A. Fawcett came to Oxford to work as a research assistant in Abraham's laboratory, taking a D.Phil. under his supervision. After a period in the USA she returned to England in 1979 and resumed research in Abraham's laboratory in 1983. Correspondence and papers from 1975 are under her married name of Whiteman. Correspondence regarding career, research, publications, etc. Includes references and recommendations. 1971-1997.

Restrictions on Access:

Folders H.74, H.80-H.82, H.85 closed.


Scientific correspondence: Fisher - Furth
Date: 1970-1980
Shelfmark: MS. Abraham 158/H.92-H.107
Language(s) of Material: English
Extent: 16 folders

Scope and Content

H.92-H.97: Fisher, A.J. Fisher undertook D.Phil research under Abraham's supervision. Correspondence and papers regarding D.Phil. supervision, 1976-1980. Also includes an 84pp typescript draft on B-lactam antibiotics with extensive manuscript revision. 1976-1980.

H.98: Freeman, R.F. Correspondence and papers regarding application to undertake D.Phil research in Abraham's laboratory. Includes references and recommendations. 1972-1973.

H.99: Fukumura, T. Fukumura came from Osaka City University, Japan to research on B-lactamase in Abraham's laboratory for a period in 1976. Correspondence regarding arrangements, etc. 1975-1979.

H.100: Fuller, K.W. Fuller was based at the Botany School, Oxford University. Includes a paper on a proposed course on industrial biology. 1970.

H.101-H.107: Furth, A.J. Furth was a post-doctoral researcher in Abraham's laboratory from January 1971 working on the active site of B-lactamase enzymes. She subsequently took up a post with the Open University. Correspondence and papers regarding career, appointments, research, and publications. 1971-1977.

Restrictions on Access:

Folders H.98, H.101 closed.


Scientific correspondence: Ghuysen - Harris
Date: 1962-1992
Shelfmark: MS. Abraham 159/H.108-H.118
Language(s) of Material: English
Extent: 11 folders

Scope and Content

H.108: Ghuysen, J.-M. Ghuysen was based at the University of Liège, Belgium. Correspondence regarding research. 1976-1977.

H.109-H.110: Glynn, M.F. Abraham took over Glynn's D.Phil. supervision on the sudden death of his previous supervisor. Principally regarding Glynn's Oxford D.Phil. thesis. 1970-1973.

H.111: Gore, P.J.M. Gore worked as a research assistant in Abraham's laboratory for a period from 1 February 1977. Correspondence regarding career and research. 1975-1978.

H.112-H.115: Gunetileke, K.G. Gunetileke was a Sinhalese who came from the Department of Biochemistry, University of Toronto to spend a year in Abraham's laboratory, 1968-1969, as a postdoctoral fellow before returning to Ceylon. Correspondence regarding arrangements to work in Abraham's laboratory, subsequent career etc., 1967-1978. Includes references and recommendations. Also includes research notes, September 1968-July 1969.

H.116-H.118: Harris, H. Harris was head of the Sir William Dunn School of Pathology, 1963-1994 and Regius Professor of Medicine, University of Oxford, 1979-1992. Includes correspondence regarding Harris's move to Oxford in 1963, the typescripts 'Thoughts on the Regius Professorship of Medicine' and 'Why scientists do animal experiments', and a curriculum vitae and bibliography. 1962-1992.

Restrictions on Access:

Folders H.111-H.113 closed.


Scientific correspondence: Heatley - Jayatilake
Date: 1948-1993
Shelfmark: MS. Abraham 160/H.119-H.131
Language(s) of Material: English
Extent: 13 folders

Scope and Content

H.119-H.121: Heatley, N.G. Heatley was a member of the team of scientists under H.W. Florey who produced in Oxford and tested and investigated penicillin. He also contributed to some of the early work on cephalosporium cultures. Includes 'The antibiotic from tulip', a typescript and manuscript draft with manuscript comments by Abraham, and papers regarding the history of penicillin. 1948, 1962, 1983-1991.

H.122: Hopwood, D.A. Hopwood was the head of the Department of Genetics, John Innes Institute, Norwich. Correspondence regarding research. 1982.

H.123-H.125A: Huddleston, J.A. (née Mitchell). Huddleston worked as a research assistant in Abraham's laboratory from October 1974. Correspondence regarding appointment, research notes, and drafts. 1974-1980.

H.126-H.131: Jayatilake, G. S. Jayatilake was a Sri Lankan organic chemist who came to Abraham's laboratory in 1978 where he worked on the biosynthesis of penicillins and cephalosporins in cell-free systems. Correspondence and papers regarding career and appointments, research reports, and printed material. Principally references and recommendations. 1978-1993.

Restrictions on Access:

Folders H.126-H.128 closed.


Scientific correspondence: Jeffery - Kasik
Date: 1959-1986
Shelfmark: MS. Abraham 161/H.132-H.139
Language(s) of Material: English
Extent: 8 folders

Scope and Content

H.132-H.134: Jeffery, J. Jeffery was a graduate student in the Sir William Dunn School of Pathology, 1958-1961, working on the chemistry and biochemistry of a member of the cephalosporin family. Correspondence and papers regarding career and appointments. Principally references and recommendations. 1959, 1970-1981.

H.135-H.139: Kasik, J.E. In 1966 Kasik spent sabbatical leave from the Department of Medicine, University of Chicago researching in Abraham's laboratory where he worked on the relationship between penicillinase production and the sensitivity of mycobacteria to penicillins and cephalosporins. Correspondence regarding research, publications, etc. 1965-1986.

Restrictions on Access:

Folders H.132-H.134 closed.


Scientific correspondence: Kenig - Kiener
Date: 1970-1990
Shelfmark: MS. Abraham 162/H.140-H.153
Language(s) of Material: English
Extent: 14 folders

Scope and Content

H.140-H.148: Kenig, M.D.J. Kenig came from the Beecham Research Laboratories, Brockham Park, Surrey, to undertake D.Phil. research on the peptide antibiotic bacilysin under Abraham's supervision. Correspondence regarding career, appointments, research, and publications. Includes references and recommendations. 1970-1976.

H.149: Khuon, E. von. Correspondence regarding proposed television documentary about Sir Alexander Fleming. 1984.

H.150-H.153: Kiener, P.A. Kiener was a D. Phil. student (supervisor S.G. Waley) in the Sir William Dunn School of Pathology where he later did postdoctoral work. Correspondence and papers regarding career and appointments. Chiefly references and recommendations. 1973-1990.

Restrictions on Access:

Folders H.140-H.141, H.150-H.153 closed.


Scientific correspondence: Kuwabara - Luego
Date: 1956-1993
Shelfmark: MS. Abraham 163/H.154-H.169
Language(s) of Material: English
Extent: 16 folders

Scope and Content

H.154-H.160: Kuwabara, S. Kuwabara came to Abraham's laboratory as a postdoctoral member of his research staff paid for by the Medical Research Council from 1 January 1966. Correspondence regarding career, appointments, research, publications, etc. Includes references and recommendations. 1964-1993.

H.161-H.165: Loder, P.B. Loder was graduate assistant to G.G.F. Newton in the Sir William Dunn School of Pathology, 1957-1959 and research assistant to Abraham, 1965-1966 and 1968-1972 working on cephalosporin and penicillin antibiotics. Correspondence regarding career, appointments, research, publications, etc. Includes references and recommendations. 1956-1975, 1986.

H.166-H.169: Luego, J.M. Luego came from the University of Salamanca, Spain to work in Abraham's laboratory as a postdoctoral fellow. Correspondence re arrangements to work in Abraham's laboratory including fellowship application, papers regarding publications, and a research report. 1979-1985.

Restrictions on Access:

Folders H.154-H.155, H.161-H.163 closed.


Scientific correspondence: Marston - Miller
Date: 1961-1981
Shelfmark: MS. Abraham 164/H.170-H.181
Language(s) of Material: English
Extent: 12 folders

Scope and Content

H.170: Marston, R.Q. Marston was Director of the National Institutes of Health, Bethesda, Maryland, 1968-1973. Includes curriculum vitae and lists of addresses and publications. 1973

H.171-H.174: Migliacci, A. Migliacci came from Farmitalia, Milan, Italy to work for a period in Abraham's laboratory. Correspondence and papers re research, 1961-1963, 1969, most undated.

H.175-H.181: Miller, J.M.T. Hamilton-. Correspondence and papers regarding move to Oxford, research, publications etc. Includes references and recommendations. 1965-1981.

Restrictions on Access:

Folders H.180-H.181 closed.


Scientific correspondence: Newton, G.G.F.
Date: 1944-1997
Shelfmark: MS. Abraham 165/H.182-H.196
Language(s) of Material: English
Extent: 15 folders

Scope and Content

Newton became a D.Phil. student in the Sir William Dunn School of Pathology in 1947 with Abraham as his supervisor. They continued to work together until his death in 1969. Much of the early work was concerned with antibiotic peptides such as bacitracin. Later Newton made substantial contributions to the isolation of Penicillin N and Cephalosporin C and the determination of their structures. Correspondence includes:

H.182-H.189: Correspondence and papers regarding career, research, publications, visits, etc. with Abraham and others, 1948-1968.

H.191-H.194: Correspondence and papers arising from Newton's death including obituaries, January-September 1969.

Scientific correspondence: O'Sullivan - Pang
Date: 1975-1996
Shelfmark: MS. Abraham 166/H.197-H.211
Language(s) of Material: English
Extent: 15 folders

Scope and Content

H.197-H.201: O'Sullivan, J. Sullivan came from the Eidgenössiche Technische Hochschule, Zürich, to work in a postdoctoral position in Abraham's laboratory, 1975-1979, on the biosynthesis of penicillins and cephalosporins. Correspondence and papers regarding career, appointments, research, and publications. Includes references and recommendations. 1975-1994.

H.202-H.211: Pang C.-P. Pang was a D.Phil. student at Oxford under Abraham's supervision, 1978-1981. He was a postdoctoral research assistant in Abraham's laboratory, 1982-1983. Correspondence and papers regarding career, appointments, research, publications, visits etc. 1975-1996.

Restrictions on Access:

Folders H.197-H.199, H.202-H.203 closed.


Scientific correspondence: Park - Robinson
Date: 1970-1990
Shelfmark: MS. Abraham 167/H.212-H.231
Language(s) of Material: English
Extent: 20 folders

Scope and Content

H.212: Park, J.T. Park was based at the Department of Microbiology, University of Umea, Sweden. Correspondence regarding a visit to Oxford, 1970.

H.213-H.226: Perry, D. Perry came from the University of Birmingham to work in a postdoctoral position in Abraham's laboratory. Correspondence and papers regarding career, appointments, research, and publications. Includes references and recommendations. 1974-1989.

H.227: Richmond, M.H. Richmond was Professor of Bacteriology, University of Bristol. Correspondence regarding research etc. 1970-1978.

H.228-H.231: Robinson, R. Correspondence regarding historical reflections, Robinson's scientific memoirs, biography of Robinson, etc. 1971-1990.

Restrictions on Access:

Folders H.213-H.215 closed.


Scientific correspondence: Sabath - Stevens
Date: 1962-1993
Shelfmark: MS. Abraham 168/H.232-H.253
Language(s) of Material: English
Extent: 22 folders

Scope and Content

H.232-H.246: Sabath, L.D. Sabath came from the Harvard Medical School, Boston, Massachusetts, to work in Abraham's laboratory, 1963-1964. Correspondence regarding arrangements to come to Oxford, research, publications, visits, career, and appointments. 1962-1993.

H.247-H.248: Schaaf, C.H. Schaaf was Resident Representative of the United Nations Development Programme in Ceylon when the correspondence was initiated. Principally non-scientific correspondence but includes a few references to Abraham's work. 1971-1993.

H.249-H.253: Stevens, C.M. Stevens came from the Chemistry Department, Washington State University, to spend a sabbatical year in Abraham's laboratory, 1973-1974. Correspondence and papers re arrangements for sabbatical, research, publications etc. 1972-1980.

Scientific correspondence: Thorniley - Umezawa
Date: 1972-1986
Shelfmark: MS. Abraham 169/H.254-H.268
Language(s) of Material: English
Extent: 15 folders

Scope and Content

H.254-H.255: Thorniley, M.S. Thorniley was appointed as a research assistant in the Sir William Dunn School of Pathology in 1984. Correspondence regarding appointment, research notes, and drafts. 1984-1986.

H.256-H.266: Umezawa, H. Umezawa was Director of the Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Tokyo, Japan. He visited Oxford on a number of occasions, receiving an honorary degree from the University in 1981. Correspondence regarding visits to Oxford, honorary degree etc. Also includes obituary and miscellaneous biographical information. 1972-1986.

H.267-H.268: Umezawa, K. Kazuo Umezawa was the son of H. Umezawa. In 1973 he came to Oxford to read medicine. Correspondence and papers regarding move to Oxford in 1973 and subsequent visits. 1972-1986.

Restrictions on Access:

Folders H.267-H.268 closed.


Scientific correspondence: Usher, J.J.
Date: 1970-1991
Shelfmark: MS. Abraham 170/H.269-H.281
Language(s) of Material: English
Extent: 13 folders

Scope and Content

Correspondence and papers regarding career, appointments, publications, research notes, and drafts.

Scientific correspondence: Vandamme - Vlietinck
Date: 1973-1994
Shelfmark: MS. Abraham 171/H.282-H.289
Language(s) of Material: English
Extent: 8 folders

Scope and Content

H.282-H.286: Vandamme, E.J.M.C. Vandamme came from the University of Ghent, Belgium to work in Abraham's laboratory during the summer of 1973. Correspondence regarding arrangements for stay in Oxford, research, publications, D.Sc. thesis, etc. 1973-1994.

H.287-H.288: Vanderhaeghe, H. Vanderhaeghe was based at the Rega Instituut, Katholieke Universiteit Leuven, Belgium and researched in the penicillin field. Abraham gave a lecture on 'B-Lactam Antiobiotics: Science and Serendipity' on the occasion of Vanderhaeghe's retirement in 1987. Correspondence regarding research, visits, etc. and correspondence regarding Abraham's visit on the occasion of Vanderhaeghe's retirement and a draft of his lecture. 1973-1987.

H.289: Vlietinck, A.J. Vlietninck was based at the Pharmacy Department, Antwerp University. Correspondence re proposed research project on Levamisole, 'a new drug with immunoregulatory properties'.

Scientific correspondence: Waley - White
Date: 1969-1997
Shelfmark: MS. Abraham 172/E.290-E.305
Language(s) of Material: English
Extent: 16 folders

Scope and Content

H.290-H.297: Waley, S.G. Waley was University Lecturer in Pathology, Sir William Dunn School of Pathology, Oxford, 1970-1989. Correspondence and papers regarding the move to the Sir William Dunn School of Pathology, research notes and drafts, and an obituary by Abraham, Independent, 1 January 1994. 1969-1994.

H.298-H.301: Walker, J.E. Walker undertook D.Phil. research under Abraham's supervision, 1966-1969. He was awarded the 1997 Nobel Prize for Chemistry. Correspondence regarding research and publications. Includes photographs. 1969-1976, 1988, 1995, 1997.

H.302: Warren, S.G. Warren was based at the Sir William Dunn School of Pathology, 1962-1966. Correspondence regarding research and career. Includes recommendation. 1966-1967, 1980.

H.303-H.305: White, R.L. White came from McMaster University, Ontario, Canada in November 1979 to work as a Postdoctoral Fellow in Abraham's group. Correspondence regarding research, publications, career, and appointments. Includes references and recommendations.

Restrictions on Access:

Folders H.302-H.305 closed.


Scientific correspondence: Wylie, J.A.H.
Date: 1968-1987
Shelfmark: MSS. Abraham 173-174/H.306-H.334
Language(s) of Material: English
Extent: 29 folders

Scope and Content

Wylie was a microbiologist and experimental pathologist. Correspondence and papers, including curriculum vitae, obituary, and copies of Wylie's publications on the history of medicine and the history of religion.

H.2   Scientific correspondence 1946-1995

Arrangement

Presented alphabetically by country.


Full range of shelfmarks:

MS. Abraham 175/H.335 - MS.Abraham 183/H.495

Australia / Belgium
Date: 1959-1995
Shelfmark: MS. Abraham 175/H.335-H.349
Language(s) of Material: English
Extent: 15 folders

Scope and Content

Australia, 1959-1995:

H.335-H.340: IUPAC International Symposium on the Chemistry of Natural Products, Melbourne, Canberra and Sydney, Australia, 15-25 August 1960. Correspondence regarding arrangements for Abraham to give a paper at the symposium, Abraham's addresses, a reprint of his symposium paper, and correspondence arising from his visit.

H.341-H.342: Miscellaneous correspondence with Australian scientists, 1961-1995.

Belgium, 1969-1993:

H.343-H.346: European Meeting on Medicinal Chemistry, Brussels, 14-17 September 1970. Abraham gave a plenary lecture on 'Some contributions of synthesis and semisynthesis to antibacterial and antiviral chemotherapy'. Correspondence regarding arrangements for meeting, publication of plenary lecture etc.; typescript draft of Abraham's plenary lecture; programme and list of participants.

H.347: Miscellaneous correspondence with Belgian scientists, 1972-1993.

H.348-H.349: Correspondence and papers regarding the George Sarton Chair, University of Ghent, 1988-1991. Abraham was chosen for the George Sarton Chair for the academic year, 1989-1990.

Canada /China / Czechoslovakia / Denmark /Germany
Date: 1955-1994
Shelfmark: MS. Abraham 176/H.350-H.365
Language(s) of Material: English
Extent: 16 folders

Scope and Content

Canada, 1955-1985:

H.350: Miscellaneous correspondence with Canadian scientists, 1955-1963.

H.351-H.353: Correspondence and papers regarding Symposium on Antibiotics, Ste Marguerite, Quebec, 1-3 March 1971.

H.353: Miscellaneous correspondence with Canadian scientists, 1972-1985.

China, 1982-1987:

H.354: Correspondence regarding review article by Abraham for the Chinese Journal of Antibiotics, with draft of article, 1982-1984.

H.355: Correspondence regarding visit to Abraham's department by a Chinese scientist, 1986-1987.

Czechoslovakia, 1960-1986:

H.356-H.358: Correspondence and papers regarding Antibiotics Congress held in Prague, June 1964.

H.359-H.360: Miscellaneous correspondence with Czechoslovak scientists, 1961-1974, 1986.

Denmark, 1971-1991:

H.361-H.362: Correspondence and papers regarding Euchem Conference on Antibiotics Biosynthesis and Function held in Aarhus 28 August-2 September 1972.

H.363: Miscellaneous correspondence with Danish scientists, 1982-1991.

Germany, 1970-1994:

H.364-H.365: Miscellaneous correspondence with German scientists.

Italy / India and Pakistan
Date: 1961-1991
Shelfmark: MS. Abraham 177/H.366-H.381
Language(s) of Material: English
Extent: 16 folders

Scope and Content

Italy, 1961-1991:

H.366: Correspondence regarding arrangements etc. for A. Migliacci of Farmitalia to work for a period of six months in Abraham's laboratory, 1961-1962.

H.367: Miscellaneous correspondence with Italian scientists, 1962-1965.

H.368: Correspondence and papers regarding 6th International Congress of the International Society of Clinical Pathology held in Rome, October 1966.

H.369: Miscellaneous correspondence with Italian scientists and others, 1968-1971.

H.370: Miscellaneous correspondence with Italian scientists, 1973-1976.

H.371: Correspondence and papers re scientific meetings held in Italy, 1978. Includes a draft of Abraham's introductory remarks for a round table on cerufoxime at 3rd International Symposium on 'Future Trends in Chemotherapy' held in Pisa, May 1978.

H.372-H.373: Correspondence and papers regarding symposium on 'Action of Antibiotics in Patients' held in Florence 18 July 1981

H.374-H.375: Correspondence and papers regarding symposium 'From Genetic Experimentation of Biotechnology the Critical Transition' held in Rome, 20-23 September 1981

H.376-H.377: Correspondence and papers regarding international meeting on 'Trends in Microbial Resistance to B-Lactam Antibiotics Molecular Aspects and Clinical Implications' held in L'Aquila and Rome, 12-15 May 1990.

India and Pakistan, 1961-1987:

H.378-381: Correspondence and papers regarding research, publications and visits.

Japan
Date: 1953-1977
Shelfmark: MS. Abraham 178/H.382-H.401
Language(s) of Material: English
Extent: 20 folders

Scope and Content

H.382: Correspondence with Japanese scientists, 1953-1954, 1961-1962.

H.383-H.388: Correspondence and papers regarding the IUPAC Symposium on 'The Chemistry of Natural Products' Kyoto, 12-18 April 1964

H.389: Correspondence with Japanese scientists, 1965-1966.

H.390: Correspondence with Japanese scientists, 1967. Includes papers regarding the Journal of Antibiotics.

H.391: Correspondence with Japanese scientists, 1968-1969.

H.392-H.394: Correspondence with Japanese scientists and others, 1970-1973.

H.395-H.400: Correspondence and papers regarding visit to Japan and the USA, 1974. Abraham attended the First Intersectional Congress of the International Association of Microbiological Societies in Tokyo in early September and then flew to San Francisco for the Fourteenth Interscience Conference on Antimicrobial Agents and Chemotherapy.

H.401: Correspondence with Japanese scientists, 1974-1977.

Japan
Date: 1977-1992
Shelfmark: MS. Abraham 179/H.402-H.421
Language(s) of Material: English
Extent: 20 folders

Scope and Content

H.402-H.408: Correspondence and papers regarding visit to Japan in 1977.

H.409-H.420: Correspondence with Japanese scientists, 1978-1990.

H.421: Correspondence with S. Yamabe, System Director of Drug Research System International, 1991-1992.

Malaysia / Spain / Sweden
Date: 1970-1994
Shelfmark: MS. Abraham 180/H.422-H.438
Language(s) of Material: English
Extent: 17 folders

Scope and Content

Malaysia, 1976-1994:

H.422: Correspondence with Malaysian scientists, 1976-1977.

H.423: Correspondence with Ho Coy Choke of the Department of Genetics and Cellular Biology, University of Malaya, and others, 1980-1981.

H.424-426: Correspondence and papers regarding the First Asian Workshop on Fermentation Technology held in Kuala Lumpur, 22-24 February 1982.

H.427-H.428: Correspondence with Malaysian and Singaporean scientists, 1982-1988.

H.429: Correspondence with Ho Coy Choke, Department of Genetics and Cellular Biology, University of Malaya, 1989-1994.

Spain, 1970-1993:

H.430: Correspondence regarding an article on the chemistry of new antibiotics for Tribuna Medica, 1970-1971.

H.431: Correspondence and papers regarding the Third International Symposium on Yeast Protoplasts in Salamanca, 2-5 October 1972

H.432: Correspondence with Spanish scientists regarding research and visits, 1978-1981, 1986, 1993.

Sweden, 1975-1992:

H.433-H.437: Correspondence and papers regarding visit to Sweden in December 1975.

H.438: Correspondence with Swedish scientists and others, 1976, 1984-1992.

USA
Date: 1946-1963
Shelfmark: MS. Abraham 181/H.439-H.453
Language(s) of Material: English
Extent: 15 folders

Scope and Content

General correspondence with American scientists and others.

USA
Date: 1964-1991
Shelfmark: MS. Abraham 182/H.454-H.476
Language(s) of Material: English
Extent: 23 files

Scope and Content

H.454-H.460: General correspondence with American scientists and others, 1964-1972.

H.461: Correspondence and papers regarding a visit to the USA by Abraham in May, 1973.

H.462-H.464: General correspondence with American scientists and others, 1975-1991.

H.465-H.469: Correspondence with colleagues at Harvard regarding visits, conferences, lectures, publications etc., 1978-1993.

H.470-H.471: Correspondence with colleagues at Lederle Laboratories, Pearl River, New York, 1959-1963.

H.472-H.476:Correspondence with colleagues at the Massachusetts Institute of Technology regarding research, visits, publications etc., 1973-1991.

USA / USSR
Date: 1957-1988
Shelfmark: MS.Abraham 183/H.477-H.495
Language(s) of Material: English
Extent: 19 folders

Scope and Content

USA:

H.477-H.480: Correspondence with colleagues at Rutgers University, New Brunswick, New Jersey, and others, 1957-1981.

H.481-H.482: Correspondence with colleagues at Berkeley, principally Melvin Calvin and others at the Laboratory of Chemical Biodynamics, 1977-1988.

H.483-H.493: Correspondence with colleagues at University of Wisconsin-Madison regarding research collaboration in the field of penicillin and cephalosporin biosynthesis, visits etc. Abraham's principal correspondent is C.J. Sih of the School of Pharmacy. 1973-1986.

USSR:

H.494-H.495: Correspondence with colleagues regarding research, visits, etc., 1960-1984.

H.3   Shorter scientific correspondence 1944-1998, n.d.

Arrangement

Chronological sequence.


Full range of shelfmarks:

MS. Abraham 184/H.496 - 186/H.534

Shorter scientific correspondence
Date: 1944-1965
Shelfmark: MS. Abraham 184/H.496-H.510
Language(s) of Material: English
Extent: 15 folders

Scope and Content

Shorter correspondence regarding research, visits, publications, equipment and supplies, etc.

Shorter scientific correspondence
Date: 1966-1979
Shelfmark: MS. Abraham 185/H.511-H.524
Language(s) of Material: English
Extent: 14 folders

Scope and Content

Shorter correspondence regarding research, visits, publications, equipment and supplies, etc.

Shorter scientific correspondence
Date: 1980-1998, n.d.
Shelfmark: MS. Abraham 186/H.525-H.534
Language(s) of Material: English

Scope and Content

Shorter correspondence regarding research, visits, publications, equipment and supplies, etc.

H.4   References and recommendations 1958-1996

Full range of shelfmarks:

MS. Abraham 187/H.535 - MS. Abraham 188/H.563

References and recommendations
Date: 1958-1996
Shelfmark: MS. Abraham 187/H.535-H.549
Language(s) of Material: English
Extent: 10 folders

Scope and Content

Miscellaneous correspondence and papers regarding appointments, promotions, grant applications, etc.

Restrictions on Access:

Closed.


External examining and refereeing
Date: 1961-1994
Shelfmark: MS. Abraham 188/H.550-H.563
Language(s) of Material: English
Extent: 14 folders

Scope and Content

Correspondence and papers regarding external examining.

Indian higher education and research institutions:

H.550-H.551: Andhra University, 1962-1964.

H.552: Banaras Hindu University, 1962-1963.

H.553-H.558: Indian Institute of Science, Bangalore, 1961-1976.

H.559: University of Calcutta, 1965.

Malaysia:

H.560-H.563: Correspondence regarding external examining and refereeing for the University of Malaya, 1977-1994.

Restrictions on Access:

Closed.


I   Non-text material 1930-1995, n.d.

I.1   Photographs 1930-1995, n.d.

Full range of shelfmarks:

MS. Abraham 189/J.1 - MS. Abraham 189/J.31

Photographs
Date: 1930-1995, n.d.
Shelfmark: MS. Abraham 189/J.1-J.31
Language(s) of Material: English
Extent: 31 folders

Scope and Content

Abraham and family:

J.1-J.2: 2 photographs (mounted) of school hockey teams, including Abraham, 1930.

J.3: Photograph (mounted) of school rugby team, including Abraham, inscribed 'School 2nd XV 1930'.

J.4: Abraham in group photograph (mounted), possibly from his undergraduate years, 1932-1936.

J.5: Abraham seated on a terrace, possibly on a visit to Norway, n.d.

J.6: Abraham and [?his wife] on a picnic, n.d.

J.7: 2 photographs of Abraham standing in a room, location unknown, n.d.

J.8: Portrait of Abraham, n.d.

J.9: Abraham and his wife, inscribed on verso 'Dr and Mrs Abraham, June 1975'.

J.10: Abraham at home, inscribed '19 February 1978, by S. Kuwabara.'

J.11: Abraham, with mountain scenery in background, possibly taken in Norway, 1979.

J.12: Portrait of Abraham in later years seated at a desk, n.d.

J.13: Portrait of Abraham in later years.

J.14: Abraham standing on a roof top, possibly of his home, n.d.

J.15: Abraham reading in a chair in later years.

Visits, events and colleagues:

J.16: Photographs, one each of Abraham [c.1938-1950]; Ernst Chain, n.d.; and Howard Florey, n.d.

J.17: Group photograph of Abraham and other Royal Society medallists, 1980, inscribed 'Sir Denys Wilkinson, Professor W.F. Vinen, Dr. J.P. Wild, Sir Edward Abraham, Dr. F.J.M Farley, Dr. C. Milstein, Professor A.W Johnson, Sir Derek Barton, Professor Henry Harris, Professor Wright'. (Abraham received the Mullard Prize in 1980.)

J.18: Photograph of a portrait of Robert Robinson with inscription: 'Pleased to have your photo in the D.P album. Original at R. Soc. rooms', 4 November 1955.

J.19: Photograph of Guy Newton, n.d.

J.20: Abraham and Edwin H. Flynn in front of an exhibition display. Labelled on verso: 'Professor E.P Abraham, who was involved in the early development work on the cephalosporins in Oxford, recently visited Eli Lilly in Indianapolis. He is shown with Dr. Edwin H. Flynn, one of the Lilly scientists who contributed to the development of this new antibiotic "family"', n.d.

J.21: Abraham and Edwin H. Flynn in front of an exhibition display. Labelled on verso as in J.20.

J.22: Photograph of Abraham's wife with various people, including Henry Harris, n.d.

J.23: Abraham, in later years, seated in an audience at a ?conference, n.d.

J.24: Photograph of Abraham with Indian scientists, taken during his visit to India in January 1985. The names of the Indian scientists, as inscribed on verso, are R.K. Nand, P.V. Deshmukb, Rama Rao (from National Chemical Laboratory), P.S Borkar, N.R. Chatterjee.

J.25: Group photograph of Abraham and colleagues inscribed 'Sir Edward Abraham's visit to the Hope Library [Oxford] on Tuesday, October 10th 1989'. Also featured are. F.B. Atkins, Curator of Mineralogical Collections; T. S Kemp, Curator of Zoological Collections; D. Spencer Smith; J.D.C. McConnell, Dept. of Earth Sciences; W.J. Kennedy, Curator of Geological Collections; S.J. Simpson, Principal Curator; G.A. Harrison, Chairman of the Committee for Scientific Collections.

J.26: Abraham and other Honorary graduands, including Jack Baldwin at the award of Honorary Doctor of Science Degree ceremony at Strathclyde University, 13 July 1989.

J.27: Abraham with the Chancellor of Strathclyde University.

J.28: Various photographs taken at the '50 Years of Penicillin Application' symposium, organized by the Technische Universitat Berlin, West Berlin, 9-12 September 1980.

J.29: Photograph of Abraham, inscribed 'Int. Congress T.M.R.A-L'Aquila and Rome May 12-15 1990.'

J.30: Various photographs, contents of an envelope inscribed 'Portrait by Daphne Tod, Sent 1991'.

J.31: Photograph inscribed 'John Walker, Admission to R. S. 1995'.

I.2   Slides and videos 1978-1990, n.d.

Full range of shelfmarks:

MSS. Abraham 190-191

Slides and videos
Date: 1978-1990, n.d.
Shelfmark: MS. Abraham 190/J.32, J.34-J.41
Language(s) of Material: English
Extent: 9 items

Scope and Content

J.32: 1 box of 3 lantern slides contained in a box labelled 'Pen. Chem.' Slides used for a lecture.

J.34: 1 box of 13 slides labelled 'Ceph. Mycelin Electron Micrographs'.

J.35: 1 box labelled 'Prof. Abraham' containing 18 slides. Some slides are dated 1978.

J.36: 1 box labelled 'Sulphanilamide other antibiotics-bioconversion' containing 11 slides.

J.37: 1 box of 14 slides labelled 'Pseudomonas B-lactam' and 'Mary Pseudomonas Enzyme'.

J.38: 1 box labelled' Set 1 Baldwin' and 'B-lactamases' containing 16 slides.

J.39: Videotape of the Honorary Doctor of Science Degree ceremony at Strathclyde University, 13 July 1989. Abraham was one of the graduands.

J.40: Videotape of a series of lectures organised to celebrate the 50th anniversary of the publication of a paper on the production and therapeutic application of penicillin. The venue was the Sir William Dunn School of Pathology.

J.41: Videotape ''Conversation with Eminent Biochemists'. Abraham in conversation with R. Thomas, Imperial College London, 1 May 1990.

Slides and videos
Date: n.d.
Shelfmark: MS. Abraham 191
Language(s) of Material: English
Extent: 1 box

Scope and Content

Includes:

J.33: 1 box of 41 lantern slides used to illustrate a lecture or lectures on penicillin.

J.42: Videotape: 'The Action of antibodies on Bacteria'.

J.43: Videotape: 'Cephalosporins in Perspective'.


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05 March 2018